EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Cathepsin S (EC 3.4.22.27)CTSSP257746
CBX1 protein (Chromobox homolog 1 (HP1 beta homolog Drosophila ), isoform CRA_a) (cDNA, FLJ92997, Homo sapiens chromobox homolog 1 (HP1 beta homolog Drosophila ) (CBX1), mRNA)CBX1 hCG_2000655Q6IBN66
CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)CNOT3 KIAA0691 LENG2 NOT3O751756
CD69 antigen (CD69 antigen (P60, early T-cell activation antigen), isoform CRA_a) (cDNA FLJ75888, highly similar to Homo sapiens CD69 antigen (p60, early T-cell activation antigen) (CD69), mRNA)CD69 hCG_38142Q53ZX06
CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)CD99 MIC2 MIC2X MIC2YP142096
Cdc42 effector protein 4 (Binder of Rho GTPases 4)CDC42EP4 BORG4 CEP4Q9H3Q16
CDGSH iron-sulfur domain-containing protein 1 (MitoNEET)CISD1 C10orf70 ZCD1 MDS029Q9NZ456
CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)CDK5RAP2 CEP215 KIAA1633Q96SN86
CDKN2AIP N-terminal-like protein (CDKN2A-interacting protein N-terminal-like protein)CDKN2AIPNLQ96HQ26
cDNA FLJ772190A8KAG16
Cell cycle checkpoint protein RAD1 (hRAD1) (EC 3.1.11.2) (DNA repair exonuclease rad1 homolog) (Rad1-like DNA damage checkpoint protein)RAD1 REC1O606716
Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)RAD17 R24LO759436
Cell division cycle-associated protein 7 (Protein JPO1)CDCA7 JPO1Q9BWT16
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)MCAM MUC18P431216
Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)CRABP2P293736
Centrosomal protein of 104 kDa (Cep104)CEP104 KIAA0562O603086
Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4)CEP135 CEP4 KIAA0635Q66GS96
Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin)CEP57 KIAA0092 TSP57Q86XR86
Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4)CERK KIAA1646Q8TCT06
Cerebellar degeneration-related protein 2 (Major Yo paraneoplastic antigen) (Paraneoplastic cerebellar degeneration-associated antigen)CDR2 PCD17Q018506
Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2Q9NZZ36
Chemokine-like factor (C32)CKLF CKLF1 HSPC224 UNQ410/PRO772Q9UBR56
Chondrosarcoma-associated gene 2/3 protein (Cancer/testis antigen 24.2) (CT24.2) (Taxol-resistant-associated gene 3 protein) (TRAG-3)CSAG2 TRAG3; CSAG3 CSAG3AQ9Y5P26
Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2)CHD2O146476
Coiled-coil domain-containing protein 132CCDC132 KIAA1861Q96JG66
Coiled-coil domain-containing protein 167CCDC167 C6orf129 HSPC265Q9P0B66
Coiled-coil domain-containing protein 58CCDC58Q4VC316
Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)CCDC6 D10S170 TST1Q162046
Coiled-coil domain-containing protein 82CCDC82 HT025Q8N4S06
Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain)CCDC86 CYCLONQ9H6F56
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5CHCHD5 C2orf9Q9BSY46
COMM domain-containing protein 1 (Protein Murr1)COMMD1 C2orf5 MURR1Q8N6686
COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)COPS7B CSN7BQ9H9Q26
CREB3 regulatory factor (Luman recruitment factor) (LRF)CREBRF C5orf41Q8IUR66
CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog)TEN1 C17orf106Q86WV56
CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3)CTDSPL C3orf8 NIF1 NIFL SCP3 YA22O151946
Cx9C motif-containing protein 4 (Mature T-cell proliferation 1 neighbor protein) (Mature T-cell proliferation-1 type A) (MTCP-1 type A) (Protein p8 MTCP-1) (p8MTCP1)CMC4 C6.1B MTCP1 MTCP1NBP562776
CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF)CXXC5 HSPC195 TCCCIA00297Q7LFL86
Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)CDK14 KIAA0834 PFTK1O949216
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)CDK6 CDKN6Q005346
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)CDK9 CDC2L4 TAKP507506
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)CDKN1B KIP1P465276
Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase)CDKN3 CDI1 CIP2 KAPQ166676
Cyclin-related protein FAM58A (Cyclin-M)FAM58AQ8N1B36
Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1)CSRP1 CSRP CYRPP212916
Cysteine-rich C-terminal protein 1 (Protein NICE-1)CRCT1 C1orf42 NICE1Q9UGL96
Cysteine-rich DPF motif domain-containing protein 1CDPF1 C22orf40Q6NVV76
Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3)CRIPT HSPC139Q9P0216
Cytochrome b561 (Cytochrome b-561)CYB561P494476
Cytochrome c oxidase assembly factor 5COA5 C2orf64Q86WW86
Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)MT-CO2 COII COXII MTCO2P004036
Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1)COX7A2L COX7AR COX7RPO145486
Cytochrome P450 4F22 (EC 1.14.14.-)CYP4F22Q6NT556
Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)ACO1 IREB1P213996
Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta)PITPNC1Q9UKF76
Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]PLA2G4A CPLA2 PLA2G4P477126
DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1)DAZAP1Q96EP56
DCN1-like protein 3 (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3)DCUN1D3Q8IWE46
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)DCAF8 H326 WDR42AQ5TAQ96
DDX11 proteinDDX11Q2NKM76
Death ligand signal enhancerKIAA0141 DELEQ141546
Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1)DAPK2Q9UIK46
Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short-chain dehydrogenase/reductase family member 4)DHRS4 UNQ851/PRO1800Q9BTZ26
Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)DENR DRP1 H14O435836
Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1)DOHH HLRC1Q9BU896
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)DSPP159246
Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase)QDPR DHPRP094176
Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]CTSC CPPIP536346
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3)NUDT3 DIPP DIPP1O959896
Disco-interacting protein 2 homolog B (DIP2 homolog B)DIP2B KIAA1463Q9P2656
DNA dC->dU-editing enzyme APOBEC-3C (A3C) (EC 3.5.4.-) (APOBEC1-like) (Phorbolin I)APOBEC3C APOBEC1L PBIQ9NRW36
DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)RBBP8 CTIPQ997086
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)MSH2P432466
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS-alpha 160 kDa subunit) (p160)MSH6 GTBPP527016
DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-)POLBP067466
DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase)REV1 REV1LQ9UBZ96
DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)XRCC2O435436
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)MCM2 BM28 CCNL1 CDCL1 KIAA0030P497366
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)MCM3P252056
DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme)TOP2A TOP2P113886
DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)DEDD2 FLAME3 PSEC0004Q8WXF86
DNA-binding protein RFX5 (Regulatory factor X 5)RFX5P483826
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)PRKDC HYRC HYRC1P785276
DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CAST) (CD3E-associated protein) (RNA polymerase I-associated factor PAF49)CD3EAP ASE1 CAST PAF49O154466
DNA-directed RNA polymerase II subunit RPB11-b1 (RNA polymerase II subunit B11-b1) (RPB11b1) (DNA-directed RNA polymerase II subunit J2)POLR2J2Q9GZM36
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)POLR2BP308766
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)POLR3AO148026
DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha)POLR2KP538036
DnaJ homolog subfamily A member 4DNAJA4Q8WW226
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)RPN2P048446
DTW domain-containing protein 2DTWD2Q8NBA86
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)MAP2K1 MEK1 PRKMK1Q027506
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)MAP2K2 MEK2 MKK2 PRKMK2P365076
Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y)DUSP15 C20orf57 VHYQ9H1R26
Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)DUSP3 VHRP514526
Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like)DYNLT3 TCTE1L TCTE1XLP518086
E3 SUMO-protein ligase NSE2 (EC 6.3.2.-) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)NSMCE2 C8orf36 MMS21Q96MF76
E3 ubiquitin-protein ligase ARIH1 (EC 6.3.2.-) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)ARIH1 ARI MOP6 UBCH7BP HUSSY-27Q9Y4X56
E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196)CHFR RNF196Q96EP16
E3 ubiquitin-protein ligase HECTD3 (EC 6.3.2.-) (HECT domain-containing protein 3)HECTD3Q5T4476
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