This menu provides the list of EV proteins identified by high-throughput analyses.

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Superdomain: All Prokaryote Eukaryote
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  - "Sample type" indicates the source from which EVs originated (e.g. B cell, serum).
  - "Sample status" indicates the condition of the source from which EVs originated (e.g. Normal, miR-146a-treated, Patients of hernia).
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Protein name UniProt accession Publication Orthologous group Identification count
All / Prokaryote / Eukaryote
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9. Epub 2007 May 7.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
PLoS Negl Trop Dis. 2013 May 2;7(5):e2185. doi: 10.1371/journal.pntd.0002185. Print 2013.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
PLoS Negl Trop Dis. 2013 May 2;7(5):e2185. doi: 10.1371/journal.pntd.0002185. Print 2013.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Exosomes from myeloid-derived suppressor cells carry biologically active proteins.
J Proteome Res. 2014 Feb 7;13(2):836-43. doi: 10.1021/pr400879c. Epub 2013 Dec 13.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Membrane microvesicles as mediators for melanoma-fibroblasts communication: Roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway.
Cancer Lett. 2015 Feb 4. pii: S0304-3835(15)00066-X. doi: 10.1016/j.canlet.2015.01.032.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4A comprehensive proteomics analysis reveals a secretory path- and status-dependent signature of exosomes released from tumor associated macrophages.
J Proteome Res. 2015 Aug 27.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Cells release subpopulations of exosomes with distinct molecular and biological properties.
Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.
Nat Commun. 2016 Jun 15;7:11958. doi: 10.1038/ncomms11958.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.
Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11535.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles.
J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Hypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice.
J Proteome Res. 2017 Jun 22. doi: 10.1021/acs.jproteome.7b00144.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Proteomic profiling of exosomes secreted by breast cancer cells with varying metastatic potential.
Proteomics. 2017 Nov 8. doi: 10.1002/pmic.201600370.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG5657266 / 0 / 266
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Q9ERK4Differential content of proteins, mRNAs, and miRNAs suggests that MDSC and their exosomes may mediate distinct immune suppressive functions.
J Proteome Res. 2017 Nov 15. doi: 10.1021/acs.jproteome.7b00646.		COG5657266 / 0 / 266
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