EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)DOK5 C20orf180Q9P1041
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog)STT3B SIMPQ8TCJ21
Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]DBHP091721
Double homeobox protein 1DUX1O438121
Double homeobox protein ADUXAA6NLW81
Double-stranded RNA-binding protein Staufen homolog 2STAU2Q9NUL31
Doublesex- and mab-3-related transcription factor 3DMRT3 DMRTA3Q9NQL91
Down syndrome cell adhesion molecule-like protein 1 (Down syndrome cell adhesion molecule 2)DSCAML1 DSCAM2 KIAA1132Q8TD841
Down syndrome critical region gene 1-like 2, isoform CRA_b (Regulator of calcineurin 3 isoform 1a,2,3,4,5) (Regulator of calcineurin 3 isoform 1b,2,3,4,5) (Regulator of calcineurin 3 isoform 1c,2,3,4,5)RCAN3 DSCR1L2 hCG_19368E5L4P01
Down-regulator of transcription 1, TBP-binding (Negative cofactor 2), isoform CRA_a (Putative uncharacterized protein DKFZp666G145) (cDNA FLJ32979 fis, clone TESTI2017775, highly similar to TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN)DKFZp666G145 DR1 hCG_31940Q658N31
DPY30 domain-containing protein 1DYDC1 DPY30D1 RSD-9 RSD9Q8WWB31
dTDP-D-glucose 4,6-dehydratase (EC 4.2.1.46)TGDSO954551
DTGCU2DTGCU2Q54A151
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A)PDE11AQ9HCR91
Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)DUSP10 MKP5Q9Y6W61
Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1)DUSP12Q9UNI61
Dual specificity protein phosphatase 21 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 21) (LMW-DSP21)DUSP21 LMWDSP21Q9H5961
Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)DUSP7 PYST2Q168291
Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)DUSP9 MKP4Q999561
DUSP14 protein (Dual specificity phosphatase 14, isoform CRA_a) (cDNA, FLJ95796, Homo sapiens dual specificity phosphatase 14 (DUSP14), mRNA)DUSP14 hCG_28185Q6FI361
Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)DCTN4Q9UJW01
Dynamin-binding protein (Scaffold protein Tuba)DNMBP KIAA1010Q6XZF71
Dynamin-like 120 kDa protein, mitochondrial (Mitochondrial dynamin-like 120 kDa protein) (Optic atrophy 1 (Autosomal dominant), isoform CRA_g)OPA1 hCG_17270E5KLJ51
Dynein heavy chain 10, axonemal (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)DNAH10 KIAA2017Q8IVF41
Dynein heavy chain 11, axonemal (Axonemal beta dynein heavy chain 11) (Ciliary dynein heavy chain 11)DNAH11Q96DT51
Dynein heavy chain 12, axonemal (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein heavy chain 7-like, axonemal) (Dynein heavy chain domain-containing protein 2)DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19Q6ZR081
Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)DNAH14 C1orf67Q0VDD81
Dynein intermediate chain 2, axonemal (Axonemal dynein intermediate chain 2)DNAI2Q9GZS01
Dynein, light chain, Tctex-type 3 (TCTE1L protein) (cDNA, FLJ92116, Homo sapiens t-complex-associated-testis-expressed 1-like (TCTE1L),mRNA) (Fragment)TCTE1L DYNLT3 hCG_1986899Q6ICS31
Dysbindin domain-containing protein 2 (Casein kinase-1 binding protein) (CK1BP) (HSMNP1)DBNDD2 C20orf35Q9BQY91
Dyslexia-associated protein KIAA0319KIAA0319Q5VV431
Dystrophin-related protein 2 (DRP-2)DRP2Q134741
E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1)HACE1 KIAA1320Q8IYU21
E3 ubiquitin-protein ligase HECW2 (EC 6.3.2.-) (HECT, C2 and WW domain-containing protein 2) (NEDD4-like E3 ubiquitin-protein ligase 2)HECW2 KIAA1301 NEDL2Q9P2P51
E3 ubiquitin-protein ligase LNX (EC 6.3.2.-) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2)LNX1 LNX PDZRN2 UNQ574/PRO1136Q8TBB11
E3 ubiquitin-protein ligase MARCH5 (EC 6.3.2.-) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153)MARCH5 RNF153Q9NX471
E3 ubiquitin-protein ligase MARCH9 (EC 6.3.2.-) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179)MARCH9 RNF179Q86YJ51
E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Cell proliferation-inducing gene 53 protein) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)NEDD4 KIAA0093 NEDD4-1 PIG53P469341
E3 ubiquitin-protein ligase NEURL3 (EC 2.3.2.27) (Lung-inducible neuralized-related C3CH4 RING domain protein) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL3)NEURL3 LINCRQ96EH81
E3 ubiquitin-protein ligase RNF128 (EC 6.3.2.-) (Gene related to anergy in lymphocytes protein) (RING finger protein 128)RNF128 GRAILQ8TEB71
E3 ubiquitin-protein ligase RNF130 (EC 6.3.2.-) (Goliath homolog) (H-Goliath) (RING finger protein 130)RNF130Q86XS81
E3 ubiquitin-protein ligase RNF139 (EC 6.3.2.-) (RING finger protein 139) (Translocation in renal carcinoma on chromosome 8 protein)RNF139 TRC8Q8WU171
E3 ubiquitin-protein ligase RNF146 (EC 6.3.2.-) (Dactylidin) (Iduna) (RING finger protein 146)RNF146Q9NTX71
E3 ubiquitin-protein ligase RNF152 (EC 6.3.2.-) (RING finger protein 152)RNF152Q8N8N01
E3 ubiquitin-protein ligase RNF19B (EC 6.3.2.-) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)RNF19B IBRDC3 NKLAMQ6ZMZ01
E3 ubiquitin-protein ligase RNF213 (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213)RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTRQ63HN81
E3 ubiquitin-protein ligase RNF216 (EC 6.3.2.-) (RING finger protein 216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)RNF216 TRIAD3 UBCE7IP1 ZINQ9NWF91
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)SMURF2Q9HAU41
E3 ubiquitin-protein ligase TRIM21 (EC 6.3.2.-) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)TRIM21 RNF81 RO52 SSA1P194741
E3 ubiquitin-protein ligase TRIM31 (EC 6.3.2.-) (Tripartite motif-containing protein 31)TRIM31 C6orf13 RNFQ9BZY91
E3 ubiquitin-protein ligase TRIM69 (EC 6.3.2.-) (RFP-like domain-containing protein trimless) (RING finger protein 36) (Tripartite motif-containing protein 69)TRIM69 RNF36 HSD-34 HSD34Q86WT61
E3 ubiquitin-protein ligase UBR1 (EC 6.3.2.-) (N-recognin-1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)UBR1Q8IWV71
E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)UBR2 C6orf133 KIAA0349Q8IWV81
E3 ubiquitin-protein ligase ZNRF2 (EC 6.3.2.-) (Protein Ells2) (RING finger protein 202) (Zinc/RING finger protein 2)ZNRF2 RNF202Q8NHG81
E74-like factor 5 (Ets domain transcription factor), isoform CRA_a (cDNA FLJ78106, highly similar to Homo sapiens E74-like factor 5 (ets domain transcription factor) (ELF5), transcript variant 2, mRNA) (cDNA FLJ90716 fis, clone PLACE1008549, highly similar to ETS-related transcription factor Elf-5) (cDNA, FLJ92906, Homo sapiens E74-like factor 5 (ets domain transcription factor)(ELF5), mRNA)ELF5 hCG_28585A8K4431
Early placenta insulin-like peptide (EPIL) (Insulin-like peptide 4) (Placentin) [Cleaved into: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain]INSL4Q146411
EBNA1 binding protein 2 (EBNA1 binding protein 2 variant) (EBNA1 binding protein 2, isoform CRA_a) (EBNA1BP2 protein)EBNA1BP2 hCG_2031782Q6IB291
Ecotropic viral integration site 5 variant (Fragment)0Q59FE71
Ecto-ADP-ribosyltransferase 3 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 3) (ARTC3) (Mono(ADP-ribosyl)transferase 3) (NAD(P)(+)--arginine ADP-ribosyltransferase 3)ART3 TMARTQ135081
Ecto-ADP-ribosyltransferase 5 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 5) (ARTC5) (Mono(ADP-ribosyl)transferase 5) (NAD(P)(+)--arginine ADP-ribosyltransferase 5)ART5 UNQ575/PRO1137Q96L151
Ectoderm-neural cortex protein 1 (ENC-1) (Kelch-like protein 37) (Nuclear matrix protein NRP/B) (p53-induced gene 10 protein)ENC1 KLHL37 NRPB PIG10O146821
Ectonucleoside triphosphate diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.-) (Lysosomal apyrase-like protein 1)ENTPD7 LALP1Q9NQZ71
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (EC 3.1.4.12) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase)ENPP7 UNQ3077/PRO9912Q6UWV61
EF-hand calcium-binding domain-containing protein 1EFCAB1Q9HAE31
EF-hand calcium-binding domain-containing protein 12EFCAB12 C3orf25Q6NXP01
EF-hand calcium-binding domain-containing protein 13EFCAB13 C17orf57Q8IY851
EF-hand calcium-binding domain-containing protein 5EFCAB5A4FU691
EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP)EFCAB6 DJBP KIAA1672Q5THR31
EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase)EOGT AER61 C3orf64 EOGT1Q5NDL21
Egf-like module containing, mucin-like, hormone receptor-like 2EMR2A0JNV71
EGF-like module-containing mucin-like hormone receptor-like 1 (EGF-like module receptor 1) (EMR1 hormone receptor)EMR1 TM7LN3Q142461
Egl nine homolog 3 (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)EGLN3Q9H6Z91
EGR4 proteinEGR4B7ZKU31
ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1)ELAVL2 HUBQ129261
ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD)ELAVL4 HUD PNEMP263781
Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)SLC4A4 NBC NBC1 NBCE1Q9Y6R11
ELL-associated factor 1EAF1Q96JC91
ELMO2 protein (Engulfment and cell motility protein 2)ELMO2Q7Z5G91
Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very-long-chain 3-oxoacyl-CoA synthase 1)ELOVL1 SSC1 CGI-88Q9BW601
Elongation of very long chain fatty acids protein 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL3) (Cold-inducible glycoprotein of 30 kDa) (ELOVL fatty acid elongase 3) (ELOVL FA elongase 3) (Very-long-chain 3-oxoacyl-CoA synthase 3)ELOVL3 CIG30Q9HB031
Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very-long-chain 3-oxoacyl-CoA synthase 7)ELOVL7A1L3X01
Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150)IKBKAP ELP1 IKAPO951631
EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)EMILIN1 EMIQ9Y6C21
EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10)EMILIN2Q9BXX01
Endogenous Bornavirus-like nucleoprotein 2 (Endogenous Borna-like N element-2) (EBLN-2)EBLN2 GK006Q6P2I71
Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1)NEIL1Q96FI41
Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2)NEIL2Q969S21
Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)NEIL3Q8TAT51
Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)ERAP2 LRAPQ6P1791
Endosialin (Tumor endothelial marker 1) (CD antigen CD248)CD248 CD164L1 TEM1Q9HCU01
Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a (cDNA FLJ12746 fis, clone NT2RP2000842, highly similar to Lysophosphatidic acid receptor Edg-2) (cDNA FLJ78319, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA)EDG2 hCG_27597Q5VZX01
Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL)LIPG UNQ387/PRO719Q9Y5X91
Endothelial zinc finger protein induced by tumor necrosis factor alpha (Zinc finger protein 71)ZNF71 EZFITQ9NQZ81
Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1]EDN1P053051
Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2)EDN2P208001
Envelope protein ENVV1envV1M9QQA51
Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]EPX EPER EPO EPPP116781
Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)CCL11 SCYA11P516711
EP300-interacting inhibitor of differentiation 2B (EID-2B) (EID-2-like inhibitor of differentiation 3) (EID-3)EID2B EID3Q96D981
EPB41L2 proteinEPB41L2I6L9B11
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