EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)RIT1 RIBB RIT ROC1Q929631
GTPase IMAP family member 2 (Immunity-associated protein 2) (hIMAP2)GIMAP2 IMAP2Q9UG221
GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT)GIMAP8 IAN9 IANTQ8ND711
GTPase RhebL1 (Ras homolog enriched in brain like-1 c) (RhebL1c) (Ras homolog enriched in brain-like protein 1) (Rheb-like protein 1) (Rheb2)RHEBL1Q8TAI71
GTPase-activating Rap/Ran-GAP domain-like protein 3GARNL3Q5VVW21
Guanine monphosphate synthetase, isoform CRA_b (cDNA FLJ75406, highly similar to Homo sapiens guanine monphosphate synthetase (GMPS), mRNA) (cDNA, FLJ79481, highly similar to GMP synthase (glutamine-hydrolyzing) (EC6.3.5.2))GMPS hCG_1811302A8K6391
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (cDNA, FLJ92547, Homo sapiens guanine nucleotide binding protein (G protein), alphainhibiting activity polypeptide 3 (GNAI3), mRNA)GNAI3 hCG_1997731Q5TZX11
Guanine nucleotide exchange factor VAV3 (VAV-3)VAV3Q9UKW41
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3GNG3 GNGT3P632151
Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type)GNALP384051
Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain)GNAT1 GNATRP114881
Guanine nucleotide-binding protein subunit gammaGNG11 hCG_19197 tcag7.247Q53Y011
Guanylate-binding protein 5 (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5)GBP5 UNQ2427/PRO4987Q96PP81
Guanylate-binding protein 7 (GTP-binding protein 7) (GBP-7) (Guanine nucleotide-binding protein 7) (Guanylate-binding protein 4-like)GBP7 GBP4LQ8N8V21
Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A)GUCA1A C6orf131 GCAP GCAP1 GUCA1P430801
Guanylyl cyclase-activating protein 3 (GCAP 3) (Guanylate cyclase activator 1C)GUCA1C GCAP3O958431
Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein)GIN1 TGIN1 ZH2C2Q9NXP71
H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4)CLCN4P517931
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)CLCN5 CLCK2P517951
H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1)NAF1Q96HR81
Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor)HELTA6NFD81
Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Class B basic helix-loop-helix protein 32) (bHLHb32) (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (hHRT2) (Protein gridlock homolog)HEY2 BHLHB32 CHF1 GRL HERP HERP1 HRT2Q9UBP51
Hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL) (Class B basic helix-loop-helix protein 33) (bHLHb33) (Hairy-related transcription factor 3) (HRT-3) (hHRT3)HEYL BHLHB33 HRT3Q9NQ871
Hamartin (Tuberous sclerosis 1)TSC1Q86WV81
Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein)USH1C AIE75Q9Y6N91
HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C)HAUS1 CCDC5 HEICQ96CS21
HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27)HAUS2 C15orf25 CEP27Q9NVX01
HCG1 protein (Zinc finger protein 165)ZNF165 hCG_31427Q53Z401
HCG1774561 (Oxoglutarate receptor 1) (cDNA FLJ16066 fis, clone TRACH2006387, highly similar to 2-oxoglutarate receptor 1) (cDNA, FLJ94273, Homo sapiens G protein-coupled receptor 80 (GPR80), mRNA)hCG_1774561B2R9861
HCG1795924 (Protein atonal homolog 7)ATOH7 hCG_1795924F1T0H41
HCG1991317, isoform CRA_b (TWEAK) (Tumor necrosis factor (Ligand) superfamily, member 12)TWEAK TNFSF12 hCG_1991317Q4ACW91
HCG1994066, isoform CRA_a (cDNA FLJ78125, highly similar to Homo sapiens putative nucleic acid binding protein RY-1 (RY1), mRNA) (cDNA, FLJ92318, Homo sapiens putative nucleic acid binding protein RY-1 (RY1),mRNA)hCG_1994066A8K5131
HCG2001997, isoform CRA_c (cDNA FLJ36929 fis, clone BRACE2005231, highly similar to Nicolin-1) (cDNA, FLJ93554, Homo sapiens nicolin 1 (NICN1), mRNA)hCG_2001997B2R7Q31
HCG2003451, isoform CRA_d (NOX5 variant lacking EF hands) (Fragment)NOX5 hCG_2003451A3QRJ01
HCG2039726, isoform CRA_c (UDP glycosyltransferase 1 family polypeptide A6)UGT1A6 hCG_2039726Q5DSZ81
HCG2044639, isoform CRA_b (Receptor for advanced glycosylation end-products) (cDNA, FLJ93677, Homo sapiens advanced glycosylation end product-specific receptor(AGER), transcript variant 1, mRNA)AGER hCG_2044639Q3L1S01
HCG20684, isoform CRA_ahCG_20684D3DXD91
HCG22695, isoform CRA_ahCG_22695D6W6011
HCG37164, isoform CRA_b (LysM, putative peptidoglycan-binding, domain containing 3) (cDNA FLJ75941)LYSMD3 hCG_37164A8K6131
HCG38579, isoform CRA_c (cDNA FLJ39751 fis, clone SMINT2017855)hCG_38579Q8N8A71
HCG42405, isoform CRA_a (Zinc finger protein 30)ZFP30 hCG_42405D3Y2A01
HCTP4 (TPX2, microtubule-associated, homolog (Xenopus laevis), isoform CRA_b) (cDNA, FLJ92922)HCTP4 TPX2 hCG_38821Q643R01
Headcase protein homolog (hHDC)HECA HDCQ9UBI91
Heart- and neural crest derivatives-expressed protein 2 (Class A basic helix-loop-helix protein 26) (bHLHa26) (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)HAND2 BHLHA26 DHANDP612961
HEAT repeat-containing protein 5BHEATR5B KIAA1414Q9P2D31
HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1)HEATR6 ABC1Q6AI081
Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom)HSPA1LP349311
Heat shock 70 kDa protein 12BHSPA12B C20orf60Q96MM61
Heat shock 70kDa protein 1A (Heat shock 70kDa protein 1B) (cDNA FLJ75127, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNA)HSPA1B HSPA1A hCG_1820593 hCG_43726A8K5I01
Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)HSF4Q9ULV51
Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like)HSFY1 HSF2L HSFY; HSFY2 HSF2L HSFYQ96LI61
Hedgehog-interacting protein (HHIP) (HIP)HHIP HIP UNQ5825/PRO19644Q96QV11
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)SRCAP KIAA0309Q6ZRS21
Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase)HPGDS GSTS PGDS PTGDS2O607601
HemK methyltransferase family member 1 (EC 2.1.1.-) (M.HsaHemKP)HEMK1 HEMKQ9Y5R41
Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein)HEMGN EDAG NDR PRO1037 PRO1620Q9BXL51
Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain)HBG2P698921
Heparan sulfate glucosamine 3-O-sulfotransferase 2 (EC 2.8.2.29) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2) (3-OST-2) (Heparan sulfate 3-O-sulfotransferase 2) (h3-OST-2)HS3ST2 3OST2 UNQ2442/PRO5004Q9Y2781
Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST-2) (EC 2.8.2.-)HS6ST2 PSEC0092Q96MM71
Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1)SERPIND1 HCF2P055461
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3)HAVCR2 TIM3 TIMD3Q8TDQ01
Hepatocellular carcinoma antigen gene 520, isoform CRA_b (cDNA FLJ77903) (cDNA, FLJ93539, Homo sapiens hepatocellular carcinoma antigen gene 520 (LOC63928),mRNA)LOC63928 hCG_23125A8K2I81
Hephaestin (EC 1.-.-.-)HEPH KIAA0698 UNQ2562/PRO6242Q9BQS71
Hermansky-Pudlak syndrome 4HPS4Q6P1K31
HERV-FRD_6p24.1 provirus ancestral Env polyprotein (Endogenous retrovirus group FRD member 1) (Envelope polyprotein) (HERV-FRD) (Syncytin-2) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]ERVFRD-1 ERVFRDE1 UNQ6191/PRO20218P605081
HERV-H LTR-associating protein 2 (Human endogenous retrovirus-H long terminal repeat-associating protein 2)HHLA2Q9UM441
HERV-H LTR-associating protein 3 (Human endogenous retrovirus-H long terminal repeat-associating protein 3)HHLA3Q9XRX51
Heterogeneous nuclear ribonucleoprotein C-like (LOC440563 protein)LOC440563B2RXH81
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial (EC 2.1.1.114) (2-polyprenyl-6-hydroxyphenyl methylase) (EC 2.1.1.222) (3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase) (DHHB-MT) (DHHB-MTase) (3-demethylubiquinone-10 3-methyltransferase) (EC 2.1.1.64) (Dihydroxyhexaprenylbenzoate methyltransferase)COQ3 UG0215E05Q9NZJ61
HGC6.3 proteinHGC6.3Q9UM081
HHIP-like protein 2HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779Q6UWX41
High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1)SLC31A1 COPT1 CTR1O154311
High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)MS4A2 APY FCER1B IGERQ013621
High affinity immunoglobulin gamma Fc receptor IB (IgG Fc receptor IB) (Fc-gamma RIB) (FcRIB) (hFcgammaRIB)FCGR1B IGFRBQ926371
Highly divergent homeoboxHDX CXorf43Q7Z3531
Hippocampus abundant transcript 1 protein (Putative tetracycline transporter-like protein)HIAT1Q96MC61
Histamine H1 receptor (H1R) (HH1R)HRH1P353671
Histidine ammonia-lyase (Histidase) (EC 4.3.1.3)HAL HISP423571
Histo-blood group ABO system transferase (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) [Cleaved into: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form]ABOP164421
Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)KAT8 MOF MYST1 PP7073Q9H7Z61
Histone H1oo (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1)H1FOO H1OO OSH1Q8IZA31
Histone H2A0B2R5B31
Histone H2A type 1-H (Histone H2A/s)HIST1H2AH HIST1H2AIQ96KK51
Histone H2B type 1-H (Histone H2B.j) (H2B/j)HIST1H2BH H2BFJQ930791
Histone H2B type 1-M (Histone H2B.e) (H2B/e)HIST1H2BM H2BFEQ998791
Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)PHF8 KIAA1111 ZNF422Q9UPP11
Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.43) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)ASH1L KIAA1420 KMT2HQ9NR481
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.43) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)WHSC1L1 NSD3 DC28Q9BZ951
Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)SUV39H1 KMT1A SUV39HO434631
HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)HLA-DQA1P019091
HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2)HLA-DQA2 HLA-DXAP019061
HLA class II histocompatibility antigen, DQ beta 1 chain (MHC class II antigen) (cDNA, FLJ79232, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain)HLA-DQB1Q5Y7D61
HLA class II histocompatibility antigen, DR beta 4 chain (MHC class II antigen DRB4)HLA-DRB4P137621
HLA-DMA protein (Fragment)HLA-DMAQ6ICR91
HLTF protein (Fragment)HLTFQ05BZ61
HNRPK protein (Heterogeneous nuclear ribonucleoprotein K isoform a) (Heterogeneous nuclear ribonucleoprotein K, isoform CRA_c) (cDNA FLJ77137, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein K (HNRPK), transcript variant 1, mRNA)HNRPK HNRNPK hCG_1985922Q6IBN11
Homeobox D1HOXD1Q96CA41
Homeobox protein cut-like 2 (Homeobox protein cux-2)CUX2 CUTL2 KIAA0293O145291
Homeobox protein DLX-2DLX2Q076871
Homeobox protein DLX-3DLX3O604791
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