EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)PCF11 KIAA0824O949132
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225O754002
Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25)CWC25 CCDC49Q9NXE82
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)XAB2 HCNP KIAA1177 SYF1 PP3898Q9HCS72
Prefoldin subunit 2PFDN2 PFD2 HSPC231Q9UHV92
Prefoldin subunit 6 (Protein Ke2)PFDN6 HKE2 PFD6O152122
Pregnancy-specific beta-1-glycoprotein 11 (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific beta-1-glycoprotein 13) (PS-beta-G-13) (PSBG-13) (Pregnancy-specific glycoprotein 13)PSG11 PSG13 PSG14Q9UQ722
Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7)PSG9 PSG11Q008872
PRELI domain-containing protein 2PRELID2Q8N9452
Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1)PRICKLE1 RILPQ96MT32
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]CTSH CPSBP096682
Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVF (Neuropeptide RFRP-3)]NPVF C7orf9 RFRPQ9HCQ72
Pro-neuregulin-3, membrane-bound isoform (Pro-NRG3) [Cleaved into: Neuregulin-3 (NRG-3)]NRG3P569752
Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)]NRG4Q8WWG12
Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]NPYP013032
Probable allantoicase (EC 3.5.3.4) (Allantoate amidinohydrolase)ALLCQ8N6M52
Probable ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (Probable ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)DHX58 D11LGP2E LGP2Q96C102
Probable C-mannosyltransferase DPY19L4 (EC 2.4.1.-) (Dpy-19-like protein 4) (Protein dpy-19 homolog 4)DPY19L4Q7Z3882
Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1)ATP13A3 AFURS1Q9H7F02
Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)CARS2 OK/SW-cl.10Q9HA772
Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)LDHDQ86WU22
Probable E3 ubiquitin-protein ligase HECTD2 (EC 6.3.2.-) (HECT domain-containing protein 2)HECTD2Q5U5R92
Probable E3 ubiquitin-protein ligase HERC6 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 6)HERC6Q8IVU32
Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (Tripartite motif-containing protein 1)MID2 FXY2 RNF60 TRIM1Q9UJV32
Probable E3 ubiquitin-protein ligase TRIM8 (EC 6.3.2.-) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (Tripartite motif-containing protein 8)TRIM8 GERP RNF27Q9BZR92
Probable exonuclease mut-7 homolog (EC 3.1.-.-) (Exonuclease 3'-5' domain-containing protein 3)EXD3 HBE269Q8N9H82
Probable G-protein coupled receptor 115 (G-protein coupled receptor PGR18)GPR115 PGR18Q8IZF32
Probable G-protein coupled receptor 125GPR125 UNQ556/PRO1113Q8IWK62
Probable G-protein coupled receptor 141 (G-protein coupled receptor PGR13)GPR141 PGR13Q7Z6022
Probable G-protein coupled receptor 148 (Brain and testis restricted GPCR) (G-protein coupled receptor PGR6)GPR148 BTR PGR6Q8TDV22
Probable G-protein coupled receptor 160 (G-protein coupled receptor GPCR1) (hGPCR1)GPR160 GPCR150Q9UJ422
Probable G-protein coupled receptor 176 (HB-954)GPR176Q144392
Probable G-protein coupled receptor 179 (Probable G-protein coupled receptor 158-like 1) (GPR158-like)GPR179 GPR158L GPR158L1Q6PRD12
Probable G-protein coupled receptor 34GPR34Q9UPC52
Probable G-protein coupled receptor 37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (Parkin-associated endothelin receptor-like receptor) (PAELR)GPR37O153542
Probable G-protein coupled receptor 97 (G-protein coupled receptor PGR26)GPR97 PGR26Q86Y342
Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase)IDNK C9orf103Q5T6J72
Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185)TARBP1 TRM3 TRP185Q133952
Probable N-acetyltransferase 8 (EC 2.3.1.-) (Camello-like protein 1)NAT8 CML1 GLA TSC501Q9UHE52
Probable N-acetyltransferase 8B (EC 2.3.1.-) (Camello-like protein 2)NAT8B CML2Q9UHF32
Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 1) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377)ZDHHC1 C16orf1 ZNF377Q8WTX92
Probable phospholipid-transporting ATPase IF (EC 3.6.3.1) (ATPase IR) (ATPase class VI type 11B)ATP11B ATPIF ATPIR KIAA0956Q9Y2G32
Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (ATPase class V type 10A) (Aminophospholipid translocase VA)ATP10A ATP10C ATPVA ATPVC KIAA0566O603122
Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (Haponin)EIF1ADQ8N9N82
Probable threonine--tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like protein 2)TARSL2A2RTX52
Probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP)OSGEP GCPL1Q9NPF42
Probable tubulin polyglutamylase TTLL1 (EC 6.-.-.-) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1)TTLL1 C22orf7O959222
Probable UDP-sugar transporter protein SLC35A4 (Solute carrier family 35 member A4)SLC35A4Q96G792
Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2)COLGALT2 C1orf17 GLT25D2 KIAA0584Q8IYK42
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3)PLOD3O605682
Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorphin (Dynorphin B-29)]PDYNP012132
Progonadoliberin-2 (Progonadoliberin II) [Cleaved into: Gonadoliberin-2 (Gonadoliberin II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II) (Luteinizing hormone-releasing hormone II) (LH-RH II); GnRH-associated peptide 2 (GnRH-associated peptide II)]GNRH2O435552
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)PDCD6IP AIP1 ALIX KIAA1375Q8WUM42
Programmed cell death 7, isoform CRA_a (U11/U12 snRNP 59K)PDCD7 hCG_23672Q6IEG32
Programmed cell death protein 2-likePDCD2LQ9BRP12
Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a)PROKR1 GPR73 PKR1Q8TCW92
Proline and serine-rich protein 1PROSER1 C13orf23 KIAA2032Q86XN72
Proline-rich nuclear receptor coactivator 2PNRC2 HSPC208Q9NPJ42
Proline-rich protein 18PRR18Q8N4B52
Proline-rich protein 24PRR24C9JVW02
Proline-rich protein 36PRR36Q9H6K52
Proline-rich protein 7 (Synaptic proline-rich membrane protein)PRR7Q8TB682
Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1)PRRT1 C6orf31 NG5Q999462
Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2)PSTPIP2Q9H9392
Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1)LEPRE1 GROS1 P3H1 PSEC0109Q32P282
Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4)LEPREL1 MLAT4 P3H2Q8IVL52
Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)LEPREL2 P3H3Q8IVL62
Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)PREP PEPP481472
Promotilin [Cleaved into: Motilin; Motilin-associated peptide (MAP)]MLNP128722
Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)PCSK6 PACE4P291222
Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7)PCSK7 LPC PC7 PC8 SPC7Q165492
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)PTGIR PRIPRP431192
Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)PTGDS PDSP412222
Proteasome subunit beta type (EC 3.4.25.1)PSMA4Q7Z4742
Protein ACN9 homolog, mitochondrialACN9 DC11Q9NRP42
Protein AHNAK2AHNAK2 C14orf78 KIAA2019Q8IVF22
Protein APCDD1-like (Adenomatosis polyposis coli down-regulated 1 protein-like)APCDD1LQ8NCL92
Protein arginine N-methyltransferase 6 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6) (Histone-arginine N-methyltransferase PRMT6) (EC 2.1.1.125)PRMT6 HRMT1L6Q96LA82
Protein Asterix (WD repeat domain 83 opposite strand) (WDR83 opposite strand)WDR83OS C19orf56 CGI-140 My006 PTD008Q9Y2842
Protein asunder homolog (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Sarcoma antigen NY-SAR-95)ASUN C12orf11 GCT1Q9NVM92
Protein atonal homolog 8 (Class A basic helix-loop-helix protein 21) (bHLHa21) (Helix-loop-helix protein hATH-6) (hATH6)ATOH8 ATH6 BHLHA21Q96SQ72
Protein boule-likeBOLL BOULEQ8N9W62
Protein broad-minded (TBC1 domain family member 32)TBC1D32 BROMI C6orf170 C6orf171Q96NH32
Protein C9orf69 (Herpes virus UL25-binding protein)C9orf69H0YL142
Protein CASC1 (Cancer susceptibility candidate gene 1 protein) (Lung adenoma susceptibility 1-like protein)CASC1 LAS1Q6TDU72
Protein CASC5 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein D40/AF15q14)CASC5 KIAA1570 KNL1Q8NG312
Protein CC2D2BCC2D2B C10orf130Q6DHV52
Protein CXorf40BCXorf40BQ96DE92
Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]DLK1 DLKP803702
Protein DGCR14 (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)DGCR14 DGCR13 DGSH DGSI ES2Q96DF82
Protein dispatched homolog 2DISP2 DISPB KIAA1742A7MBM22
Protein disulfide-isomerase A2 (EC 5.3.4.1) (Pancreas-specific protein disulfide isomerase) (PDIp)PDIA2 PDIPQ130872
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)PDIA4 ERP70 ERP72P136672
Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)TMX3 KIAA1830 TXNDC10Q96JJ72
Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)ECT2Q9H8V32
Protein EMSYEMSY C11orf30 GL002Q7Z5892
Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1)LMAN1 ERGIC53 F5F8DP492572
Protein ERGIC-53-like (ERGIC53-like protein) (Lectin mannose-binding 1-like) (LMAN1-like protein)LMAN1L ERGL UNQ2784/PRO7174Q9HAT12
Protein EURL homologEURL C21orf14 C21orf38 C21orf7 C21orf91 YG81Q9NYK62
Protein eva-1 homolog A (Protein FAM176A) (Transmembrane protein 166)EVA1A FAM176A TMEM166 SP24Q9H8M92
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