EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Keratin-associated protein 5-9 (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (Keratin-associated protein 5.9) (UHS keratin A) (UHS KerA) (Ultrahigh sulfur keratin-associated protein 5.9)KRTAP5-9 KAP5.9 KRN1 KRTAP5.9 UHSK1P26371168
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)GAPDH GAPD CDABP0047 OK/SW-cl.12P0440669
Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]ACTG1 ACTB ACTGP6326157
Electron transfer flavoprotein subunit beta (Beta-ETF)ETFB FP585P3811748
Glutathione S-transferase P (EC (GST class-pi) (GSTP1-1)GSTP1 FAEES3 GST3P0921142
Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)EEF1A1 EEF1A EF1A LENG7P6810440
Porphobilinogen deaminase (PBG-D) (EC (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)HMBS PBGD UPSP0839739
CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)CEBPB TCF5 PP9092P1767638
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]B2M CDABP0092 HDCMA22PP6176937
HCG15971, isoform CRA_a (PS1TP5-binding protein 1)PS1TP5BP1 hCG_15971Q1KLZ037
40S ribosomal protein S3a (v-fos transformation effector protein) (Fte-1)RPS3A FTE1 MFTLP6124735
60S acidic ribosomal protein P0 (60S ribosomal protein L10E)RPLP0P0538835
Elongation factor 1-beta (EF-1-beta)EEF1B2 EEF1B EF1BP2453435
Fructose-bisphosphate aldolase A (EC (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)ALDOA ALDAP0407535
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)FKBP1A FKBP1 FKBP12P6294235
Protein ALEX (Alternative gene product encoded by XL-exon)GNAS GNAS1P8499634
60S ribosomal protein L23aRPL23AP6275033
Transcription factor BTF3 (RNA polymerase B transcription factor 3)BTF3 NACB OK/SW-cl.8P2029033
40S ribosomal protein S27 (Metallopan-stimulin 1) (MPS-1)RPS27 MPS1P4267732
60S ribosomal protein L12RPL12P3005032
60S ribosomal protein L17 (60S ribosomal protein L23) (PD-1)RPL17P1862132
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)HSPA8 HSC70 HSP73 HSPA10P1114232
60S ribosomal protein L3 (HIV-1 TAR RNA-binding protein B) (TARBP-B)RPL3 OK/SW-cl.32P3902331
Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]ACTBP6070931
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]HNRNPA1 HNRPA1P0965131
Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)HNRNPC HNRPCP0791031
Histone H3.3H3F3A H3.3A H3F3 PP781; H3F3B H3.3BP8424330
Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23)TPT1P1369330
40S ribosomal protein S29RPS29P6227329
60S acidic ribosomal protein P1RPLP1 RRP1P0538629
AP-2 complex subunit sigma (Adapter-related protein complex 2 subunit sigma) (Adaptor protein complex AP-2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)AP2S1 AP17 CLAPS2P5368029
Histone H3H3F3B H3F3A hCG_1984517 hCG_1989319B2R4P929
Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)ANXA2 ANX2 ANX2L4 CAL1H LPC2DP0735528
Ferritin heavy chain (Ferritin H subunit) (EC (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]FTH1 FTH FTHL6 OK/SW-cl.84 PIG15P0279428
Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Renal carcinoma antigen NY-REN-38)HSP90AA1 HSP90A HSPC1 HSPCAP0790028
Phosphoglycerate kinase 1 (EC (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)PGK1 PGKA MIG10 OK/SW-cl.110P0055828
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]LMNA LMN1P0254528
Cell division control protein 42 homolog (G25K GTP-binding protein)CDC42P6095327
Citrate synthase, mitochondrial (EC
Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)DYNLRB1 BITH DNCL2A DNLC2A ROBLD1 HSPC162Q9NP9727
Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2)HMGN2 HMG17P0520427
Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain)TUBA1BP6836327
60S ribosomal protein L41 (HG12)RPL41P6294526
ATP synthase subunit e, mitochondrial (ATPase subunit e)ATP5I ATP5KP5638526
CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)CD44 LHR MDU2 MDU3 MIC4P1607026
CDKN1A protein (Cyclin-dependent kinase inhibitor 1A) (Cyclin-dependent kinase inhibitor 1A (P21, Cip1)) (Cyclin-dependent kinase inhibitor 1A (P21, Cip1), isoform CRA_a)CDKN1A hCG_15367Q6FI0526
Eukaryotic translation initiation factor 4B (eIF-4B)EIF4BP2358826
Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)HNRNPAB ABBP1 HNRPABQ9972926
Histone H4HIST1H4L HIST1H4JB2R4R026
Matrin-3MATR3 KIAA0723P4324326
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)STAT1P4222426
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3A) (Smt3A)SUMO2 SMT3A SMT3H2P6195626
Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog)TAGLN2 KIAA0120 CDABP0035P3780226
60S ribosomal protein L22 (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15)RPL22P3526825
60S ribosomal protein L7RPL7P1812425
ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)ATP5DP3004925
Caspase-8 (CASP-8) (EC (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]CASP8 MCH5Q1479025
Clathrin light chain A (Lca)CLTAP0949625
High mobility group protein B1 (High mobility group protein 1) (HMG-1)HMGB1 HMG1P0942925
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]PPIA CYPAP6293725
Protein CDV3 homologCDV3 H41Q9UKY725
Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR)TSPO BZRP MBRP3053625
Adenylate kinase 2, mitochondrial (AK 2) (EC (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]AK2 ADK2P5481924
ADP-ribosylation factor 1ARF1P8407724
ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase proteolipid P2) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C2) (ATPase protein 9) (ATPase subunit c)ATP5G2 PSEC0033Q0605524
Deoxyguanosine kinase, mitochondrial (dGK) (EC DGKQ1685424
Destrin (Actin-depolymerizing factor) (ADF)DSTN ACTDP DSNP6098124
Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle-specific gene M9 protein) (PLAC-24) (eIF-3 p25) (eIF-3 p28)EIF3K EIF3S12 ARG134 HSPC029 MSTP001 PTD001Q9UBQ524
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)HNRNPD AUF1 HNRPDQ1410324
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)HNRNPUL1 E1BAP5 HNRPUL1Q9BUJ224
Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)KPNB1 NTF97Q1497424
Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II)MT2A CES1 MT2P0279524
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)TNPO1 KPNB2 MIP1 TRNQ9297324
Ubiquitin-conjugating enzyme E2 D3 (EC (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)UBE2D3 UBC5C UBCH5CP6107724
Ubiquitin-like protein FUBIFAUP3554424
60S ribosomal protein L13 (Breast basic conserved protein 1)RPL13 BBC1 OK/SW-cl.46P2637323
60S ribosomal protein L13a (23 kDa highly basic protein)RPL13AP4042923
60S ribosomal protein L14 (CAG-ISL 7)RPL14P5091423
60S ribosomal protein L34RPL34P4920723
60S ribosomal protein L4 (60S ribosomal protein L1)RPL4 RPL1P3657823
Apolipoprotein E (Apo-E)APOEP0264923
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1)CHMP2A BC2 CHMP2O4363323
Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)COX5BP1060623
Eukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1)EIF1 SUI1P4156723
Hemoglobin, betaHBBD9YZU523
Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)ITGB1 FNRB MDF2 MSK12P0555623
Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein)LRRFIP1 GCF2 TRIPQ32MZ423
Neuroblastoma breakpoint family member 11NBPF11Q86T7523
Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)NAP1L1 NRPP5520923
Protein JTB (Jumping translocation breakpoint protein) (Prostate androgen-regulated protein) (PAR protein)JTB HSPC222O7609523
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)RHOQ ARHQ RASL7A TC10P1708123
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)YWHAQP2734822
40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3)RPS2 RPS4P1588022
40S ribosomal protein S6 (Phosphoprotein NP33)RPS6 OK/SW-cl.2P6275322
40S ribosomal protein S9RPS9P4678122
60S ribosomal protein L38RPL38P6317322
Adenine phosphoribosyltransferase (APRT) (EC
ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)ATP5C1 ATP5C ATP5CL1P3654222
ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6)ATP5J ATP5A ATPMP1885922
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