This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts.
J Cell Physiol. 2007 Feb;210(2):325-35.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Characterization of vesicles secreted from insulinoma NIT-1 cells.
J Proteome Res. 2009 Jun;8(6):2851-62. doi: 10.1021/pr900009y.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice.
J Proteomics. 2011 Sep 6;74(10):2025-33. doi: 10.1016/j.jprot.2011.05.023. Epub 2011 May 19.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections.
PLoS One. 2011;6(10):e26588. doi: 10.1371/journal.pone.0026588. Epub 2011 Oct 26.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.
Cell. 2012 Dec 21;151(7):1542-56. doi: 10.1016/j.cell.2012.11.024.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.
Cancer Lett. 2015 Feb 4. pii: S0304-3835(15)00066-X. doi: 10.1016/j.canlet.2015.01.032.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
Nat Cell Biol. 2015 May 18. doi: 10.1038/ncb3169.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.
Nat Commun. 2016 Jun 15;7:11958. doi: 10.1038/ncomms11958.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion.
J Am Heart Assoc. 2016 Oct 17;5(10). pii: e004099.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner.
J Biol Chem. 2016 Dec 1. pii: jbc.M116.747618.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.
Sci Signal. 2017 Apr 4;10(473). pii: eaai7696. doi: 10.1126/scisignal.aai7696.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.
Sci Signal. 2017 Apr 4;10(473). pii: eaai7696. doi: 10.1126/scisignal.aai7696.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG5069536 / 0 / 536
Alpha-actinin-4 (Non-muscle alpha-actinin 4)P57780Exosomes as secondary inductive signals involved in kidney organogenesis.
J Extracell Vesicles. 2018 Jan 23;7(1):1422675. doi: 10.1080/20013078.2017.1422675. eCollection 2018.		COG5069536 / 0 / 536
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