This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?
PLoS One. 2014 Jan 2;9(1):e84153. doi: 10.1371/journal.pone.0084153. eCollection 2014.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk?
PLoS One. 2014 Jan 2;9(1):e84153. doi: 10.1371/journal.pone.0084153. eCollection 2014.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.
Biochem Biophys Res Commun. 2014 Mar 7;445(2):327-33. doi: 10.1016/j.bbrc.2014.01.183. Epub 2014 Feb 7.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.
Biochem Biophys Res Commun. 2014 Mar 7;445(2):327-33. doi: 10.1016/j.bbrc.2014.01.183. Epub 2014 Feb 7.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Extracellular Vesicles from Neural Stem Cells Transfer IFN-gamma via Ifngr1 to Activate Stat1 Signaling in Target Cells.
Mol Cell. 2014 Sep 16. pii: S1097-2765(14)00675-3. doi: 10.1016/j.molcel.2014.08.020.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.
Cancer Lett. 2015 Feb 4. pii: S0304-3835(15)00066-X. doi: 10.1016/j.canlet.2015.01.032.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.
Nat Cell Biol. 2015 May 18. doi: 10.1038/ncb3169.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR.
Mol Neurodegener. 2016 May 23;11(1):41. doi: 10.1186/s13024-016-0108-1.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Thymic exosomes promote the final maturation of thymocytes.
Sci Rep. 2016 Nov 8;6:36479. doi: 10.1038/srep36479.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.
Sci Signal. 2017 Apr 4;10(473). pii: eaai7696. doi: 10.1126/scisignal.aai7696.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-beta Protofibril Exposure of Neuroglial Co-Cultures.
J Alzheimers Dis. 2017 Aug 17. doi: 10.3233/JAD-170278.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		ENOG410XPKH259 / 0 / 259
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Q99P72Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		ENOG410XPKH259 / 0 / 259
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