This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)B0TW32Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine.
J Proteome Res. 2011 Mar 4;10(3):954-67. doi: 10.1021/pr1009756. Epub 2011 Feb 9.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)A0A023KWH6Antibiotics and Iron-limiting conditions and their effect on the production and composition of outer membrane vesicles secreted from clinical isolates of extraintestinal pathogenic E. coli.
Proteomics Clin Appl. 2016 Sep 26. doi: 10.1002/prca.201600091.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)A0A023KWH6Antibiotics and Iron-limiting conditions and their effect on the production and composition of outer membrane vesicles secreted from clinical isolates of extraintestinal pathogenic E. coli.
Proteomics Clin Appl. 2016 Sep 26. doi: 10.1002/prca.201600091.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)A0A023KWH6Antibiotics and Iron-limiting conditions and their effect on the production and composition of outer membrane vesicles secreted from clinical isolates of extraintestinal pathogenic E. coli.
Proteomics Clin Appl. 2016 Sep 26. doi: 10.1002/prca.201600091.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)A0A023KWH6Antibiotics and Iron-limiting conditions and their effect on the production and composition of outer membrane vesicles secreted from clinical isolates of extraintestinal pathogenic E. coli.
Proteomics Clin Appl. 2016 Sep 26. doi: 10.1002/prca.201600091.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)A0A023KWH6Antibiotics and Iron-limiting conditions and their effect on the production and composition of outer membrane vesicles secreted from clinical isolates of extraintestinal pathogenic E. coli.
Proteomics Clin Appl. 2016 Sep 26. doi: 10.1002/prca.201600091.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)A0A023KWH6Antibiotics and Iron-limiting conditions and their effect on the production and composition of outer membrane vesicles secreted from clinical isolates of extraintestinal pathogenic E. coli.
Proteomics Clin Appl. 2016 Sep 26. doi: 10.1002/prca.201600091.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)P58075A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus.
MBio. 2016 Nov 1;7(6). pii: e00207-16. doi: 10.1128/mBio.00207-16.
COG048212 / 9 / 3
tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13)P25745Bacterial outer membrane vesicles suppress tumor by interferon-gamma-mediated antitumor response.
Nat Commun. 2017 Sep 20;8(1):626. doi: 10.1038/s41467-017-00729-8.
COG048212 / 9 / 3
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