This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts.
J Cell Physiol. 2007 Feb;210(2):325-35.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Characterization of vesicles secreted from insulinoma NIT-1 cells.
J Proteome Res. 2009 Jun;8(6):2851-62. doi: 10.1021/pr900009y.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.
Cancer Lett. 2015 Feb 4. pii: S0304-3835(15)00066-X. doi: 10.1016/j.canlet.2015.01.032.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.
Nat Commun. 2016 Jun 15;7:11958. doi: 10.1038/ncomms11958.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Thymic exosomes promote the final maturation of thymocytes.
Sci Rep. 2016 Nov 8;6:36479. doi: 10.1038/srep36479.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses.
J Extracell Vesicles. 2017 Aug 13;6(1):1359478. doi: 10.1080/20013078.2017.1359478. eCollection 2017.
COG1196177 / 2 / 175
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (XCAP-C homolog)Q8CG47Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.
COG1196177 / 2 / 175
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