EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Sorting nexin-18 (SH3 and PX domain-containing protein 3B) (Sorting nexin-associated Golgi protein 1)SNX18 SH3PXD3B SNAG1Q96RF02
Sorting nexin-21 (Sorting nexin L) (SNX-L)SNX21 C20orf161 SNXLQ969T32
Sorting nexin-25SNX25 MSTP043Q9H3E22
Sorting nexin-31SNX31Q8N9S92
Sorting nexin-32 (Sorting nexin-6B)SNX32 SNX6BQ86XE02
Sorting nexin-8SNX8Q9Y5X22
Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)SNX9 SH3PX1 SH3PXD3AQ9Y5X12
Spastin (EC 3.6.4.3)SPAST SPG4 hCG_23080E5KRP52
Spastin (EC 3.6.4.3) (Spastic paraplegia 4 protein)SPAST ADPSP FSP2 KIAA1083 SPG4Q9UBP02
Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52)TUT1 RBM21Q9H6E52
Spectrin beta chain, erythrocytic (Beta-I spectrin)SPTB SPTB1P112772
Sperm acrosome membrane-associated protein 6 (BACHELOR-like protein)SPACA6 SPACA6P UNQ2487/PRO5774W5XKT82
Sperm acrosome-associated protein 5 (EC 3.2.1.17) (Lysozyme-like protein 5) (Sperm-specific lysozyme-like protein X) (SLLP-X)SPACA5 LYZL5 SPACA5A UNQ6288/PRO20753; SPACA5BQ96QH82
Sperm flagellar protein 2 (Protein KPL2)SPEF2 KIAA1770 KPL2Q9C0932
Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1)SPAG1Q076172
Sperm-associated antigen 4 protein (Outer dense fiber-associated protein SPAG4) (SUN domain-containing protein 4)SPAG4 SUN4Q9NPE62
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)SPAG5Q96R062
Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84)SPAG8Q999322
Spermatid-associated protein (Protein chibby homolog 2)SPERT CBY2Q8NA612
Spermatogenesis-associated protein 16 (Testis development protein NYD-SP12)SPATA16Q9BXB72
Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)SPATA22Q8NHS92
Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3)SPATA7 HSD3Q9P0W82
Spermatogenesis-associated protein 8 (Spermatogenesis-related protein 8)SPATA8Q6RVD62
Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase)SMPD1 ASMP174052
Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)SPHK2Q9NRA02
Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (hSPP2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2)SGPP2Q8IWX52
Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)SF3A2 SAP62Q154282
Splicing factor arginine/serine-rich 3 (Splicing factor, arginine/serine-rich 3, isoform CRA_d) (cDNA, FLJ92926, Homo sapiens splicing factor, arginine/serine-rich 3 (SFRS3), mRNA)SFRS3 hCG_14802B2R6F32
Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)SFSWAP SFRS8 SWAPQ128722
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)SPRED1Q7Z6992
SR rich protein (Fragment)0Q8TEZ92
Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)SKAP1 SCAP1 SKAP55Q86WV12
Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP)STC2O760612
StAR protein binding protein (StAR protein binding protein 1b)SBP 1b SBPQ769H02
StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)STARD13 DLC2 GT650Q9Y3M82
StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3)STARD3 CAB1 MLN64Q148492
StatherinSTATHP028082
STEAP family member 1BSTEAP1BQ6NZ632
Sterile alpha motif domain-containing protein 3 (SAM domain-containing protein 3)SAMD3Q8N6K72
Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP)SRA1 PP7684Q9HD152
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2]SREBF2 BHLHD2 SREBP2Q127722
Striatin-interacting protein 2 (Protein FAM40B)STRIP2 FAM40B KIAA1170Q9ULQ02
Stromal cell-derived factor 2 (SDF-2)SDF2Q994702
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)SLX4 BTBD12 KIAA1784 KIAA1987Q8IY922
Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)ALDH5A1 SSADHP516492
Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1)QSOX2 QSCN6L1 SOXNQ6ZRP72
Sulfide:quinone oxidoreductase, mitochondrial (EC 1.-.-.-)SQRDL CGI-44Q9Y6N52
Sulfiredoxin-1 (EC 1.8.98.2)SRXN1 C20orf139 SRXQ9BYN02
Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2)SULT1A2 STP2P502262
Sulfotransferase 1A3 (ST1A3) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase 1A3/1A4) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST)SULT1A3 STMP0DMM92
SUMO-interacting motif-containing protein 1SIMC1 C5orf25Q8NDZ22
SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1)SUN1 KIAA0810 UNC84AO949012
Suppression of tumorigenicity 18 protein (Zinc finger protein 387)ST18 KIAA0535 ZNF387O602842
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)SOCS6 CIS4 SOCS4O145442
Surfeit locus protein 10E5KRX52
Surfeit locus protein 2 (Surf-2)SURF2Q155272
Surfeit locus protein 6SURF6 SURF-6O756832
Survival motor neuron protein (Component of gems 1) (Gemin-1)SMN1 SMN SMNT; SMN2 SMNCQ166372
Sushi domain-containing protein 1SUSD1 UNQ2438/PRO4999Q6UWL22
Sushi repeat-containing protein SRPXSRPX ETX1P785392
Synapsin-1 (Brain protein 4.1) (Synapsin I)SYN1P176002
Synaptogyrin-2 (Cellugyrin)SYNGR2 UNQ352/PRO615O437602
Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)SYNJ2 KIAA0348O150562
Synaptophysin-like 1, isoform CRA_b (Synaptophysin-like protein)SYPL SYPL1 hCG_16932 tcag7.98A4D0R22
Synaptopodin-2 (Genethonin-2) (Myopodin)SYNPO2Q9UMS62
Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29)SNAP29O957212
Synaptosomal-associated protein 47 (SNAP-47) (Epididymis luminal protein 170) (Synaptosomal-associated 47 kDa protein)SNAP47 C1orf142 HEL170 SVAP1Q5SQN12
Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII)SYT8Q8NBV82
Synaptotagmin-9 (Synaptotagmin IX) (SytIX)SYT9Q86SS62
Synaptotagmin-like protein 3 (Exophilin-6)SYTL3 SLP3Q4VX762
Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)SYTL4Q96C242
SyncytinERVWE1D0EYG52
Syntaxin-18 (Cell growth-inhibiting gene 9 protein)STX18 GIG9Q9P2W92
Syntaxin-19STX19Q8N4C72
Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B)STXBP2 UNC18BQ158332
Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)STXBP4Q6ZWJ12
Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1)STXBP5 LLGL3Q5T5C02
Syntaxin-binding protein 6 (Amisyn)STXBP6 HSPC156Q8NFX72
T-box transcription factor TBX5 (T-box protein 5)TBX5Q995932
T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)TAGAP TAGAP1 FKSG15Q8N1032
T-cell leukemia translocation-altered gene protein (T-cell leukemia translocation-associated gene protein)TCTAP577382
T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)TCL1A TCL1P562792
T-cell surface protein tactile (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD antigen CD96)CD96P402002
T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303)CCT6BQ925262
Tachykinin-4 (Preprotachykinin-C) (PPT-C) [Cleaved into: Endokinin-A (EKA); Endokinin-A/B (EKA/B); Endokinin-C (EKC)]TAC4Q86UU92
Tafazzin (Protein G4.5)TAZ EFE2 G4.5Q166352
Target of Myb protein 1TOM1O607842
Taste receptor type 1 member 1 (G-protein coupled receptor 70)TAS1R1 GPR70 T1R1 TR1 GM148Q7RTX12
Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2)TAS1R2 GPR71 T1R2 TR2Q8TE232
Taste receptor type 2 member 13 (T2R13) (Taste receptor family B member 3) (TRB3)TAS2R13Q9NYV92
Taste receptor type 2 member 40 (T2R40) (G-protein coupled receptor 60) (Taste receptor type 2 member 58) (T2R58)TAS2R40 GPR60P595352
Taste receptor type 2 member 50 (T2R50) (Taste receptor type 2 member 51) (T2R51)TAS2R50P595442
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)TBP GTF2D1 TF2D TFIIDP202262
Tau-tubulin kinase 2 (EC 2.7.11.1)TTBK2 KIAA0847Q6IQ552
TBC domain-containing protein kinase-like proteinTBCK TBCKL HSPC302Q8TEA72
TBC1 domain family member 13TBC1D13Q9NVG82
TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)TBC1D2 PARIS1 PP8997 TBC1D2AQ9BYX22
TBC1 domain family member 31 (WD repeat-containing protein 67)TBC1D31 WDR67Q96DN52
TBC1 domain family member 9 (TBC1 domain family member 9A)TBC1D9 KIAA0882 TBC1D9AQ6ZT072
TBC1 domain family, member 22B (TBC1 domain family, member 22B, isoform CRA_a) (cDNA FLJ77294, highly similar to Homo sapiens TBC1 domain family, member 22B (TBC1D22B), mRNA)TBC1D22B hCG_2003601A8KA282
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