EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
E3 ubiquitin-protein ligase listerin (EC 6.3.2.-) (RING finger protein 160) (Zinc finger protein 294)LTN1 C21orf10 C21orf98 KIAA0714 RNF160 ZNF294 HSPC087O948226
E3 ubiquitin-protein ligase LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL)LRSAM1 TAL UNQ6496/PRO21356Q6UWE06
E3 ubiquitin-protein ligase RNF167 (EC 6.3.2.-) (RING finger protein 167) (RING105)RNF167 LP2254Q9H6Y76
E3 ubiquitin-protein ligase RNF31 (EC 6.3.2.-) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)RNF31 ZIBRAQ96EP06
E3 ubiquitin-protein ligase TRIM36 (EC 6.3.2.-) (RING finger protein 98) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728)TRIM36 RBCC728 RNF98Q9NQ866
E3 ubiquitin-protein ligase TRIP12 (EC 6.3.2.-) (E3 ubiquitin-protein ligase for Arf) (ULF) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)TRIP12 KIAA0045 ULFQ146696
Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)EGR1 KROX24 ZNF225P181466
Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2)EML2 EMAP2 EMAPL2O958346
Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]EDA ED1 EDA2Q928386
EF-hand domain-containing protein D1 (EF-hand domain-containing protein 1) (Swiprosin-2)EFHD1 SWS2 PP3051Q9BUP06
Egl nine homolog 2 (EC 1.14.11.29) (Estrogen-induced tag 6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)EGLN2 EIT6Q96KS06
ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21)ELAVL3 HUC PLE21Q145766
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)ETFDHQ161346
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)EPAS1 BHLHE73 HIF2A MOP2 PASD2Q998146
Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)EDC4 HEDLSQ6P2E96
Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7)MAP7Q142446
Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)EFNA4 EPLG4 LERK4P527986
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)EPS15 AF1PP425666
Estrogen nuclear receptor alphaESR1G4XH656
Ethanolamine kinase 1 (EKI 1) (EC 2.7.1.82)ETNK1 EKI1Q9HBU66
Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35)EIF3J EIF3S1 PRO0391O758226
Exocyst complex component 7 (Exocyst complex component Exo70)EXOC7 EXO70 KIAA1067Q9UPT56
Exportin-6 (Exp6) (Ran-binding protein 20)XPO6 KIAA0370 RANBP20Q96QU86
Eyes absent homolog 4 (EC 3.1.3.48)EYA4O956776
F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)FBXO32Q969P56
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)FBXW11 BTRCP2 FBW1B FBXW1B KIAA0696Q9UKB16
Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)FDPS FPS KIAA1293P143246
Fatty acid binding protein 5 (Psoriasis-associated)FABP5E7DVW56
Fatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)FABP5Q014696
Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)FGF2 FGFBP090386
FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP and FKBP-like) (WAFL)FKBP15 KIAA0674Q5T1M56
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)FEN1 RAD2P397486
FLYWCH family member 2FLYWCH2Q96CP26
Forkhead box protein D1 (Forkhead-related protein FKHL8) (Forkhead-related transcription factor 4) (FREAC-4)FOXD1 FKHL8 FREAC4Q166766
Forkhead box protein J2 (Fork head homologous X)FOXJ2 FHXQ9P0K86
Forkhead box protein K2 (Cellular transcription factor ILF-1) (FOXK1) (Interleukin enhancer-binding factor 1)FOXK2 ILF ILF1Q011676
Forkhead box protein O4 (Fork head domain transcription factor AFX1)FOXO4 AFX AFX1 MLLT7P981776
Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)]FTCDO959546
Fragile X mental retardation syndrome-related protein 2FXR2 FMR1L2P511166
Free fatty acid receptor 1 (G-protein coupled receptor 40)FFAR1 GPR40O148426
Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase)FAHP169306
FYN-binding protein (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)FYB SLAP130O151176
G antigen 4 (GAGE-4) (Cancer/testis antigen 4.4) (CT4.4)GAGE4Q130686
G antigen 7 (GAGE-7) (AL4) (Cancer/testis antigen 4.7) (CT4.7) (GAGE-12I) (GAGE-7B) (GAGE-8)GAGE7 GAGE12I GAGE7BO760876
G-protein coupled receptor 1GPR1P460916
G1/S-specific cyclin-D2CCND2P302796
Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase)GALTP079026
Galanin receptor type 3 (GAL3-R) (GALR-3)GALR3 GALNR3O607556
Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5)TXLNG CXorf15 ELRG LSR5Q9NUQ36
Gasdermin-B (Gasdermin-like protein)GSDMB GSDML PP4052 PRO2521Q8TAX96
Gasdermin-D (Gasdermin domain-containing protein 1)GSDMD DFNA5L GSDMDC1 FKSG10P577646
Gastrotropin (GT) (Fatty acid-binding protein 6) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (Intestinal bile acid-binding protein) (I-BABP)FABP6 ILBP ILLBPP511616
General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha)GTF2IRD2 GTF2IRD2AQ86UP86
Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)GLMN FAP48 FAP68 VMGLOMQ929906
Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79)GMEB2 KIAA1269Q9UKD16
Glucose-6-phosphatase 3 (G-6-Pase 3) (G6Pase 3) (EC 3.1.3.9) (Glucose-6-phosphatase beta) (G6Pase-beta) (Ubiquitous glucose-6-phosphatase catalytic subunit-related protein)G6PC3 UGRPQ9BUM16
Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)GID8 C20orf11Q9NWU26
Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)GCLM GLCLRP485076
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)GFPT2O948086
Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)GSTM3 GST5P212666
Glycerophosphodiester phosphodiesterase 1 (EC 3.1.4.44) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein)GDE1 MIR16Q9NZC36
Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]AGL GDEP355736
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)GSK3AP498406
Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160)GLG1 CFR1 ESL1 MG160Q928966
Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)GOLIM4 GIMPC GOLPH4 GPP130O004616
Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4)GRHL3 SOM TFCP2L4Q8TE856
Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]GRNP287996
Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand)GAS6 AXLLGQ143936
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)GRB7Q144516
Growth hormone-releasing hormone receptor (GHRH receptor) (Growth hormone-releasing factor receptor) (GRF receptor) (GRFR)GHRHRQ026436
GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1)GRPEL1 GREPEL1Q9HAV76
GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2)FRAT2O754746
GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35)GCHFR GFRPP300476
GTP-binding protein 1 (G-protein 1) (GP-1) (GP1)GTPBP1O001786
GTP-binding protein RAD (RAD1) (Ras associated with diabetes)RRAD RADP550426
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13GNG13Q9P2W36
Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (Epididymis tissue protein Li 17E) (Guanine nucleotide-binding protein subunit alpha-16) (G alpha-16) (G-protein subunit alpha-16)GNA15 GNA16P306796
HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3)HS1BP3Q53T596
Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2)HSPA2P546526
HemK methyltransferase family member 2 (EC 2.1.1.-) (M.HsaHemK2P) (N(6)-adenine-specific DNA methyltransferase 1)N6AMT1 C21orf127 HEMK2 PRED28Q9Y5N56
Hemoglobin subunit theta-1 (Hemoglobin theta-1 chain) (Theta-1-globin)HBQ1P091056
Heparan sulfate glucosamine 3-O-sulfotransferase 6HS3ST6C9JH646
Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]HGF HPTAP142106
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22)PDE7AQ139466
High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)SLC7A1 ATRC1 ERR REC1LP308256
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)HMG20A HMGX1 HMGXB1Q9NP666
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)HMGA2 HMGICP529266
Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF)KAT2B PCAFQ928316
Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)ASF1BQ9NVP26
Histone deacetylase 2 (HD2) (EC 3.5.1.98)HDAC2Q927696
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)SAP130Q9H0E36
Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)HIST1H1C H1F2P164036
Histone H1xH1FXQ925226
Histone H2AX (H2a/x) (Histone H2A.X)H2AFX H2AXP161046
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)HIST1H2BC H2BFL; HIST1H2BE H2BFH; HIST1H2BF H2BFG; HIST1H2BG H2BFA; HIST1H2BI H2BFKP628076
Histone H2B type 2-E (Histone H2B-GL105) (Histone H2B.q) (H2B/q)HIST2H2BE H2BFQQ167786
Histone H3.3C (Histone H3.5)H3F3CQ6NXT26
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)EHMT2 BAT8 C6orf30 G9A KMT1C NG36Q96KQ76
Histone-lysine N-methyltransferase SUV420H2 (EC 2.1.1.43) (Lysine N-methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2)SUV420H2 KMT5C PP7130Q86Y976
HLA class I histocompatibility antigen, A-1 alpha chain (MHC class I antigen A*1)HLA-A HLAAP304436
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