EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ret finger protein-like 4B (RING finger protein 211)RFPL4B RNF211Q6ZWI92
Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)RTN2 NSPL1O752982
Retina-specific copper amine oxidase (RAO) (EC 1.4.3.21) (Amine oxidase [copper-containing]) (Semicarbazide-sensitive amine oxidase) (SSAO)AOC2O751062
Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.36) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic)ALDH1A1 ALDC ALDH1 PUMB1P003522
Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))ALDH1A2 RALDH2O947882
Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein)RAX RXQ9Y2V32
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)RBL1P287492
Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)RXRB NR2B2P287022
Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)RXRG NR2B3P484432
Retinoid-binding protein 7 (Cellular retinoic acid-binding protein 4) (CRABP4) (CRBP4) (Cellular retinoic acid-binding protein IV) (CRABP-IV)RBP7Q96R052
Retinol dehydrogenase 10 (EC 1.1.1.300)RDH10 UNQ9375/PRO34191Q8IZV52
Retinol-binding protein 2 (Cellular retinol-binding protein II) (CRBP-II)RBP2 CRBP2P501202
Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]RBP4 PRO2222P027532
Retrograde Golgi transport protein RGP1 homologRGP1 KIAA0258Q925462
REX2, RNA exonuclease 2 homolog (S. cerevisiae) (REX2, RNA exonuclease 2 homolog (S. cerevisiae), isoform CRA_b) (cDNA, FLJ92319, highly similar to Homo sapiens REX2, RNA exonuclease 2 homolog (S. cerevisiae) (REXO2), mRNA)REXO2 hCG_38016B2R5322
RGM domain family member B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON)RGMBQ6NW402
Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma)ARHGDIGQ998192
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)ARHGAP10 GRAF2A1A4S62
Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)ARHGAP23 KIAA1501Q9P2272
Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)ARHGAP30Q7Z6I62
Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)ARHGAP33 SNX26 TCGAPO145592
Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1)ARHGAP6 RHOGAP6O431822
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)ARHGEF12 KIAA0382 LARGQ9NZN52
Rho guanine nucleotide exchange factor 16 (Ephexin-4)ARHGEF16 EPHEXIN4 NBRQ5VV412
Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF)ARHGEF25 GEFTQ86VW22
Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)ARHGEF26 SGEF HMFN1864Q96DR72
Rho guanine nucleotide exchange factor 39ARHGEF39 C9orf100Q8N4T42
Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9)ARHGEF9 ARHDH9 KIAA0424O433072
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)RHOH ARHH TTFQ156692
Rhomboid domain-containing protein 2RHBDD2 RHBDL7Q6NTF92
Ribonuclease 4 (RNase 4) (EC 3.1.27.-)RNASE4 RNS4P340962
Ribonuclease P protein subunit p14 (EC 3.1.26.5)RPP14O950592
Ribonuclease P protein subunit p38 (RNaseP protein p38) (EC 3.1.26.5)RPP38P783452
Ribonucleoprotein PTB-binding 2 (Protein raver-2)RAVER2 KIAA1579Q9HCJ32
Ribosomal protein S6 kinase (EC 2.7.11.1)RPS6KB1B4DLT42
Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)RPS6KA6 RSK4Q9UK322
Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)WDR12Q9GZL72
Ribosome biogenesis regulatory protein homologRRS1 KIAA0112 RRRQ150502
Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1)RPF1 BXDC5Q9H9Y22
Rieske domain-containing proteinRFESDQ8TAC12
RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein)RILPL2 RLP2Q969X02
RING finger protein 157RNF157 KIAA1917Q96PX12
RING finger protein 222RNF222A6NCQ92
RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C)TCEB3C TCEB3L2Q8NG572
RNA polymerase II transcription factor SIII subunit A3-like-1 (Elongin-A3-like-1) (EloA3-like-1) (Transcription elongation factor B polypeptide 3C-like-1)TCEB3CLQ3SY892
RNA polymerase II-associated protein 1RPAP1 KIAA1403Q9BWH62
RNA-binding motif protein, X-linked 2RBMX2 CGI-79Q9Y3882
RNA-binding protein 34 (RNA-binding motif protein 34)RBM34 KIAA0117P426962
RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4)RBM38 RNPC1 SEB4Q9H0Z92
RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45)RBM45 DRB1 DRBP1Q8IUH32
RNA-binding protein 48RBM48 C7orf64 HSPC304Q5RL732
RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)RBM6 DEF3P783322
RNA-binding protein NOB1 (Phosphorylation regulatory protein HP-10) (Protein ART-4)NOB1 ART4 NOB1P PSMD8BP1 MSTP158Q9ULX32
RotatinRTTNQ86VV82
RUN domain-containing protein 1RUNDC1 LP5161Q96C342
RUN domain-containing protein 3B (Rap2-binding protein 9) (Rap2-interacting protein 9) (RPIP-9)RUNDC3B RPIB9 RPIP9Q96NL02
RWD domain-containing protein 2BRWDD2B C21orf6 GL011P570602
RWD domain-containing protein 3 (RWD-containing sumoylation enhancer)RWDD3 RSUMEQ9Y3V22
Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3)SALL3 ZNF796Q9BXA92
SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor)SPDEF PDEF PSEO952382
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)ATP2A1O149832
Sarcospan (K-ras oncogene-associated protein) (Kirsten-ras-associated protein)SSPN KRAGQ147142
SARS proteinSARSQ0VGA52
SAYSvFN domain-containing protein 1SAYSD1 C6orf64Q9NPB02
Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)SCARF1 KIAA0149 SRECQ141622
Schwannomin-interacting protein 1 (SCHIP-1)SCHIP1Q9P0W52
SCRN3 proteinSCRN3Q0VDG52
SDF2 protein (Stromal cell-derived factor 2) (Stromal cell-derived factor 2, isoform CRA_c)SDF2 hCG_2039636Q6IBU42
SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF)SEC14L2 C22orf6 KIAA1186 KIAA1658O760542
Secreted and transmembrane protein 1 (Protein K-12)SECTM1 K12Q8WVN62
Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2)SFRP1 FRP FRP1 SARP2Q8N4742
Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3)SFRP5 FRP1B SARP3Q5T4F72
SecretinSCTP096832
Secretoglobin family 2B member 2 (Secretoglobin-like protein)SCGB2B2 SCGB4A2 SCGBLQ4G0G52
Secretoglobin family 3A member 1 (Cytokine HIN-1) (High in normal 1) (Pneumo secretory protein 2) (PnSP-2) (Uteroglobin-related protein 2)SCGB3A1 HIN1 PNSP2 UGRP2 UNQ629/PRO1245Q96QR12
Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4)SCAMP4Q969E22
Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (hSCAMP5)SCAMP5Q8TAC92
Seizure 6-like protein 2SEZ6L2 PSK UNQ1903/PRO4349Q6UXD52
Selenium-binding protein 1 (56 kDa selenium-binding protein) (SBP56) (SP56)SELENBP1 SBPQ132282
Selenocysteine lyase (hSCL) (EC 4.4.1.16)SCLY SCLQ96I152
Selenocysteine lyase variant (Fragment)0Q59FK22
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)EEFSEC SELBP577722
Semaphorin-3F (Sema III/F) (Semaphorin IV) (Sema IV)SEMA3FQ132752
Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)SEMA4D C9orf164 CD100 SEMAJQ928542
Semaphorin-4GSEMA4G KIAA1619Q9NTN92
Semaphorin-5BSEMA5B KIAA1445 SEMAG UNQ5867/PRO34001Q9P2832
Sentan (Protein S100-A1-like) (S100 calcium-binding protein A1-like)SNTN S100A1LA6NMZ22
Sentrin-specific protease 3 (EC 3.4.22.68) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3)SENP3 SSP3 SUSP3Q9H4L42
Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24)SEPT1 DIFF6 PNUTL3Q8WYJ62
Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1)SEPT5 PNUTL1Q997192
Septin-6SEPT6 KIAA0128 SEP2Q141412
Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2)SERINC1 KIAA1253 TDE1L TDE2 UNQ396/PRO732Q9NRX52
Serine incorporator 2 (Tumor differentially expressed protein 2-like)SERINC2 TDE2L FKSG84 UNQ263/PRO300Q96SA42
Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]HPN TMPRSS1P059812
Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)HTRA4P831052
Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]SPINK5Q9NQ382
Serine protease inhibitor Kazal-type 7 (Esophagus cancer-related gene 2 protein) (ECRG-2)SPINK7 ECG2 UNQ745/PRO1474P580622
Serine--pyruvate aminotransferase (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44)AGXT AGT1 SPATP215492
Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)STK10 LOKO948042
Serine/threonine-protein kinase 32B (EC 2.7.11.1) (Yet another novel kinase 2)STK32B YANK2 UNQ3003/PRO9744Q9NY572
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