This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Putative aminopeptidaseQ9JYU4Comparative proteome analysis of spontaneous outer membrane vesicles and purified outer membranes of Neisseria meningitidis.
J Bacteriol. 2013 Oct;195(19):4425-35. doi: 10.1128/JB.00625-13. Epub 2013 Jul 26.
COG0006256 / 8 / 248
Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Proline dipeptidase) (Prolidase)Q0WAP4Production of outer membrane vesicles by the plague pathogen Yersinia pestis.
PLoS One. 2014 Sep 8;9(9):e107002. doi: 10.1371/journal.pone.0107002. eCollection 2014.
COG0006256 / 8 / 248
Aminopeptidase PQ9HTW6Tracking the Dynamic Relationship between Cellular Systems and Extracellular Subproteomes in Pseudomonas aeruginosa Biofilms.
J Proteome Res. 2015 Nov 6;14(11):4524-37. doi: 10.1021/acs.jproteome.5b00262. Epub 2015 Oct 2.
COG0006256 / 8 / 248
Aminopeptidase PQ9HTW6Tracking the Dynamic Relationship between Cellular Systems and Extracellular Subproteomes in Pseudomonas aeruginosa Biofilms.
J Proteome Res. 2015 Nov 6;14(11):4524-37. doi: 10.1021/acs.jproteome.5b00262. Epub 2015 Oct 2.
COG0006256 / 8 / 248
Probable metallopeptidaseQ9HVS3Tracking the Dynamic Relationship between Cellular Systems and Extracellular Subproteomes in Pseudomonas aeruginosa Biofilms.
J Proteome Res. 2015 Nov 6;14(11):4524-37. doi: 10.1021/acs.jproteome.5b00262. Epub 2015 Oct 2.
COG0006256 / 8 / 248
Aminopeptidase PQ9HTW6Tracking the Dynamic Relationship between Cellular Systems and Extracellular Subproteomes in Pseudomonas aeruginosa Biofilms.
J Proteome Res. 2015 Nov 6;14(11):4524-37. doi: 10.1021/acs.jproteome.5b00262. Epub 2015 Oct 2.
COG0006256 / 8 / 248
Xaa-Pro aminopeptidaseA6D6K4Outer membrane vesicles containing signaling molecules and active hydrolytic enzymes released by a coral pathogen Vibrio shilonii AK1.
Environ Microbiol. 2016 Apr 21. doi: 10.1111/1462-2920.13344.
COG0006256 / 8 / 248
Putative aminopeptidase P XAA-pro aminopeptidaseQ99Y85A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus.
MBio. 2016 Nov 1;7(6). pii: e00207-16. doi: 10.1128/mBio.00207-16.
COG0006256 / 8 / 248
Putative XAA-PRO dipeptidase X-PRO dipeptidase (EC 3.4.13.9)Q9A119A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus.
MBio. 2016 Nov 1;7(6). pii: e00207-16. doi: 10.1128/mBio.00207-16.
COG0006256 / 8 / 248
Peptidase, M24 family protein (EC 3.4.-.-)Q5NH62Amino Acid Deprivation and Central Carbon Metabolism Regulate the Production of Outer Membrane Vesicles and Tubes by Francisella.
Mol Microbiol. 2017 Dec 14. doi: 10.1111/mmi.13897.
COG0006256 / 8 / 248
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