EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Pre-miRNA 5'-monophosphate methyltransferase (EC 2.1.1.-) (BCDIN3 domain-containing protein)BCDIN3DQ7Z5W36
Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17)CDC40 EHB3 PRP17 PRPF17O605086
Pre-mRNA-splicing factor SLU7 (hSlu7)SLU7O953916
Prefoldin subunit 1PFDN1 PFD1O609256
Prefoldin subunit 4 (Protein C-1)PFDN4 PFD4Q9NQP46
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]PSEN1 AD3 PS1 PSNL1P497686
Presenilins-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]PARL PSARL PRO2207Q9H3006
PRKR-interacting protein 1PRKRIP1Q9H8756
Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49)DDX49Q9Y6V76
Probable histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)HARS2 HARSL HARSR HO3P495906
Probable palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399)ZDHHC11 ZNF399Q9H8X96
Proline and serine-rich protein 2PROSER2 C10orf47Q86WR76
Proline/serine-rich coiled-coil protein 1PSRC1 DDA3 FP3214Q6PGN96
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)PCCBP051666
Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) (Protein FAM213B)FAM213B C1orf93Q8TBF26
Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1)PSMG2 HCCA3 PAC2 TNFSF5IP1Q969U76
Proteasome subunit alpha type-3 (EC 3.4.25.1) (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)PSMA3 HC8 PSC8P257886
Protein AF-10 (ALL1-fused gene from chromosome 10 protein)MLLT10 AF10P551976
Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4)CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426Q9Y2B06
Protein CNPPD1 (Cyclin Pas1/PHO80 domain-containing protein 1)CNPPD1 C2orf24 CDABP0125 CGI-57Q9BV876
Protein DPCDDPCDQ9BVM26
Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)DR1Q016586
Protein eva-1 homolog B (Protein FAM176B)EVA1B C1orf78 FAM176BQ9NVM16
Protein FAM104BFAM104B CXorf44Q5XKR96
Protein FAM134AFAM134A C2orf17Q8NC446
Protein FAM167AFAM167A C8orf13Q96KS96
Protein FAM172AFAM172A C5orf21Q8WUF86
Protein FAM177A1FAM177A1 C14orf24Q8N1286
Protein FAM181AFAM181A C14orf152 HSD-31 HSD31Q8N9Y46
Protein FAM181BFAM181BA6NEQ26
Protein FAM3A (Cytokine-like protein 2-19)FAM3A 2-19 2.19P981736
Protein FAM3C (Interleukin-like EMT inducer)FAM3C ILEI GS3786Q925206
Protein FAM86AFAM86A SB153Q96G046
Protein FAM98BFAM98BQ52LJ06
Protein FAN (Factor associated with neutral sphingomyelinase activation) (Factor associated with N-SMase activation)NSMAF FANQ926366
Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta)FNTBP493566
Protein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein)FEM1A EPRAPQ9BSK46
Protein hairlessHRO435936
Protein IMPACT (Imprinted and ancient gene protein homolog)IMPACTQ9P2X36
Protein ITFG3ITFG3 C16orf9Q9H0X46
Protein KHNYN (KH and NYN domain-containing protein)KHNYN KIAA0323O150376
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)PRKCB PKCB PRKCB1P057716
Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8)ZMYND8 KIAA1125 PRKCBP1 RACK7Q9ULU46
Protein kish-B (Transmembrane protein 167B)TMEM167B C1orf119 AD-020Q9NRX66
Protein LDOC1 (Leucine zipper protein down-regulated in cancer cells)LDOC1 BCUR1O957516
Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein)TMBIM4 GAAP LFG4 CGI-119Q9HC246
Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42)NDRG1 CAP43 DRG1 RTPQ925976
Protein orai-2 (CAP-binding protein complex-interacting protein 2) (Transmembrane protein 142B)ORAI2 C7orf19 CBCIP2 TMEM142B PP1729Q96SN76
Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (KLRAQ motif-containing protein 1)PPP1R21 CCDC128 KLRAQ1Q6ZMI06
Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)PPM1B PP2CBO756886
Protein Red (Cytokine IK) (IK factor) (Protein RER)IK RED RERQ131236
Protein rogdi homologROGDIQ9GZN76
Protein RTF2 homolog (Replication termination factor 2 domain-containing protein 1)RTFDC1 C20orf43 AD-007 CDA05 HSPC164 HSPC169Q9BY426
Protein SEC13 homolog (SEC13-like protein 1) (SEC13-related protein)SEC13 D3S1231E SEC13L1 SEC13RP557356
Protein spire homolog 1 (Spir-1)SPIRE1 KIAA1135 SPIR1Q08AE86
Protein SZT2 (Seizure threshold 2 protein homolog)SZT2 C1orf84 KIAA0467Q5T0116
Protein Tob1 (Transducer of erbB-2 1)TOB1 TOB TROB1P506166
Protein tweety homolog 1 (hTTY1)TTYH1Q9H3136
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)UNC45A SMAP1Q9H3U16
Protein YIPF2 (YIP1 family member 2)YIPF2Q9BWQ66
Protein-lysine methyltransferase METTL21B (EC 2.1.1.-) (Hepatocellular carcinoma-associated antigen 557a) (Methyltransferase-like protein 21B)METTL21B FAM119B HCA557AQ96AZ16
Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2)TPST2O607046
Putative deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein)TATDN1 CDA11Q6P1N96
Putative deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)DERA CGI-26Q9Y3156
Putative double homeobox protein 3DUX3Q96PT46
Putative glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5)GK5Q6ZS866
Putative glycosyltransferase ALG1-like (EC 2.4.1.-)ALG1LQ6GMV16
Putative L-aspartate dehydrogenase (EC 1.4.1.21) (Aspartate dehydrogenase domain-containing protein)ASPDHA6ND916
Putative methyl-CpG-binding domain protein 3-like 3 (MBD3-like protein 3)MBD3L3A6NE826
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16)DHX16 DBP2 DDX16 KIAA0577O602316
Putative RNA-binding protein 3 (RNA-binding motif protein 3) (RNPL)RBM3 RNPLP981796
Putative uncharacterized protein DKFZp434H204 (Fragment)DKFZp434H204Q9UFZ46
Putative uncharacterized protein DKFZp666O0110DKFZp666O0110Q658W26
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)PDHA1 PHE1AP085596
Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Protein 4P11) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog)CRYZL1 4P11O958256
Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein)RAB3IP RABIN8Q96QF06
Rab11 family-interacting protein 3 (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148)RAB11FIP3 ARFO1 KIAA0665O751546
RAB13 protein (Fragment)RAB13Q504R66
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta)AKT2P317516
RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1)RINT1Q6NUQ16
Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)RAPGEF1 GRF2Q139056
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)RASA1 RASAP209366
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1Q70E736
Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)RAB13 GIG4P511536
Ras-related protein Rab-24RAB24Q969Q56
Ras-related protein Rab-34 (Ras-related protein Rab-39) (Ras-related protein Rah)RAB34 RAB39 RAHQ9BZG16
Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Protein Rar)RAB40B SEC4LQ128296
Ras-related protein Rap-1A (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)RAP1A KREV1P628346
Ras-related protein Rap-2a (RbBP-30)RAP2AP101146
Regulation of nuclear pre-mRNA domain-containing protein 2RPRD2 KIAA0460 HSPC099Q5VT526
Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1)UPF1 KIAA0221 RENT1Q929006
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)RFC5P409376
Replication initiator 1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464)REPIN1 RIP60 ZNF464Q9BWE06
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]RPA1 REPA1 RPA70P276946
Reticulocalbin-1RCN1 RCNQ152936
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)RXRA NR2B1P197936
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)ARHGDIA GDIA1P525656
Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)ARHGAP35 GRF1 GRLF1 KIAA1722Q9NRY46
Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)ARHGEF18 KIAA0521Q6ZSZ56
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314Q141556
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