This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Characterization of vesicles secreted from insulinoma NIT-1 cells.
J Proteome Res. 2009 Jun;8(6):2851-62. doi: 10.1021/pr900009y.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice.
J Proteomics. 2011 Sep 6;74(10):2025-33. doi: 10.1016/j.jprot.2011.05.023. Epub 2011 May 19.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
PLoS Negl Trop Dis. 2013 May 2;7(5):e2185. doi: 10.1371/journal.pntd.0002185. Print 2013.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
PLoS Negl Trop Dis. 2013 May 2;7(5):e2185. doi: 10.1371/journal.pntd.0002185. Print 2013.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
Nat Cell Biol. 2015 May 18. doi: 10.1038/ncb3169.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion.
J Am Heart Assoc. 2016 Oct 17;5(10). pii: e004099.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Thymic exosomes promote the final maturation of thymocytes.
Sci Rep. 2016 Nov 8;6:36479. doi: 10.1038/srep36479.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner.
J Biol Chem. 2016 Dec 1. pii: jbc.M116.747618.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.		COG0443608 / 40 / 568
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Q61316Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-beta Protofibril Exposure of Neuroglial Co-Cultures.
J Alzheimers Dis. 2017 Aug 17. doi: 10.3233/JAD-170278.		COG0443608 / 40 / 568
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