This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice.
J Proteomics. 2011 Sep 6;74(10):2025-33. doi: 10.1016/j.jprot.2011.05.023. Epub 2011 May 19.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections.
PLoS One. 2011;6(10):e26588. doi: 10.1371/journal.pone.0026588. Epub 2011 Oct 26.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?
PLoS One. 2014 Jan 2;9(1):e84153. doi: 10.1371/journal.pone.0084153. eCollection 2014.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease.
PLoS One. 2014 Dec 3;9(12):e113651. doi: 10.1371/journal.pone.0113651. eCollection 2014.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.
Cancer Lett. 2015 Feb 4. pii: S0304-3835(15)00066-X. doi: 10.1016/j.canlet.2015.01.032.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
Nat Cell Biol. 2015 May 18. doi: 10.1038/ncb3169.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Adipocyte exosomes promote melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and cancer.
Cancer Res. 2016 May 23. pii: canres.0651.2016.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion.
J Am Heart Assoc. 2016 Oct 17;5(10). pii: e004099.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion.
J Am Heart Assoc. 2016 Oct 17;5(10). pii: e004099.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Thymic exosomes promote the final maturation of thymocytes.
Sci Rep. 2016 Nov 8;6:36479. doi: 10.1038/srep36479.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.
Sci Rep. 2016 Dec 5;6:37871. doi: 10.1038/srep37871.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.
Sci Rep. 2016 Dec 5;6:37871. doi: 10.1038/srep37871.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.
Sci Signal. 2017 Apr 4;10(473). pii: eaai7696. doi: 10.1126/scisignal.aai7696.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.
Sci Signal. 2017 Apr 4;10(473). pii: eaai7696. doi: 10.1126/scisignal.aai7696.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG1018447 / 3 / 444
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)P01942Exosomes as secondary inductive signals involved in kidney organogenesis.
J Extracell Vesicles. 2018 Jan 23;7(1):1422675. doi: 10.1080/20013078.2017.1422675. eCollection 2018.		COG1018447 / 3 / 444
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