This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Cells release prions in association with exosomes.
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9683-8. Epub 2004 Jun 21.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts.
J Cell Physiol. 2007 Feb;210(2):325-35.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Characterization of vesicles secreted from insulinoma NIT-1 cells.
J Proteome Res. 2009 Jun;8(6):2851-62. doi: 10.1021/pr900009y.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Proteomics Clin Appl. 2007 Nov;1(11):1446-61. doi: 10.1002/prca.200700522. Epub 2007 Oct 16.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice.
J Proteomics. 2011 Sep 6;74(10):2025-33. doi: 10.1016/j.jprot.2011.05.023. Epub 2011 May 19.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections.
PLoS One. 2011;6(10):e26588. doi: 10.1371/journal.pone.0026588. Epub 2011 Oct 26.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.
Cell. 2012 Dec 21;151(7):1542-56. doi: 10.1016/j.cell.2012.11.024.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
PLoS Negl Trop Dis. 2013 May 2;7(5):e2185. doi: 10.1371/journal.pntd.0002185. Print 2013.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
PLoS Negl Trop Dis. 2013 May 2;7(5):e2185. doi: 10.1371/journal.pntd.0002185. Print 2013.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
PLoS Negl Trop Dis. 2013 May 2;7(5):e2185. doi: 10.1371/journal.pntd.0002185. Print 2013.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?
PLoS One. 2014 Jan 2;9(1):e84153. doi: 10.1371/journal.pone.0084153. eCollection 2014.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?
PLoS One. 2014 Jan 2;9(1):e84153. doi: 10.1371/journal.pone.0084153. eCollection 2014.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.
Biochem Biophys Res Commun. 2014 Mar 7;445(2):327-33. doi: 10.1016/j.bbrc.2014.01.183. Epub 2014 Feb 7.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.
Biochem Biophys Res Commun. 2014 Mar 7;445(2):327-33. doi: 10.1016/j.bbrc.2014.01.183. Epub 2014 Feb 7.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.
Cancer Lett. 2015 Feb 4. pii: S0304-3835(15)00066-X. doi: 10.1016/j.canlet.2015.01.032.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
Nat Cell Biol. 2015 May 18. doi: 10.1038/ncb3169.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Adipocyte exosomes promote melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and cancer.
Cancer Res. 2016 May 23. pii: canres.0651.2016.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR.
Mol Neurodegener. 2016 May 23;11(1):41. doi: 10.1186/s13024-016-0108-1.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.
Nat Commun. 2016 Jun 15;7:11958. doi: 10.1038/ncomms11958.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles.
Oncotarget. 2016 Jul 22. doi: 10.18632/oncotarget.10783.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles.
Oncotarget. 2016 Jul 22. doi: 10.18632/oncotarget.10783.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Mast Cell Degranulation Is Accompanied by the Release of a Selective Subset of Extracellular Vesicles That Contain Mast Cell-Specific Proteases.
J Immunol. 2016 Sep 12. pii: 1600614.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion.
J Am Heart Assoc. 2016 Oct 17;5(10). pii: e004099.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion.
J Am Heart Assoc. 2016 Oct 17;5(10). pii: e004099.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Thymic exosomes promote the final maturation of thymocytes.
Sci Rep. 2016 Nov 8;6:36479. doi: 10.1038/srep36479.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.
Sci Rep. 2016 Dec 5;6:37871. doi: 10.1038/srep37871.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.
Sci Signal. 2017 Apr 4;10(473). pii: eaai7696. doi: 10.1126/scisignal.aai7696.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-beta Protofibril Exposure of Neuroglial Co-Cultures.
J Alzheimers Dis. 2017 Aug 17. doi: 10.3233/JAD-170278.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures.
Sci Rep. 2017 Oct 3;7(1):12639. doi: 10.1038/s41598-017-13027-6.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures.
Sci Rep. 2017 Oct 3;7(1):12639. doi: 10.1038/s41598-017-13027-6.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Extracellular vesicles released by cardiomyocytes in a doxorubicin-induced cardiac injury mouse model contain protein biomarkers of early cardiac injury.
Clin Cancer Res. 2017 Oct 25. pii: clincanres.2046.2017. doi: 10.1158/1078-0432.CCR-17-2046.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Extracellular vesicles released by cardiomyocytes in a doxorubicin-induced cardiac injury mouse model contain protein biomarkers of early cardiac injury.
Clin Cancer Res. 2017 Oct 25. pii: clincanres.2046.2017. doi: 10.1158/1078-0432.CCR-17-2046.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG0443608 / 40 / 568
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)P63017Exosomes as secondary inductive signals involved in kidney organogenesis.
J Extracell Vesicles. 2018 Jan 23;7(1):1422675. doi: 10.1080/20013078.2017.1422675. eCollection 2018.		COG0443608 / 40 / 568
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