This menu provides the list of EV proteins identified by high-throughput analyses.
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Dataset accession
UniProt accession
UniProt name
Protein name
Gene symbol
Species
Orthologous group
Superdomain:
All
Prokaryote
Eukaryote
Filter datasets:
- "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
- "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
By species
Homo sapiens
In vitro/In vivo
Ex vivo
In vitro
In vivo
By sample type
Amnion epithelial cell
Aortic vascular smooth muscle cell
Ascites
B cell
B cell (MM.1R)
B cell (MM.1S)
B cell (RN (HLA-DR15))
B cell (RPMI 8226)
B cell (U266)
Bladder cancer cell (HT1376)
Bladder cancer cell (UMUC-3, J82, SW780)
Blood
Bone marrow aspirate
Bone marrow-derived mesenchymal stem cell (MSC)
Brain
Breast cancer cell (BT549)
Breast cancer cell (HS 578T)
Breast cancer cell (MCF-7)
Breast cancer cell (MCF7)
Breast cancer cell (MDA-MB-231)
Breast cancer cell (MDA-MB-468)
Breast cancer cell (MDA-MB231)
Breast cancer cell (T-47D)
Bronchial epithelial cell (30KT)
Bronchial epithelial cell (BEAS2B)
Carotid atherosclerotic plaque
Central nervous system cancer cell (SF268)
Central nervous system cancer cell (SF295)
Central nervous system cancer cell (SF539)
Central nervous system cancer cell (SNB-19)
Central nervous system cancer cell (SNB-75)
Central nervous system cancer cell (U251)
Cerebral microvascular endothelial cell (hCMEC/D3)
Cerebrospinal fluid
Cervical cancer (HeLa)
Chronic B-cell
Chronic lymphoid leukemia cell (JVM-3)
Chronic lymphoid leukemia cell (MEC-1)
Colon cacinoma cell (SW480)
Colon cancer cell (Colo205)
Colon cancer cell (HCC 2998)
Colon cancer cell (HCT-116)
Colon cancer cell (HCT-15)
Colon cancer cell (HT29)
Colon cancer cell (KM12)
Colon cancer cell (LIM1863)
Colon cancer cell (SW480)
Colon cancer cell (SW620)
Colorectal cancer cell (HT29)
Colorectal cancer cell (LIM1215)
Colorectal cancer cell (LIM1863)
Colorectal cancer cell (SW480)
Colorectal cancer cell (SW620)
Colorectal cancer cells (HCT116, DLD1, SW480, SW620)
Dendritic cell
Ductal parotid saliva
Embryonic kidney cell (293T)
Embryonic kidney cell (HEK293)
Embryonic stem cell derived mesenchymal stem cell
Endothelial cell (HMEC-1)
Endothelial cell (HUVEC)
Epithelial ovarian carcinoma cell (OVCAR3, OVCAR433, OVCAR5 , SKOV3)
Erythrocyte
Extravillous trophoblast cell (HTR8/SVneo)
Fibroblast (CAF19)
Foreskin fibroblasts
Glioblastoma cell (U87)
Head and neck squamous cell carcinoma (FaDu)
Hepatic stellate cell
Hepatocellular carcinoma cell (97H)
Hepatocellular carcinoma cell (Hep3B)
Hepatocellular carcinoma cell (Huh7)
Hepatocellular carcinoma cell (LM3)
Hepatoma cell (Huh-7)
Human T lymphoma cell (H9)
Human umbilical vascular endothelial cells
Immortalized prostate epithelial cell line (PNT2C2)
Immortalized prostate epithelial cell line (RWPE-1)
Keratinocyte
Kidney cancer cell (786-O)
Kidney cancer cell (A498)
Kidney cancer cell (ACHN)
Kidney cancer cell (CAKI)
Kidney cancer cell (RXF 393)
Kidney cancer cell (SN12C)
Kidney cancer cell (TK-10)
Kidney cancer cell (UO-31)
Leukemia cell (CCRF-CEM)
Leukemia cell (HL-60)
Leukemia cell (K562)
Leukemia cell (MOLT-4)
Leukemia cell (RPMI-8226)
Leukemia cell (SR)
Lung cancer cell (A549)
Lung cancer cell (EKVX)
Lung cancer cell (HOP-62)
Lung cancer cell (HOP-92)
Lung cancer cell (NCI-H226)
Lung cancer cell (NCI-H23)
Lung cancer cell (NCI-H322M)
Lung cancer cell (NCI-H460)
Lung cancer cell (NCI-H522)
Lung cancer pleural effusion
Macrophage (THP1)
Mammary luminal epithelial cell (C5.2)
Mammary luminal epithelial cell (HB4a)
Mast cell (HMC-1)
Melanocyte
Melanoma cell (1205Lu)
Melanoma cell (501mel)
Melanoma cell (A375M)
Melanoma cell (B16-F10, SK-MEL-202, SK-MEL035, SK-MEL-265)
Melanoma cell (Daju)
Melanoma cell (G1)
Melanoma cell (LOX IMVI)
Melanoma cell (M14)
Melanoma cell (MALME-3M)
Melanoma cell (MDA-MB-435)
Melanoma cell (MNT-1)
Melanoma cell (SK-MEL-2)
Melanoma cell (SK-MEL-28)
Melanoma cell (SK-MEL-5)
Melanoma cell (SKMEL28)
Melanoma cell (UACC-257)
Melanoma cell (UACC-62)
Mesenchymal stem cell
Mesothelioma cell (JO38)
Mesothelioma cell (JU77)
Mesothelioma cell (LO68)
Mesothelioma cell (OLD1612)
Middle-ear epithelial cell (HMEEC-1)
Monocyte (THP-1)
Monocyte-derived macrophage
Monocyte-derived macrophages
Neonatal myoblast cell
Neuroblastoma cell (CHLA255)
Neuroblastoma cell (HTLA-230)
Neuroblastoma cell (IGR-N91)
Neuroblastoma cell (IGR-NB8)
Neuroblastoma cell (IMR32)
Neuroblastoma cell (LAN-1)
Neuroblastoma cell (M1C)
Neuroblastoma cell (SH-SY5Y)
Neuroblastoma cell (SK-N-SH)
Neuroblastoma cell (SKNBe2c)
Neutrophil
Non small cell lung cancer (A549)
Non small cell lung cancer (HCC827)
Normal B cell (BJAB)
Normal bronchial epithelial cell (HBE4)
Oral squamous cell carcinoma cell (BHY)
Osteosarcoma cell (Saos-2 ATCC HTB-85)
Ovarian cancer (HO-8910PM)
Ovarian cancer (OVCA429)
Ovarian cancer cell (IGROV1)
Ovarian cancer cell (NCI-ADR-RES)
Ovarian cancer cell (OVCAR-3)
Ovarian cancer cell (OVCAR-4)
Ovarian cancer cell (OVCAR-5)
Ovarian cancer cell (OVCAR-8)
Ovarian cancer cell (SK-OV-3)
Pancreatic ductal adenocarcinoma cell (MiaPaCa2)
Pancreatic ductal adenocarcinoma cell (Pa08C)
Pancreatic ductal adenocarcinoma cell (Pa21C)
Pancreatic ductal adenocarcinoma cell (Pa28C)
Pancreatic ductal epithelial cell (HPNE)
Peritoneal dialysis effluent
Placental villous tissue
Plasma
Platelet
Primary chronic lymphoid leukemia cell #1
Primary chronic lymphoid leukemia cell #2
Prostate cancer cell (C4, partially androgen-independent)
Prostate cancer cell (C4-2, androgen-independent)
Prostate cancer cell (C4-2B, bone metastatic)
Prostate cancer cell (DU145)
Prostate cancer cell (DuCaP)
Prostate cancer cell (LNCaP)
Prostate cancer cell (LNCaP, androgen-dependent)
Prostate cancer cell (PC-3)
Prostate cancer cell (PC3)
Prostate cancer cell (PC3467C)
Prostate cancer cell (VCaP)
Pulmonary artery endothlelial cell (HPAEC)
Red blood cell
Retinal epithelial cell (ARPE-19)
Retinal pigment epithelial cell (RPE-1)
Retinal pigment epithelium cell (ARPE-19)
Seminal plasma
Serum
Synovial fluid
T cell (Jurkat)
T-lymphocytic cell
Tabecular meshwork cell
Thymus
Trophoblast cell (Sw71)
Urinary bladder transitional cell carcinoma (FL3)
Urinary bladder transitional cell carcinoma (SLT4)
Urinary bladder transitional cell carcinoma (T24)
Urine
W8B2+ cardiac stem cell
Whole blood
By sample status
100K population
20K population
4R0N Tau-overexpressed
Activated_exosomes
Activated_microvesicles
Androgen-deprived
Antibody-mediated rejection
Apoptotic_exosomes
Apoptotic_microvesicles
Bioreactor culture
CD63-CRISPR
Cell-mediated rejection
Centrifugation
Cocultured with C. albicans
Colorectal cancer
Control_24 h
Control_48 h
Control_exosomes
Control_microvesicles
Cystinuria patients, molecular weight fractionation
Cystinuria patients, pI fractionation
Deoxyelephantopin (DET)-treated
Deoxyelephantopin derivative-35 (DETD-35)-treated
Differential centrifugation_Exosomes
Differential centrifugation_Microvesicles
Dihydrotestosterone-treated
Docetaxel-resistant
Docetaxel-sensitive
Doxorubicin-treated
Ectosome
Exosome
Exosomes
F3-100K
F3-10K
F5-100K
F5-10K
Flask culture
HIV-1-infected
Healthy
Helicobacter pylori-infected
High-grade bladder cancer
High-risk prostate cancer (Gleason score 8-9)
Hypertensive patients under chronic suppression of RAS
Influenza A virus-infected
Insulin-induced
Ionizing radiation-treated
Irradiated (6 Gy)
LPS-treated
Low-risk prostate cancer (Gleason score 6)
M. tuberculosis-infected
Microvesicle, Storage day 42
Microvesicles
Multiple myeloma
Mycobacterium tuberculosis-infected_Orbitrap
Mycobacterium tuberculosis-infected_QSTAR
Non-small cell lung cancer patient
Non-specific findings
Nontypeable Haemophilus influenzae lysate-treated_24 h
Nontypeable Haemophilus influenzae lysate-treated_48 h
Normal
Normal donors
Normal_A33 affinity purified exosomes
Normal_Density gradient
Normal_Density gradient ultracentrifufation based protocol
Normal_EpCAM affinity purification based protocol
Normal_EpCAM affinity purified exosomes
Normal_Orbitrap
Normal_Pelleting based protocol
Normal_QSTAR
Normal_low density
Normal_shed vesicles
Osteoarthritis (OA)
P. falciparum-infected
PDGF-BB-treated
Patient of developmental heart defect_exosome
Patient of developmental heart defect_microparticle
Patients of small cell lymphoma
Patients of autosomal recessive polycystic kidney disease
Patients of bladder cancer
Patients of carotid atherosclerosis
Patients of chronic lymphocytic leukemia
Patients of colorectal cancer
Patients of hernia
Preeclampsia patients
Protein organic solvent precipitation
Rheumatoid arthritis (RA)
Sequential centrifugal ultrafiltration_Exosomes
Sequential centrifugal ultrafiltration_Microvesicles
Serum-starved
Size exclusion chromatography
Stimulated by IgG
Stimulated by LPS
Stimulated by P-selectin-Ig
Stimulated in fluid phase
Stimulated in immobile phase
Stimulated with beta-glucan
Stressed (hypoxia, TNF-慣-induced activation, high glucose and mannose concentrations)
T. cruzi (metacyclic trypomastigote stage)-treated
T. gondii-infected
TGF-β-treated
Treated by PAI-1
Treated by TNF-alpha
Treated by actinomycin D
Treated by phytohemagglutinin
Tubular injury
Ultra-cushion
Ultracentrifugation
Ultrafiltration-size exclusion chromatography
Uninfected
p53 knock-down and EGFR L858R point mutation
pCMV-HA-HBx-transfected
pCMV-HBV1.1(X')-transfected
pCMV-HBV1.1-transfected
pCMV-transfected
Number of molecules in one page:
100
200
All
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Protein name
UniProt accession
Publication
Orthologous group
Identification count
All / Prokaryote / Eukaryote
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.
Sci Rep. 2017 Oct 6;7(1):12782. doi: 10.1038/s41598-017-13092-x.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.
Sci Rep. 2017 Oct 6;7(1):12782. doi: 10.1038/s41598-017-13092-x.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.
Ann Oncol. 2017 Sep 25. doi: 10.1093/annonc/mdx542.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.
Ann Oncol. 2017 Sep 25. doi: 10.1093/annonc/mdx542.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.
Ann Oncol. 2017 Sep 25. doi: 10.1093/annonc/mdx542.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.
Ann Oncol. 2017 Sep 25. doi: 10.1093/annonc/mdx542.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.
Ann Oncol. 2017 Sep 25. doi: 10.1093/annonc/mdx542.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.
Ann Oncol. 2017 Sep 25. doi: 10.1093/annonc/mdx542.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
The Human Amnion Epithelial Cell Secretome Decreases Hepatic Fibrosis in Mice with Chronic Liver Fibrosis.
Front Pharmacol. 2017 Oct 24;8:748. doi: 10.3389/fphar.2017.00748. eCollection 2017.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.
Sci Rep. 2017 Nov 10;7(1):15297. doi: 10.1038/s41598-017-15717-7.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.
Sci Rep. 2017 Nov 10;7(1):15297. doi: 10.1038/s41598-017-15717-7.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells.
FASEB J. 2017 Nov 30. pii: fj.201700248RR. doi: 10.1096/fj.201700248RR.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells.
FASEB J. 2017 Nov 30. pii: fj.201700248RR. doi: 10.1096/fj.201700248RR.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells.
FASEB J. 2017 Nov 30. pii: fj.201700248RR. doi: 10.1096/fj.201700248RR.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells.
FASEB J. 2017 Nov 30. pii: fj.201700248RR. doi: 10.1096/fj.201700248RR.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Tetraspanin CD63 bridges autophagic and endosomal processes to regulate exosomal secretion and intracellular signaling of Epstein-Barr virus LMP1.
J Virol. 2017 Dec 6. pii: JVI.01969-17. doi: 10.1128/JVI.01969-17.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Tetraspanin CD63 bridges autophagic and endosomal processes to regulate exosomal secretion and intracellular signaling of Epstein-Barr virus LMP1.
J Virol. 2017 Dec 6. pii: JVI.01969-17. doi: 10.1128/JVI.01969-17.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Hepatic stellate cell-derived PDGFRalpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.
Hepatology. 2018 Jan 23. doi: 10.1002/hep.29803.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Hepatic stellate cell-derived PDGFRalpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.
Hepatology. 2018 Jan 23. doi: 10.1002/hep.29803.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Hepatic stellate cell-derived PDGFRalpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.
Hepatology. 2018 Jan 23. doi: 10.1002/hep.29803.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
Biologically active constituents of the secretome of human W8B2(+) cardiac stem cells.
Sci Rep. 2018 Jan 25;8(1):1579. doi: 10.1038/s41598-018-19855-4.
COG0474
454
/
7
/
447
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)
P05023
AQP2 in human urine is predominantly localized to exosomes with preserved water channel activities.
Clin Exp Nephrol. 2018 Feb 2. pii: 10.1007/s10157-018-1538-6. doi: 10.1007/s10157-018-1538-6.
COG0474
454
/
7
/
447
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