EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Leucine-rich repeat-containing protein 73LRRC73 C6orf154Q5JTD71
Leucine-rich repeat-containing protein 8D (Leucine-rich repeat-containing protein 5)LRRC8D LRRC5 UNQ213/PRO239Q7L1W41
Leucine-rich repeat-containing protein FAM211AFAM211A C17orf76Q8NAA51
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)LRIG1 LIG1Q96JA11
Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)LIFRP427021
Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)LILRA2 ILT1 LIR7Q8N1491
Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)CD53 MOX44 TSPAN25P193971
Leukotriene-B(4) omega-hydroxylase 2 (EC 1.14.13.30) (CYPIVF3) (Cytochrome P450 4F3) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 2)CYP4F3 LTB4HQ084771
LGI4 proteinLGI4A5D6Y51
Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein)LCORLQ8N3X61
Ligand-dependent nuclear receptor-interacting factor 1 (Receptor-interacting factor 1)LRIF1 C1orf103 RIF1Q5T3J31
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)LDB1 CLIM2Q86U701
LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein)LDB3 KIAA0613 ZASPO751121
LIM/homeobox protein Lhx3 (LIM homeobox protein 3)LHX3Q9UBR41
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)LHX4Q969G21
LIM/homeobox protein Lhx5 (LIM homeobox protein 5)LHX5Q9H2C11
LIM/homeobox protein Lhx8 (LIM homeobox protein 8)LHX8Q68G741
LINE-1 type transposase domain-containing protein 1 (ES cell-associated protein 11)L1TD1 ECAT11Q5T7N21
Lipase maturation factor 1 (Transmembrane protein 112)LMF1 C16orf26 TMEM112 HMFN1876 JFP11Q96S061
Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153)LMF2 TMEM112B TMEM153Q9BU231
Lipid phosphate phosphatase-related protein type 4 (EC 3.1.3.4) (Brain-specific phosphatidic acid phosphatase-like protein 1) (Plasticity-related gene 1 protein) (PRG-1)LPPR4 KIAA0455 PRG1Q7Z2D51
Lipocalin-1 (Tear lipocalin) (Tlc) (Tear prealbumin) (TP) (Von Ebner gland protein) (VEG protein)LCN1 VEGPP310251
Lipoma HMGIC fusion partner-like 1 proteinLHFPL1 UNQ5824/PRO19643Q86WI01
Lipoma HMGIC fusion partner-like 2 proteinLHFPL2 KIAA0206Q6ZUX71
Lipoxygenase homology domain-containing protein 1LOXHD1F5GZB41
Lipoxygenase homology domain-containing protein 1LOXHD1Q8IVV21
Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)PPFIA2O753341
Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4)PPFIA4 KIAA0897O753351
Lithostathine-1-alpha (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (Regenerating islet-derived protein 1-alpha) (REG-1-alpha) (Regenerating protein I alpha)REG1A PSPS PSPS1 REGP054511
Liver X nuclear receptor alpha variant 1NR1H3F1D8N11
LIX1-like proteinLIX1LQ8IVB51
LOC136263LOC136263 hCG_1657059A4D1L01
LON peptidase N-terminal domain and RING finger protein 2 (Neuroblastoma apoptosis-related protease) (RING finger protein 192)LONRF2 RNF192Q1L5Z91
LON peptidase N-terminal domain and RING finger protein 3 (RING finger protein 127)LONRF3 RNF127Q496Y01
Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1)SLC27A6 ACSVL2 FACVL2 FATP1Q9Y2P41
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Bubblegum-related protein) (PRTD-NY3)ACSBG2 BGR UNQ2443/PRO5005Q5FVE41
Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]FCER2 CD23A CLEC4J FCE2 IGEBFP067341
Low affinity immunoglobulin gamma Fc region receptor III-AFCGR3AM9MML01
Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)FCGR3B CD16B FCG3 FCGR3 IGFR3O750151
Low-density lipoprotein receptor class A domain-containing protein 4LDLRAD4 C18orf1O151651
Low-density lipoprotein receptor-related protein 11 (LRP-11)LRP11Q86VZ41
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)LRP2P981641
Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)LRP4 KIAA0816 LRP10 MEGF7O750961
LP81650Q6XYB51
LRP2-binding protein (Megalin-binding protein) (MegBP)LRP2BP KIAA1325Q9P2M11
LRRTM4 protein (cDNA FLJ12568 fis, clone NT2RM4000857, weakly similar to LEUCINE-RICH ALPHA-2-GLYCOPROTEIN)LRRTM4Q9H9T01
LUZP1 protein (Fragment)LUZP1Q05DE31
Ly6/PLAUR domain-containing protein 8LYPD8 UNQ511/PRO1026Q6UX821
Lymphocyte activation gene 3 protein (LAG-3) (Protein FDC) (CD antigen CD223)LAG3 FDCP186271
Lymphocyte antigen 86 (Ly-86) (Protein MD-1)LY86 MD1O957111
Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58)CD58 LFA3P192561
Lymphotactin (ATAC) (C motif chemokine 1) (Cytokine SCM-1) (Lymphotaxin) (SCM-1-alpha) (Small-inducible cytokine C1) (XC chemokine ligand 1)XCL1 LTN SCYC1P479921
Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3)LTB TNFC TNFSF3Q066431
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)BRCC3 BRCC36 C6.1A CXorf53P467361
Lysine-specific demethylase 4A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A)KDM4A JHDM3A JMJD2 JMJD2A KIAA0677O751641
Lysine-specific demethylase 4C (EC 1.14.11.-) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C)KDM4C GASC1 JHDM3C JMJD2C KIAA0780Q9H3R01
Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5)KDM8 JMJD5Q8N3711
Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (Acyl-CoA:lysocardiolipin acyltransferase 1)LCLAT1 AGPAT8 ALCAT1 LYCAT UNQ1849/PRO3579Q6UWP71
Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4)LPAR2 EDG4 LPA2Q9HBW01
Lysophosphatidic acid receptor 4 (LPA receptor 4) (LPA-4) (G-protein coupled receptor 23) (P2Y purinoceptor 9) (P2Y9) (P2Y5-like receptor) (Purinergic receptor 9)LPAR4 GPR23 LPA4 P2RY9Q996771
Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)LPAR5 GPR92 GPR93Q9H1C01
Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3)LPCAT1 AYTL2 PFAAP3Q8NF371
Lysosomal associated multispanning membrane protein 5, isoform CRA_a (Lysosomal multispanning membrane protein 5) (cDNA FLJ75768, highly similar to Homo sapiens lysosomal associated multispanning membrane protein 5 (LAPTM5), mRNA)LAPTM5 hCG_15079Q5TBB81
Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)LAMP3 DCLAMP TSC403Q9UQV41
Lysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5)LAMP5 C20orf103Q9UJQ11
Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)LYZ LZMP616261
Lysozyme g-like protein 2 (EC 3.2.1.-)LYG2 LYGHQ86SG71
Lysozyme-like protein 2 (Lysozyme-2) (EC 3.2.1.17)LYZL2Q7Z4W21
Lysozyme-like protein 4 (Lysozyme-4)LYZL4 LYC4Q96KX01
Lysyl oxidase homolog 3 (EC 1.4.3.-) (Lysyl oxidase-like protein 3)LOXL3 LOXLP582151
m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)DCPS DCS1 HINT5 HSPC015Q96C861
Macoilin (Transmembrane protein 57)TMEM57Q8N5G21
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]MST1R PTK8 RONQ049121
Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A)MROH1 HEATR7A KIAA1833Q8NDA81
Maestro heat-like repeat-containing protein family member 7 (HEAT repeat-containing protein 8)MROH7 C1orf175 HEATR8Q68CQ11
Maestro heat-like repeat-containing protein family member 9MROH9 C1orf129Q5TGP61
MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)MPP2 DLG2Q141681
MAGUK p55 subfamily member 5MPP5Q8N3R91
MAGUK p55 subfamily member 7MPP7Q5T2T11
Major facilitator superfamily domain-containing protein 2BMFSD2BA6NFX11
Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7)MFSD8 CLN7Q8NHS31
Makorin, ring finger protein, 2, isoform CRA_b (Probable E3 ubiquitin-protein ligase makorin-2) (cDNA FLJ52346, highly similar to Makorin-2)MKRN2 hCG_28319B4DPR41
MAL-like protein (Protein BENE)MALL BENEQ130211
Malonyl CoA:ACP acyltransferase (Mitochondrial) (Malonyl-CoA:acyl carrier protein transacylase, mitochondrial, isoform CRA_a) (cDNA, FLJ94725, Homo sapiens malonyl-CoA:acyl carrier protein transacylase(malonyltransferase) (MT), mRNA)MCAT MT AL022237.1-002 hCG_41916B0QY721
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3)MDGA1 MAMDC3Q8NFP41
Mammaglobin-A (Mammaglobin-1) (Secretoglobin family 2A member 2)SCGB2A2 MGB1 UGB2Q132961
Mammaglobin-B (Lacryglobin) (Lipophilin-C) (Mammaglobin-2) (Secretoglobin family 2A member 1)SCGB2A1 LIPHC MGB2 UGB3O755561
MAN2A1 proteinMAN2A1Q49A691
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)MAN1A1P339081
MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein)MANSC1 LOH12CR3 UNQ316/PRO361Q9H8J51
MAP1A protein (Fragment)MAP1AQ504X91
MAP2 protein (Fragment)MAP2Q6NYC51
MAP3K12 binding inhibitory protein 1, isoform CRA_b (cDNA, FLJ96307, Homo sapiens MAP3K12 binding inhibitory protein 1 (MBIP), mRNA)MBIP hCG_20993B2RCV01
MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein)MBIP BM-015Q9NS731
Marginal zone B- and B1-cell-specific protein (Mesenteric estrogen-dependent adipose 7) (MEDA-7) (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein)MZB1 MEDA7 PACAP HSPC190Q8WU391
Mas-related G-protein coupled receptor member X3 (Sensory neuron-specific G-protein coupled receptor 1/2)MRGPRX3 MRGX3 SNSR1 SNSR2Q96LB01
Mast cell-expressed membrane protein 1MCEMP1 C19orf59Q8IX191
Mastermind-like protein 2 (Mam-2)MAML2 KIAA1819Q8IZL21
Mastermind-like protein 3 (Mam-3)MAML3 KIAA1816Q96JK91
Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase)MMP7 MPSL1 PUMP1P092371
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