EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)SLC22A6 OAT1 PAHTQ4U2R81
Solute carrier family 22 member 7 (Novel liver transporter) (Organic anion transporter 2) (hOAT2)SLC22A7 NLT OAT2Q9Y6941
Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)SLC23A2 KIAA0238 NBTL1 SLC23A1 SVCT2 YSPL2Q9UGH31
Solute carrier family 23 member 3 (HPC E2-binding protein 3) (Na(+)/L-ascorbic acid transporter 3) (Sodium-dependent vitamin C transporter 3)SLC23A3 E2BP3 SVCT3Q6PIS11
Solute carrier family 25 member 35SLC25A35Q3KQZ11
Solute carrier family 25 member 40 (Mitochondrial carrier family protein)SLC25A40 MCFPQ8TBP61
Solute carrier family 25 member 41SLC25A41Q8N5S11
Solute carrier family 25 member 53 (Mitochondrial carrier triple repeat protein 6)SLC25A53 MCART6Q5H9E41
Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)SLC26A6Q9BXS91
Solute carrier family 35 member E2BSLC35E2B KIAA0447P0CK961
Solute carrier family 35 member G1 (Transmembrane protein 20)SLC35G1 C10orf60 TMEM20Q2M3R51
Solute carrier family 35 member G2 (Transmembrane protein 22)SLC35G2 TMEM22Q8TBE71
Solute carrier family 35, member C1, isoform CRA_b (cDNA FLJ33926 fis, clone CTONG2017409, highly similar to GDP-fucose transporter 1) (cDNA FLJ90448 fis, clone NT2RP3001271, highly similar to GDP-fucose transporter 1)SLC35C1 hCG_1785265B3KQH01
Solute carrier family 41 member 2SLC41A2Q96JW41
Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3)SLC52A2 GPR172A PAR1 RFT3Q9HAB31
Solute carrier family 7 member 13 (Sodium-independent aspartate/glutamate transporter 1) (X-amino acid transporter 2)SLC7A13 AGT1 XAT2Q8TCU31
Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Solute carrier family 21 member 9)SLCO2B1 KIAA0880 OATP2B1 OATPB SLC21A9O949561
Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12)SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12Q96BD01
Sonic hedgehog protein (SHH) (HHG-1) [Cleaved into: Sonic hedgehog protein N-product; Sonic hedgehog protein C-product]SHHQ154651
Sorting nexin 12 (Sorting nexin 12, isoform CRA_a) (cDNA, FLJ93438, Homo sapiens sorting nexin 12 (SNX12), mRNA)SNX12 hCG_1990496Q3SYF11
Sorting nexin 13SNX13Q86XC41
Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)SNX13 KIAA0713Q9Y5W81
Sorting nexin-16SNX16P577681
Sorting nexin-29 (RUN domain-containing protein 2A)SNX29 RUNDC2AQ8TEQ01
SP3 protein (Fragment)SP3Q86TP01
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)SPTBN2 KIAA0302 SCA5O150201
Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)SPTBN4 KIAA1642 SPTBN3Q9H2541
Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)SPDYA SPDY1 SPY1Q5MJ701
Speriolin (Spermatogenesis and centriole-associated protein 1) (Spermatogenesis-associated protein 15) (Spermatogenic cell-specific Cdc20-binding protein)SPATC1 SPATA15 SPRNQ76KD61
Sperm protamine P1P1 PRM1 hCG_15067Q3MN801
Sperm protein associated with the nucleus on the X chromosome N2 (Nuclear-associated protein SPAN-Xn2) (SPANX-N2) (SPANX family member N2)SPANXN2Q5MJ101
Sperm-associated antigen 11B (Human epididymis-specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2)SPAG11B EP2 HE2Q086481
Spermatid-specific manchette-related protein 1 (Ciliated bronchial epithelial protein 1) (Testis development protein NYD-SP22)SMRP1 C9orf24 CBE1Q8NCR61
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1SOHLH1 C9orf157 NOHLH TEB2Q5JUK21
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2SOHLH2 TEB1Q9NX451
Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)SPATA13Q96N961
Spermatogenesis-associated protein 17SPATA17Q96L031
Spermatogenesis-associated protein 25 (Testis-specific gene 23 protein)SPATA25 C20orf165 TSG23Q9BR101
Spermatogenesis-associated protein 3 (Testis and spermatogenesis cell-related protein 1) (Testis spermatocyte apoptosis-related protein 1)SPATA3 TSARG1Q8NHX41
Spermatogenesis-associated protein 5-like protein 1SPATA5L1Q9BVQ71
Spermatogenesis-associated protein 6SPATA6Q9NWH71
Spermatogenesis-associated serine-rich protein 1SPATS1Q496A31
Spermidine/spermine N(1)-acetyltransferase-like protein 1 (EC 2.3.1.-)SATL1Q86VE31
Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase)SMPD2O609061
Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)SMPD4 KIAA1418Q9NXE41
Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3)S1PR3 EDG3Q995001
Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91)SPHK1 SPHK SPKQ9NYA11
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)SGPL1 KIAA1252O954701
Spindle and kinetochore-associated protein 1SKA1 C18orf24Q96BD81
Spindle and kinetochore-associated protein 3SKA3 C13orf3 RAMA1Q8IX901
Spindle assembly abnormal protein 6 homolog (HsSAS-6)SASS6 SAS6Q6UVJ01
Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A)SPIN2A DXF34 SPIN2Q998651
Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B)SPIN2B SPIN2Q9BPZ21
Splicing factor 3A subunit 1SF3A1E9PAW11
Splicing factor proline/glutamine-rich (Polypyrimidine tract binding protein associated)SFPQQ86VG21
Splicing factor, arginine/serine-rich 1 (Splicing factor 2, alternate splicing factor) variant (Fragment)0Q59FA21
Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4) (SR-related and CTD-associated factor 4)SCAF4 KIAA1172 SFRS15O951041
SPOC domain-containing protein 1SPOCD1Q6ZMY31
Spondin-2 (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1) (Mindin)SPON2 DIL1 UNQ435/PRO866Q9BUD61
SprT-like domain-containing protein Spartan (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan)SPRTN C1orf124 DVC1 UNQ1880/PRO4323Q9H0401
SPRY domain-containing SOCS box protein 1 (SSB-1)SPSB1 SSB1Q96BD61
SPRY domain-containing SOCS box protein 4 (SSB-4)SPSB4 SSB4Q96A441
SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)SRCIN1 KIAA1684 P140Q9C0H91
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)SRPK3 MSSK1 STK23Q9UPE11
STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like)SUPT7L KIAA0764O948641
StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3)STARD8 DLC3 KIAA0189Q925021
Starch-binding domain-containing protein 1 (Genethonin-1)STBD1 GENX-3414O952101
Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)STMN2 SCG10 SCGN10Q930451
Stathmin-3 (SCG10-like protein)STMN3 SCLIPQ9NZ721
Stem-loop (Histone) binding protein (Stem-loop (Histone) binding protein, isoform CRA_b) (cDNA, FLJ96722, Homo sapiens stem-loop (histone) binding protein (SLBP), mRNA)SLBP hCG_19671Q53XR21
Sterile alpha motif domain-containing protein 12 (SAM domain-containing protein 12)SAMD12Q8N8I01
Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14)SAMD14Q8IZD01
Sterol 26-hydroxylase, mitochondrial (EC 1.14.13.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)CYP27A1 CYP27Q023181
Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STATP356101
Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like (Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like variant) (Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like, isoform CRA_b) (cDNA, FLJ93018, highly similar to Homo sapiens sterol-C5-desaturase (ERG3 delta-5-desaturase homolog,fungal)-like (SC5DL), mRNA)SC5DL hCG_1641241Q6GTM51
Stimulated by retinoic acid gene 6 protein homologSTRA6 PP14296 UNQ3126/PRO10282/PRO19578Q9BX791
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)TMEM173 ERIS MITA STINGQ86WV61
Stomatin-like protein 3 (SLP-3)STOML3Q8TAV41
Stonin-2 (Stoned B)STON2 STN2 STNBQ8WXE91
Storkhead-box protein 1 (Winged-helix domain-containing protein)STOX1 C10orf24Q6ZVD71
Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)MMP3 STMY1P082541
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1)SMCHD1 KIAA0650A6NHR91
Submaxillary gland androgen-regulated protein 3B (Proline-rich peptide P-B) (Proline-rich protein 3) [Cleaved into: Peptide P-A; Peptide D1A]SMR3B PBII PRL3 PROL3P028141
Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)TACR2 NK2R NKNAR TAC2RP214521
Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)TACR1 NK1R TAC1RP251031
Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like)SUCNR1 GPR91Q9BXA51
Sulfatase-modifying factor 1 (EC 1.8.99.-) (C-alpha-formylglycine-generating enzyme 1)SUMF1 FGE PSEC0152 UNQ3037/PRO9852Q8NBK31
Sulfotransferase 1A3/1A4 (ST1A3/ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST)SULT1A3 STM; SULT1A4P502241
Sulfotransferase 6B1 (ST6B1) (Thyroxine sulfotransferase) (EC 2.8.2.n2)SULT6B1Q6IMI41
SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1)USPL1 C13orf22 D13S106Q5W0Q71
SUN domain-containing protein 3 (Sad1/unc-84 domain-containing protein 1)SUN3 SUNC1Q8TAQ91
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)SOCS1 SSI1 TIP3O155241
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)SOCS3 CIS3 SSI3O145431
Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)SOCS7 NAP4 SOCS6O145121
Suppressor of fused homolog (SUFUH)SUFU UNQ650/PRO1280Q9UMX11
Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)ST14 PRSS14 SNC19 TADG15Q9Y5Y61
Suppressor of tumorigenicity 7 protein-like (ST7-related protein)ST7L ST7RQ8TDW41
SuprabasinSBSN UNQ698/PRO1343Q6UWP81
Sushi domain-containing protein 4SUSD4 UNQ196/PRO222Q5VX711
Sushi repeat-containing protein SRPX2SRPX2 SRPULO606871
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