EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
C-terminal-binding protein 2 (CtBP2)CTBP2P5654522
Choriogonadotropin subunit beta (CG-beta) (Chorionic gonadotrophin chain beta)CGB CGB3; CGB5; CGB7; CGB8P0123322
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)H2AFY MACROH2A1O7536722
Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4)EEF1D EF1DP2969222
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)EIF3F EIF3S5O0030322
Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)HNRNPA3 HNRPA3P5199122
MHC class II antigenHLA-DRB1D7RIH822
Protein tyrosine phosphatase type IVA 2 (EC (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)PTP4A2 PRL2 PTPCAAX2 BM-008Q1297422
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)RTN4 KIAA0886 NOGO My043 SP1507Q9NQC322
40S ribosomal protein S16RPS16P6224921
Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)ARPC4 ARC20P5999821
Alpha/beta hydrolase domain-containing protein 17A (EC 3.-.-.-)ABHD17A C19orf27 FAM108A1Q96GS621
ATP synthase subunit g, mitochondrial (ATPase subunit g)ATP5LO7596421
Cartilage-associated proteinCRTAP CASPO7571821
Catenin beta-1 (Beta-catenin)CTNNB1 CTNNB OK/SW-cl.35 PRO2286P3522221
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)CDC16 ANAPC6Q1304221
Deoxyhypusine synthase (DHS) (EC DSP4936621
Double-stranded RNA-binding protein Staufen homolog 1STAU1 STAUO9579321
Eukaryotic translation initiation factor 5 (eIF-5)EIF5P5501021
Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)HINT1 HINT PKCI1 PRKCNH1P4977321
Leucine carboxyl methyltransferase 1 (EC (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1)LCMT1 LCMT CGI-68Q9UIC821
Mitotic checkpoint protein BUB3BUB3O4368421
Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2)PCBP2Q1536621
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)PTBP1 PTBP2659921
RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2)RBMS1 C2orf12 MSSP MSSP1 SCR2P2955821
Uncharacterized protein C20orf24 (Rab5-interacting protein) (RIP5)C20orf24 PNAS-11Q9BUV821
Zinc finger protein 207ZNF207O4367021
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]YWHABP3194620
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)PSMD4 MCB1P5503620
60S ribosomal protein L31RPL31P6289920
Actin-related protein 3 (Actin-like protein 3)ACTR3 ARP3P6115820
Akirin-1AKIRIN1 C1orf108Q9H9L720
BRCA1-A complex subunit BRE (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein)BRE BRCC45Q9NXR720
Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein)CACYBP S100A6BP SIP PNAS-107Q9HB7120
CCR4-NOT transcription complex subunit 7 (EC (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)CNOT7 CAF1Q9UIV120
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)CFL1 CFLP2352820
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)COX4I1 COX4P1307320
DNA excision repair protein ERCC-1ERCC1P0799220
Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) (hMtr3) (p11)EXOSC6 MTR3Q5RKV620
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)CSE1L CAS XPO2P5506020
Gamma-adducin (Adducin-like protein 70)ADD3 ADDLQ9UEY820
Matrix-remodeling-associated protein 7 (Transmembrane anchor protein 1)MXRA7 TMAP1P8415720
Peroxiredoxin-5, mitochondrial (EC (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)PRDX5 ACR1 SBBI10P3004420
Proteasome subunit alpha type-1 (EC (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)PSMA1 HC2 NU PROS30 PSC2P2578620
Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)SETQ0110520
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]PTMA TMSAP0645420
Pyruvate kinase PKM (EC (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58)PKM OIP3 PK2 PK3 PKM2P1461820
Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC (61E3.4) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein)SMG1 ATX KIAA0421 LIPQ96Q1520
V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1)ATP6V0E1 ATP6H ATP6V0EO1534220
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)YWHAZP6310419
40S ribosomal protein S10RPS10P4678319
Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)DBIP0710819
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC; Methenyltetrahydrofolate cyclohydrolase (EC]MTHFD2 NMDMCP1399519
BolA-like protein 2BOLA2 BOLA2A My016; BOLA2BQ9H3K619
DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2)DAZAP2 KIAA0058Q1503819
DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)DCAF7 HAN11 WDR68P6196219
Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1)DEDD DEDPRO1 DEFT KE05O7561819
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC (dUTP pyrophosphatase)DUTP3331619
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC (ATP-dependent RNA helicase eIF4A-1)EIF4A1 DDX2A EIF4AP6084219
Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)FHL2 DRAL SLIM3Q1419219
Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)HDGF HMG1L2P5185819
Histone H2A type 2-A (Histone H2A.2) (Histone H2A/o)HIST2H2AA3 H2AFO HIST2H2AA; HIST2H2AA4Q6FI1319
Iduronate 2-sulfatase (EC (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain]IDS SIDSP2230419
Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)ILF3 DRBF MPHOSPH4 NF90Q1290619
L-lactate dehydrogenase A chain (LDH-A) (EC (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)LDHA PIG19P0033819
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC (Red cell acid phosphatase 1)ACP1P2466619
Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1)SERBP1 PAIRBP1 CGI-55Q8NC5119
Protein arginine N-methyltransferase 2 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT2) (EC HMT1 HRMT1L1P5534519
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)MAX BHLHD4P6124419
Protein S100-A13 (S100 calcium-binding protein A13)S100A13Q9958419
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)EWSR1 EWSQ0184419
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)SNRPN HCERN3 SMNP6316219
Tubulin beta chain (Tubulin beta-5 chain)TUBB TUBB5 OK/SW-cl.56P0743719
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)UBE2L6 UBCH8O1493319
Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)USF2 BHLHB12Q1585319
39S ribosomal protein L33, mitochondrial (L33mt) (MRP-L33)MRPL33 C2orf1O7539418
40S ribosomal protein S15aRPS15A OK/SW-cl.82P6224418
40S ribosomal protein S24RPS24P6284718
40S ribosomal protein S25RPS25P6285118
40S ribosomal protein S26RPS26P6285418
60 kDa heat shock protein, mitochondrial (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)HSPD1 HSP60P1080918
Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)ARPC2 ARC34 PRO2446O1514418
Alpha-enolase (EC (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)ENO1 ENO1L1 MBPB1 MPB1P0673318
Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)SIVA1 SIVAO1530418
ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)ATP5F1P2453918
ATP-dependent RNA helicase DDX3X (EC (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (Helicase-like protein 2) (HLP2)DDX3X DBX DDX3O0057118
Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105Q1444418
Casein kinase I isoform delta (CKI-delta) (CKId) (EC (Tau-protein kinase CSNK1D) (EC HCKIDP4873018
Caspase-2 (CASP-2) (EC (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]CASP2 ICH1 NEDD2P4257518
Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIc)COX7CP1595418
EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)EHD1 PAST PAST1 CDABP0131Q9H4M918
Eukaryotic translation elongation factor 1 delta (Guanine nucleotide exchange protein), isoform CRA_bEEF1D hCG_1994718D3DWK118
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)EIF1AX EIF1A EIF4CP4781318
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)EIF3A EIF3S10 KIAA0139Q1415218
Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)EIF3M HFLB5 PCID1 GA17 PNAS-125Q7L2H718
Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97)EIF4G2 DAP5 OK/SW-cl.75P7834418
Fragile X mental retardation syndrome-related protein 1 (hFXR1p)FXR1P5111418
FXYD domain-containing ion transport regulator 5 (Dysadherin)FXYD5 DYSAD IWU1 HSPC113 UNQ2561/PRO6241Q96DB918
GTP-binding protein Rheb (Ras homolog enriched in brain)RHEB RHEB2Q1538218
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