EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5GNG5 GNGT5P6321816
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)HSP90AB1 HSP90B HSPC2 HSPCBP0823816
Hemoglobin, gamma AHBG1D9YZU816
Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)HNRNPDL HNRPDL JKTBPO1497916
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)HNRNPA2B1 HNRPA2B1P2262616
Histone H2A.Z (H2A/z)H2AFZ H2AZP0C0S516
Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3)IVNS1ABP ARA3 FLARA3 KIAA0850 NS1 NS1BP HSPC068Q9Y6Y016
Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D)IFITM2Q0162916
Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)KRT10 KPPP1364516
Keratin-associated protein 2-4 (High sulfur keratin-associated protein 2.4) (Keratin-associated protein 2.4)KRTAP2-4 KAP2.4 KRTAP2.4Q9BYR916
Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1)LUC7L3 CREAP1 CROP O48O9523216
Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20)TOMM20 KIAA0016Q1538816
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)MPRIP KIAA0864 MRIP RHOIP3Q6WCQ116
Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C (PPIase A-like 4A) (EC (Chromosome 1-amplified sequence 2) (COAS-2) (Cyclophilin homolog overexpressed in liver cancer)PPIAL4A COAS2; PPIAL4B; PPIAL4CQ9Y53616
Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2)PSMG1 C21LRP DSCR2 PAC1O9545616
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)DIAPH1 DIAP1O6061016
Prothymosin, alpha (Prothymosin, alpha (Gene sequence 28) variant) (Putative uncharacterized protein PTMAP7) (cDNA, FLJ94794, highly similar to Homo sapiens prothymosin, alpha (gene sequence 28) (PTMA), mRNA)PTMAP7 PTMAQ53S2416
Putative ribonucleaseYBEY C21orf57P5855716
Ras-related protein Rab-2ARAB2A RAB2P6101916
Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)UPF3A RENT3A UPF3Q9H1J116
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)RHOC ARH9 ARHCP0813416
RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)RBM25 RNPC7P4975616
S-formylglutathione hydrolase (FGH) (EC (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC (EC
Small acidic proteinSMAP C11orf58O0019316
Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)ATP1B3P5470916
Sorcin (22 kDa protein) (CP-22) (CP22) (V19)SRIP3062616
Sorting nexin-3 (Protein SDP3)SNX3O6049316
Squalene synthase (SQS) (SS) (EC (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase)FDFT1P3726816
Src substrate cortactin (Amplaxin) (Oncogene EMS1)CTTN EMS1Q1424716
SUZ domain-containing protein 1 (Putative MAPK-activating protein PM18/PM20/PM22)SZRD1 C1orf144Q7Z42216
Transaldolase (EC TAL TALDO TALDORP3783716
Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1)TFDP1 DP1Q1418616
Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)YY1 INO80SP2549016
Triosephosphate isomerase (TIM) (EC (Triose-phosphate isomerase)TPI1 TPIP6017416
Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)TPM4P6793616
Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain)TUBA1C TUBA6Q9BQE316
Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B)TBCB CG22 CKAP1Q9942616
Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)UBE3A E6AP EPVE6AP HPVE6AQ0508616
Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein)URI1 C19orf2 NNX3 PPP1R19 RMP URIO9476316
UTP--glucose-1-phosphate uridylyltransferase (EC (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase)UGP2 UGP1Q1685116
V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)ATP6V1E1 ATP6E ATP6E2P3654316
Vascular endothelial zinc finger 1 (Putative transcription factor DB1) (Zinc finger protein 161)VEZF1 DB1 ZNF161Q1411916
3-hydroxyacyl-CoA dehydrogenase type-2 (EC (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)HSD17B10 ERAB HADH2 MRPP2 SCHAD XH98G2Q9971415
39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21)MRPL21Q7Z2W915
40S ribosomal protein S11RPS11P6228015
40S ribosomal protein S5 [Cleaved into: 40S ribosomal protein S5, N-terminally processed]RPS5P4678215
60S ribosomal protein L18RPL18Q0702015
60S ribosomal protein L24 (60S ribosomal protein L30)RPL24P8373115
Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29)ANP32B APRIL PHAPI2Q9268815
Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II)LYPLA2 APT2O9537215
Adenylyl cyclase-associated protein 1 (CAP 1)CAP1 CAPQ0151815
ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)GGA2 KIAA1080Q9UJY415
Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase)AKR7A2 AFAR AFAR1 AKR7O4348815
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)ACTN1P1281415
Antizyme inhibitor 1 (AZI) (Ornithine decarboxylase antizyme inhibitor)AZIN1 OAZI OAZINO1497715
AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 subunit sigma-1B) (Adaptor protein complex AP-1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin)AP1S2 DC22P5637715
ATP synthase subunit s-like proteinATP5SLQ9NW8115
ATP-citrate synthase (EC (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)ACLYP5339615
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)CTBP1 CTBPQ1336315
Calpastatin (Calpain inhibitor) (Sperm BS-17 component)CASTP2081015
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]PRKAR1A PKR1 PRKAR1 TSE1P1064415
Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)CTNNA1P3522115
CGG triplet repeat-binding protein 1 (CGG-binding protein 1) (20 kDa CGG-binding protein) (p20-CGGBP DNA-binding protein)CGGBP1 CGGBPQ9UFW815
Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)CIRBP A18HNRNP CIRPQ1401115
Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)COX5AP2067415
Cytosolic acyl coenzyme A thioester hydrolase (EC (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)ACOT7 BACHO0015415
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)DDR2 NTRKR3 TKT TYRO10Q1683215
Dolichol-phosphate mannosyltransferase subunit 3 (DPM synthase complex subunit 3) (Dolichol-phosphate mannose synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) (Prostin-1)DPM3Q9P2X015
Dual specificity protein phosphatase 4 (EC (EC (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)DUSP4 MKP2 VH2Q1311515
E3 ubiquitin-protein ligase CCNB1IP1 (EC 6.3.2.-) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10)CCNB1IP1 C14orf18 HEI10Q9NPC315
E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272Q7Z6Z715
E3 ubiquitin-protein ligase makorin-1 (EC 6.3.2.-) (RING finger protein 61)MKRN1 RNF61Q9UHC715
Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)EEF1G EF1G PRO1608P2664115
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]EIF4A3 DDX48 KIAA0111P3891915
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)EIF5AP6324115
Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2)EIF5B IF2 KIAA0741O6084115
Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2)FEZ2Q9UHY815
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)GRIN1 NMDAR1Q0558615
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC (Serine/threonine-protein kinase GSK3B) (EC
Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)GOLGA2Q0837915
H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)NHP2 NOLA2 HSPC286Q9NX2415
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)HGS HRSO1496415
High-mobility group nucleosome binding domain 1HMGN1Q6NSG715
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)HIST1H3A H3FA; HIST1H3B H3FL; HIST1H3C H3FC; HIST1H3D H3FB; HIST1H3E H3FD; HIST1H3F H3FI; HIST1H3G H3FH; HIST1H3H H3FK; HIST1H3I H3FF; HIST1H3J H3FJP6843115
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)RBBP4 RBAP48Q0902815
Inverted formin-2 (HBEBP2-binding protein C)INF2 C14orf151 C14orf173Q27J8115
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)IDH1 PICDO7587415
Kinesin-like protein KIF1B (Klp)KIF1B KIAA0591 KIAA1448O6033315
Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed]KIF3B KIAA0359O1506615
LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)LMO4P6196815
MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like)MAPK1IP1L C14orf32Q8NDC015
Metallothionein-1H (MT-1H) (Metallothionein-0) (MT-0) (Metallothionein-IH) (MT-IH)MT1HP8029415
Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC (Microsomal GST-I)MGST1 GST12 MGSTP1062015
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)MACF1 ABP620 ACF7 KIAA0465 KIAA1251Q9UPN315
Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein)MDK MK1 NEGF2P2174115
MORF4 family-associated protein 1-like 1MRFAP1L1 PP784Q96HT815
NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC (Diaphorase-1) [Cleaved into: NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form]CYB5R3 DIA1P0038715
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