EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Mitogen-activated protein kinase 14 (Mitogen-activated protein kinase 14, isoform CRA_e)MAPK14 hCG_1818055L7RSM26
Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)MAPK15 ERK7 ERK8Q8TD086
Mitogen-activated protein kinase 8 interacting protein 1MAPK8IP1Q6NUQ96
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)MAP3K11 MLK3 PTK1 SPRKQ165846
MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein)MMS19 MMS19LQ96T766
MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A)MOB3A MOBKL2AQ96BX86
MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C)MOB3C MOBKL2CQ70IA86
Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4)MOAP1 PNMA4Q96BY26
Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)SLC16A3 MCT4O154276
Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5)SLC16A5 MCT5 MCT6O153756
Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL)MGLLQ996856
MORF4 family-associated protein 1 (Protein PGR1) (Protein associated with MRG of 14 kDa)MRFAP1 PAM14 PGR1Q9Y6056
MRG/MORF4L-binding protein (MRG-binding protein)MRGBP C20orf20Q9NV566
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]MUC1 PUMP159416
Mucolipin-1 (MG-2) (Mucolipidin)MCOLN1 ML4 MSTP080Q9GZU16
MUS81 endonuclease homolog (Fragment)0Q53ES56
Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC 3.1.1.93) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10)ABHD10Q9NUJ16
Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10)MTMR3 KIAA0371 ZFYVE10Q136156
Myotubularin-related protein 9MTMR9 C8orf9 MTMR8Q96QG76
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)DDAH1 DDAHO947606
N-terminal EF-hand calcium-binding protein 3 (Amyloid beta A4 protein-binding family A member 2-binding protein) (Nek2-interacting protein 1) (Neuronal calcium-binding protein 3) (X11L-binding protein 51)NECAB3 APBA2BP NIP1 SYTIP2 XB51Q96P716
NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase)NADKO955446
NAD(P) transhydrogenase, mitochondrial (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)NNTQ134236
NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (YjeF N-terminal domain-containing protein 1) (YjeF_N1)APOA1BP AIBP YJEFN1Q8NCW56
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)SIRT5 SIR2L5Q9NXA86
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit)NDUFA13 GRIM19 CDA016 CGI-39Q9P0J06
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit)NDUFA2O436786
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit)NDUFB1O754386
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit)NDUFV1 UQOR1P498216
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4)NDUFV3P561816
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit)NDUFS4O431816
NecdinNDNQ996086
NEDD4-binding protein 2-like 2 (Phosphonoformate immuno-associated protein 5)N4BP2L2 CG005 PFAAP5Q928026
Negative elongation factor C/D (NELF-C/D) (TH1-like protein)NELFCD NELFD TH1 TH1L HSPC130Q8IXH76
Neurogranin (Ng) (RC3) [Cleaved into: NEUG(55-78)]NRGNQ926866
NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER)NAB2 MADERQ157426
NIPA-like protein 3NIPAL3 NPAL3Q6P4996
Nitric oxide-associated protein 1NOA1 C4orf14Q8NC606
NOMO3 protein (Fragment)NOMO3Q1LZN26
Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 6.3.2.-)NSMCE1 HSPC333 HSPC337Q8WV226
Non-syndromic hearing impairment protein 5 (Inversely correlated with estrogen receptor expression 1) (ICERE-1)DFNA5 ICERE1O604436
Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)NCBP2 CBP20 PIG55P522986
Nuclear export mediator factor NEMF (Antigen NY-CO-1) (Serologically defined colon cancer antigen 1)NEMF SDCCAG1O605246
Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein)NFIA KIAA1439Q128576
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)NFE2L2 NRF2Q162366
Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205)NUP205 C7orf14 KIAA0225Q926216
Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88)NUP88Q995676
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)NCOA3 AIB1 BHLHE42 RAC3 TRAM1Q9Y6Q96
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)NCOA6 AIB3 KIAA0181 RAP250 TRBPQ146866
Nuclear receptor corepressor 2NCOR2C9JFD36
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)NUCKS1 NUCKS JC7Q9H1E36
Nucleolar protein 14 (Nucleolar complex protein 14)NOP14 C4orf9 NOL14 RES4-25P783166
Nucleolysin TIAR (TIA-1-related protein)TIAL1Q010856
Nucleoporin GLE1 (hGLE1) (GLE1-like protein)GLE1 GLE1LQ53GS76
Nucleoporin p58/p45 (Nucleoporin-like protein 1)NUPL1 KIAA0410Q9BVL26
Nucleoside diphosphate-linked moiety X motif 22 (Nudix motif 22)NUDT22 PP11246Q9BRQ36
O-acetyl-ADP-ribose deacetylase MACROD1 (EC 3.2.2.-) (EC 3.5.1.-) (MACRO domain-containing protein 1) (Protein LRP16) ([Protein ADP-ribosylglutamate] hydrolase)MACROD1 LRP16Q9BQ696
OCIA domain-containing protein 1 (Ovarian carcinoma immunoreactive antigen)OCIAD1 OCIAQ9NX406
Olfactory receptor 11H1 (Olfactory receptor OR22-1)OR11H1Q8NG946
Olfactory receptor 4F17 (Olfactory receptor 4F11) (Olfactory receptor 4F18) (Olfactory receptor 4F19)OR4F17 OR4F11P OR4F18 OR4F19Q8NGA86
Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor)OGFRQ9NZT26
Osteoclast-stimulating factor 1OSTF1Q928826
Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)SPP1 BNSP OPN PSEC0156P104516
OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)OTUD7B ZA20D1Q6GQQ96
Outer dense fiber protein 3-like protein 2ODF3L2 C19orf19Q3SX646
Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)OSBPL9 ORP9 OSBP4Q96SU46
ParathymosinPTMSP209626
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)PARD3 PAR3 PAR3AQ8TEW06
PCI domain-containing protein 2 (CSN12-like protein)PCID2 HT004Q5JVF36
Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14)PTX3 TNFAIP5 TSG14P260226
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)NGLY1 PNG1Q96IV06
Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D)PPID CYP40 CYPDQ087526
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)PPIF CYP3P304056
Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase)FKBP14 FKBP22 UNQ322/PRO381Q9NWM86
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)FKBP8 FKBP38Q143186
Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3)PPIL3Q9H2H86
Peroxiredoxin-4 (EC 1.11.1.15) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372)PRDX4Q131626
Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MPF-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]HSD17B4 EDH17B4P516596
PH-interacting protein (PHIP) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)PHIP WDR11Q8WWQ06
PHD finger protein 14PHF14 KIAA0783O948806
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)FARSA FARS FARSL FARSLAQ9Y2856
Phosphatase and tensin-like protein0F6KD016
Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.-) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 5-phosphatase 2) (hSAC2)INPP5F KIAA0966 SAC2 MSTP007 MSTP047Q9Y2H26
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)PIK3R1 GRB1P279866
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta)PIK3CB PIK3C1P423386
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)PIP4K2A PIP5K2 PIP5K2AP484266
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase)PCK2 PEPCK2Q168226
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)PRPSAP1Q145586
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2)PHKG2P157356
Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT)PSAT1 PSAQ9Y6176
Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)PHYH PAHXO148326
Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A)PIEZO1 FAM38A KIAA0233Q925086
Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)PTTG1IP C21orf1 C21orf3P538016
Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)PHLDA2 BWR1C HLDA2 IPL TSSC3Q53GA46
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)PLEC PLEC1Q151496
Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2)PARP2 ADPRT2 ADPRTL2Q9UGN56
Polycomb protein SCMH1 (Sex comb on midleg homolog 1)SCMH1Q96GD36
Potassium channel subfamily K member 7KCNK7Q9Y2U26
Potassium voltage-gated channel subfamily H member 6 (Ether-a-go-go-related gene potassium channel 2) (ERG-2) (Eag-related protein 2) (Ether-a-go-go-related protein 2) (hERG-2) (hERG2) (Voltage-gated potassium channel subunit Kv11.2)KCNH6 ERG2Q9H2526
POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2)POTEE A26C1A POTE2Q6S8J36
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