EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)RYR3 HBRRQ154131
RYK protein (Fragment)RYKQ8WTZ81
S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Augmented in rheumatoid arthritis 1) (AURA1) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain-containing protein 1)OLAH THEDC1Q9NV231
S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)MAT1A AMS1 MATA1Q002661
S100P-binding protein (S100P-binding protein Riken)S100PBP S100PBPRQ96BU11
Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29)SACS KIAA0730Q9NZJ41
SaitohinSTHQ8IWL81
Salivary acidic proline-rich phosphoprotein 1/2 (Db-s) (PRP-1/PRP-2) (Parotid acidic protein) (Pa) (Parotid double-band protein) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) [Cleaved into: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (Db-F) (PIF-F) (PRP-3/PRP-4) (Protein A); Peptide P-C]PRH1; PRH2P028101
SALL3 proteinSALL3A9JR481
SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog)SASH3 CXorf9 SLYO759951
SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)SAMSN1 HACS1Q9NSI81
SAM-dependent methyltransferase (cDNA FLJ25072 fis, clone CBL05716)0Q969Z21
SAP30-binding protein (Transcriptional regulator protein HCNGP)SAP30BP HCNGP HTRG HTRPQ9UHR51
Sarcosine dehydrogenase, mitochondrial (SarDH) (EC 1.5.8.3) (BPR-2)SARDH DMGDHL1Q9UL121
SAT protein (Spermidine/spermine N1-acetyltransferase, isoform CRA_b) (cDNA, FLJ92448, Homo sapiens spermidine/spermine N1-acetyltransferase (SAT), mRNA) (Fragment)SAT hCG_17885Q6ICU91
SCAN-related protein RAZ1 (Fragment)RAZ1Q9NZG61
Scavenger receptor cysteine-rich domain-containing group B protein (S4-SRCRB)SRCRB4DQ8WTU21
Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]CD163 M130Q86VB71
Schlafen family member 12SLFN12Q8IYM21
Schlafen family member 13SLFN13Q68D061
Schlafen-like protein 1SLFNL1Q499Z31
SciellinSCELO951711
SclerostinSOST UNQ2976/PRO7455/PRO7476Q9BQB41
Sclerostin domain-containing protein 1 (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1)SOSTDC1 USAG1 CDA019Q6X4U41
Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2)SFMBT2 KIAA1617Q5VUG01
SCUBE1 proteinSCUBE1Q86TI61
SDS protein0Q8WW811
Secernin-3SCRN3Q0VDG41
SecretagoginSCGN SECRETO760381
Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)SFRP4 FRPHEQ6FHJ71
Secreted Ly-6/uPAR-related protein 1 (SLURP-1) (ARS component B) (ARS(component B)-81/S) (Anti-neoplastic urinary protein) (ANUP)SLURP1 ARSP550001
Secretoglobin family 1D member 1 (Lipophilin-A)SCGB1D1 LIPHA LPNAO959681
Securin-2 (Pituitary tumor-transforming gene 2 protein)PTTG2Q9NZH51
Selenoprotein K (SelK)SELK HSPC030 HSPC297Q9Y6D01
Selenoprotein P (SeP)SEPP1 SELPP499081
SELT protein (Selenoprotein T) (cDNA FLJ90525 fis, clone NT2RP4001001, highly similar to Selenoprotein T)SELT hCG_20913Q6IAK01
Semaphorin-3B (Sema A(V)) (Semaphorin-V) (Sema V)SEMA3B SEMA5 SEMAAQ132141
Semaphorin-4A (Semaphorin-B) (Sema B)SEMA4A SEMAB SEMB UNQ783/PRO1317Q9H3S11
Semaphorin-4BSEMA4BJ3KNP41
Semaphorin-4F (Semaphorin-M) (Sema M) (Semaphorin-W) (Sema W)SEMA4F SEMAM SEMAWO957541
Semaphorin-5A (Semaphorin-F) (Sema F)SEMA5A SEMAFQ135911
Semaphorin-6C (Semaphorin-Y) (Sema Y)SEMA6C KIAA1869 SEMAYQ9H3T21
Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)SEMA7A CD108 SEMALO753261
Semenogelin-2 (Semenogelin II) (SGII)SEMG2Q023831
Sentrin-specific protease 5 (EC 3.4.22.68) (Sentrin/SUMO-specific protease SENP5)SENP5 FKSG45Q96HI01
Sentrin-specific protease 7 (EC 3.4.22.68) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7)SENP7 KIAA1707 SSP2 SUSP2Q9BQF61
Seprase (EC 3.4.21.-) (170 kDa melanoma membrane-bound gelatinase) (Fibroblast activation protein alpha) (Integral membrane serine protease)FAPQ128841
Septin 6 (Septin 6, isoform CRA_d) (cDNA FLJ58747, highly similar to Septin-6)SEPT6 hCG_23191Q541S41
Septin-1241529Q8IYM11
Septin-8SEPT8 KIAA0202Q925991
SERINC2 protein (Fragment)SERINC2Q96IM81
Serine incorporator 5SERINC5 C5orf12Q86VE91
Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb)SPTSSB ADMP C3orf57 SSSPTBQ8NFR31
Serine protease 23 (EC 3.4.21.-) (Putative secreted protein Zsig13)PRSS23 ZSIG13 UNQ270/PRO307O950841
Serine protease 38 (EC 3.4.21.-) (Marapsin-2)PRSS38 MPN2A1L4531
Serine protease 42 (EC 3.4.21.-) (Testis serine protease 2)PRSS42 TESSP2Q7Z5A41
Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II)SPINK2P201551
Serine racemase (EC 4.3.1.17) (EC 4.3.1.18) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (L-serine ammonia-lyase) (L-serine dehydratase)SRRQ9GZT41
Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100)SRRM4 KIAA1853A7MD481
Serine/threonine kinase 24 (STE20 homolog, yeast)STK24Q6P0Y11
Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine-protein kinase NYD-SPK) (Sugen kinase 396) (SgK396)STK31 SGK396Q9BXU11
Serine/threonine-protein kinase 32A (EC 2.7.11.1) (Yet another novel kinase 1)STK32A YANK1Q8WU081
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)CHEK2 CDS1 CHK2 RAD53O960171
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)MARK2 EMK1Q7KZI71
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)NEK4 STK2P519571
Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)NEK9 KIAA1995 NEK8 NERCCQ8TD191
Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)PAK7 KIAA1264 PAK5Q9P2861
Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like)PDIK1L CLIK1LQ8N1651
Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h)PIM2Q9P1W91
Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase)PLK2 SNKQ9NYY31
Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)PLK3 CNK FNK PRKQ9H4B41
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)PLK4 SAK STK18O004441
Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1)RIOK1Q9BRS21
Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2)SGK2Q9HBY81
Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)SIK2 KIAA0781 QIK SNF1LK2Q9H0K11
Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)TNNI3K CARKQ59H181
Serine/threonine-protein kinase WNK2WNK2F8W9F91
Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]ERN2 IRE2Q76MJ51
Serine/threonine-protein phosphatase (EC 3.1.3.16)PPP2CA hCG_16586B3KUN11
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55-gamma) (PP2A subunit B isoform PR55-gamma) (PP2A subunit B isoform R2-gamma) (PP2A subunit B isoform gamma)PPP2R2CQ9Y2T41
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)PPP5C PPP5P530411
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52)ANKRD52Q8NB461
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)TF PRO1400P027871
Serpin A11SERPINA11Q86U171
Serpin A12 (OL-64) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (Visceral adipose-specific serpin)SERPINA12Q8IW751
Serpin B10 (Bomapin) (Peptidase inhibitor 10) (PI-10)SERPINB10 PI10P485951
Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2)SERPINB4 PI11 SCCA2P485941
Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8)SERPINB8 PI8P504521
Serpin I2 (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Pancreas-specific protein TSA2004) (Peptidase inhibitor 14) (PI-14)SERPINI2 MEPI PI14O758301
SERTA domain containing 1 variant (SERTA domain containing 1, isoform CRA_a) (cDNA FLJ90171 fis, clone MAMMA1000403, highly similar to SERTA domain-containing protein 1) (Fragment)SERTAD1 hCG_1777718Q53GC01
Serum amyloid A-1 protein (SAA) [Cleaved into: Amyloid protein A (Amyloid fibril protein AA); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(2-103); Serum amyloid protein A(2-102); Serum amyloid protein A(4-101)]SAA1P0DJI81
Serum deprivation-response protein (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein)SDPRO958101
Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)PON1 PONP271691
Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP)SRFBP1Q8NEF91
Sesquipedalian-2 (Ses2) (27 kDa inositol polyphosphate phosphatase interacting protein B) (IPIP27B)FAM109BQ6ICB41
Sestrin-2 (Hi95)SESN2 SEST2P580041
Sestrin-3SESN3 SEST3P580051
SET (SET translocation (Myeloid leukemia-associated), isoform CRA_a) (cDNA FLJ51749, highly similar to Protein SET)SET hCG_40357Q5VXV31
SET and MYND domain-containing protein 5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15)SMYD5 RAI15Q6GMV21
Seven in absentia homolog 3 (Siah-3)SIAH3Q8IW031
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