EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)NAMPT PBEF PBEF1P4349015
NPC-A-16 (Ribosomal protein L9) (Ribosomal protein L9 isoform) (Ribosomal protein L9, isoform CRA_b) (cDNA, FLJ92535, Homo sapiens ribosomal protein L9 (RPL9), mRNA)RPL9 hCG_37461Q53Z0715
Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2)NFYCQ1395215
Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1)YBX1 NSEP1 YB1P6780915
PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF)KIAA0101 NS5ATP9 PAF L5Q1500415
Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]PEBP1 PBP PEBPP3008615
Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)PLEKHB2 EVT2Q96CS715
Prefoldin subunit 5 (C-Myc-binding protein Mm-1) (Myc modulator 1)PFDN5 MM1 PFD5Q9947115
Proteasome subunit beta type-4 (EC (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)PSMB4 PROS26P2807015
Protein AF-17 (ALL1-fused gene from chromosome 17 protein)MLLT6 AF17P5519815
Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)PRRC2A BAT2 G2P4863415
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]S100A11 MLN70 S100CP3194915
Putative adenosylhomocysteinase 2 (AdoHcyase 2) (EC (DC-expressed AHCY-like molecule) (S-adenosyl-L-homocysteine hydrolase 2) (S-adenosylhomocysteine hydrolase-like protein 1)AHCYL1 DCAL XPVKONAO4386515
RAC-alpha serine/threonine-protein kinase (EC (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)AKT1 PKB RACP3174915
Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)LAMTOR5 HBXIP XIPO4350415
RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)RBM4 RBM4AQ9BWF315
S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]AMD1 AMDP1770715
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)ATP2A2 ATP2BP1661515
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)PPP2R5EQ1653715
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]PPP6C PPP6O0074315
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)SHC1 SHC SHCAP2935315
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)SUMO1 SMT3C SMT3H3 UBL1 OK/SW-cl.43P6316515
Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4)SYTL2 KIAA1597 SGA72M SLP2 SLP2AQ9HCH515
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP)TXN TRDX TRX TRX1P1059915
Thymosin beta-15A (NB thymosin beta) (Thymosin-like protein 8)TMSB15A TMSL8 TMSNBP0CG3415
Transcription factor E2F6 (E2F-6)E2F6O7546115
Transmembrane protein 134TMEM134Q9H6X415
Transmembrane protein 230TMEM230 C20orf30 HSPC274 UNQ2432/PRO4992Q96A5715
Tyrosine-protein phosphatase non-receptor type 11 (EC (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)PTPN11 PTP2C SHPTP2Q0612415
U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)SNRNP70 RNPU1Z RPU1 SNRP70 U1AP1P0862115
Ubiquitin-conjugating enzyme E2 E3 (EC (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)UBE2E3 UBCE4 UBCH9Q969T415
Ubiquitin-conjugating enzyme E2 N (EC (Bendless-like ubiquitin-conjugating enzyme) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)UBE2N BLUP6108815
UMP-CMP kinase (EC (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)CMPK1 CMK CMPK UCK UMK UMPKP3008515
V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (Vacuolar proton pump 16 kDa proteolipid subunit)ATP6V0C ATP6C ATP6L ATPLP2744915
Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)VPS35 MEM3 TCCCTA00141Q96QK115
Very-long-chain enoyl-CoA reductase (EC (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)TECR GPSN2 SC2Q9NZ0115
Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein)ZMAT3 PAG608 WIG1Q9HA3815
28S ribosomal protein S12, mitochondrial (MRP-S12) (S12mt) (MT-RPS12)MRPS12 RPMS12 RPSM12O1523514
40S ribosomal protein S20RPS20P6086614
40S ribosomal protein S7RPS7P6208114
60S acidic ribosomal protein P2 (Renal carcinoma antigen NY-REN-44)RPLP2 D11S2243E RPP2P0538714
60S ribosomal protein L36RPL36Q9Y3U814
Acyl-CoA desaturase (EC (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase)SCDO0076714
ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)GGA1Q9UJY514
Alanine--tRNA ligase, cytoplasmic (EC (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42)AARSP4958814
All-trans retinoic acid-induced differentiation factor (Apoptosis-related protein 3) (APR-3) (p18)ATRAID APR3 C2orf28 HSPC013 UNQ214/PRO240Q6UW5614
Amyloid beta A4 protein (ABPP) (APPI) (APP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]APP A4 AD1P0506714
Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)ANAPC5 APC5Q9UJX414
AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin)AP3D1 PRO0039O1461714
ATP synthase F(0) complex subunit C1, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase proteolipid P1) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C1) (ATPase protein 9) (ATPase subunit c)ATP5G1P0549614
ATP synthase subunit beta, mitochondrial (EC ATPMB ATPSBP0657614
ATP-dependent RNA helicase DDX24 (EC (DEAD box protein 24)DDX24Q9GZR714
Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein)BCL2L12 BPRQ9HB0914
Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC CK1G2P7836814
Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9)CNBP RNF163 ZNF9P6263314
Clusterin-associated protein 1 (Qilin)CLUAP1 KIAA0643Q96AJ114
Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33)C1QBP GC1QBP HABP1 SF2P32Q0702114
Cyclin-G-associated kinase (EC
Cytochrome b5 (Microsomal cytochrome b5 type A) (MCB5)CYB5A CYB5P0016714
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)ADAM15 MDC15Q1344414
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC POLR2P2492814
DnaJ homolog subfamily C member 8 (Splicing protein spf31)DNAJC8 SPF31 HSPC315 HSPC331O7593714
E3 ubiquitin-protein ligase TTC3 (EC 6.3.2.-) (Protein DCRR1) (RING finger protein 105) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)TTC3 DCRR1 RNF105 TPRDP5380414
Epidermal growth factor receptor (EC (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)EGFR ERBB ERBB1 HER1P0053314
ER lumen protein retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)KDELR2 ERD2.2P3394714
Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75)KHSRP FUBP2Q9294514
Fas-activated serine/threonine kinase (FAST kinase) (EC
Growth arrest-specific protein 7 (GAS-7)GAS7 KIAA0394O6086114
Growth hormone-inducible transmembrane protein (Dermal papilla-derived protein 2) (Mitochondrial morphology and cristae structure 1) (MICS1) (Transmembrane BAX inhibitor motif-containing protein 5)GHITM DERP2 MICS1 TMBIM5 My021 UNQ244/PRO281Q9H3K214
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2)HSPA4 APG2P3493214
Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13)HSBP1 HSF1BPO7550614
Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)SYNCRIP HNRPQ NSAP1O6050614
Histamine N-methyltransferase (HMT) (EC
Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)SAP18 GIG38O0042214
HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)BBX HBP2Q8WY3614
Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2)HSPBP1 HSPBP PP1845Q9NZL414
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]CDC37 CDC37AQ1654314
Integrin beta-5ITGB5P1808414
Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9)KLF6 BCD1 COPEB CPBP ST12Q9961214
Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38)LATO4356114
Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)METAP2 MNPEP P67EIF2P5057914
Niban-like protein 1 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Protein FAM129B)FAM129B C9orf88Q96TA114
Ornithine decarboxylase antizyme 1 (ODC-Az)OAZ1 OAZP5436814
PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)PDLIM5 ENH L9Q96HC414
Peroxisomal membrane protein 2 (22 kDa peroxisomal membrane protein)PXMP2 PMP22Q9NR7714
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)PHF21A BHC80 KIAA1696 BM-006Q96BD514
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC (EC (EC (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)PTEN MMAC1 TEP1P6048414
Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29)SYF2 CBPIN GCIPIPO9592614
Proteasome subunit beta type-1 (EC (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain)PSMB1 PSC5P2061814
Protein C19orf12C19orf12Q9NSK714
Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A)LSM14A C19orf13 FAM61A RAP55 RAP55AQ8ND5614
RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6Q9966614
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)G3BP2 KIAA0660Q9UN8614
Ras-related C3 botulinum toxin substrate 1 (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)RAC1 TC25 MIG5P6300014
Ras-related protein R-Ras2 (Ras-like protein TC21) (Teratocarcinoma oncogene)RRAS2 TC21P6207014
Ras-related protein Rab-27A (Rab-27) (GTP-binding protein Ram)RAB27A RAB27P5115914
Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2)UPF2 KIAA1408 RENT2Q9HAU514
Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14)RRP7A CGI-96Q9Y3A414
RPL21 protein (Ribosomal protein L21) (Ribosomal protein L21, isoform CRA_a) (cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA)RPL21 hCG_2020044Q6IAX214
Scaffold attachment factor B2 (SAF-B2)SAFB2 KIAA0138Q1415114
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