This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Histone H2AX (H2a/x) (Histone H2A.X)P27661Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice.
J Proteomics. 2011 Sep 6;74(10):2025-33. doi: 10.1016/j.jprot.2011.05.023. Epub 2011 May 19.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.
Cell. 2012 Dec 21;151(7):1542-56. doi: 10.1016/j.cell.2012.11.024.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.
Biochem Biophys Res Commun. 2014 Mar 7;445(2):327-33. doi: 10.1016/j.bbrc.2014.01.183. Epub 2014 Feb 7.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.
Biochem Biophys Res Commun. 2014 Mar 7;445(2):327-33. doi: 10.1016/j.bbrc.2014.01.183. Epub 2014 Feb 7.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.
Cancer Lett. 2015 Feb 4. pii: S0304-3835(15)00066-X. doi: 10.1016/j.canlet.2015.01.032.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
Nat Cell Biol. 2015 May 18. doi: 10.1038/ncb3169.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR.
Mol Neurodegener. 2016 May 23;11(1):41. doi: 10.1186/s13024-016-0108-1.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner.
J Biol Chem. 2016 Dec 1. pii: jbc.M116.747618.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.
Sci Rep. 2016 Dec 5;6:37871. doi: 10.1038/srep37871.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.
COG5262452 / 0 / 452
Histone H2AX (H2a/x) (Histone H2A.X)P27661Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.
COG5262452 / 0 / 452
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