EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)RHOD ARHDO002126
Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4)RHBDD1 RHBDL4 HSD-50 HSD50Q8TEB96
RhotekinRTKN RTKN1Q9BST96
Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C)RNASEH2C AYP1Q8TDP16
Ribonuclease T2 (EC 3.1.27.-) (Ribonuclease 6)RNASET2 RNASE6PLO005846
Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)PRPS2P119086
Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog)BMS1 BMS1L KIAA0187Q146926
Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.99.2) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)NQO2 NMOR2P160836
RING finger protein 11RNF11 CGI-123Q9Y3C56
RING finger protein 141 (Zinc finger protein 230)RNF141 ZNF230Q8WVD56
RING finger protein 17 (Tudor domain-containing protein 4)RNF17 TDRD4Q9BXT86
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16)SSU72 HSPC182 PNAS-120Q9NP776
RNA pseudouridylate synthase domain-containing protein 1 (Ribosomal large subunit pseudouridine synthase C-like protein)RPUSD1 C16orf40 RLUCLQ9UJJ76
RNA-binding protein 47 (RNA-binding motif protein 47)RBM47A0AV966
RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)RBM4B RBM30Q9BQ046
RNA-binding protein with multiple splicing 2RBPMS2Q6ZRY46
SAC3 domain-containing protein 1SAC3D1F8WC896
Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein)SLMAP KIAA1601 SLAP UNQ1847/PRO3577Q14BN46
Sarcoplasmic reticulum histidine-rich calcium-binding proteinHRC HCPP233276
SEC14-like protein 1SEC14L1 SEC14LQ925036
SEC23-interacting protein (p125)SEC23IP MSTP053Q9Y6Y86
Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1)SCAMP1 SCAMPO151266
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)DVL1O146406
Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein)BSCL2Q96G976
Selenoprotein N (SelN)SEPN1 SELNQ9NZV56
Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1)RSRC1 SRRP53 BM-011Q96IZ76
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)ATR FRP1Q135356
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)CDC42BPB KIAA1124Q9Y5S26
Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)PKN1 PAK1 PKN PRK1 PRKCL1Q165126
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)NEK1 KIAA1901Q96PY66
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)PLK1 PLKP533506
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)PRPF4B KIAA0536 PRP4 PRP4H PRP4KQ135236
Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)SGK1 SGKO001416
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)SIK3 KIAA0999 QSK L19Q9Y2K26
Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)TLK1 KIAA0137Q9UKI86
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)PPP2R2AP631516
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)ANKRD28 KIAA0379O150846
Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase-interacting protein A) (IPIP27A)FAM109AQ8N4B16
Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a (cDNA FLJ77999, highly similar to Homo sapiens sialophorin (gpL115, leukosialin, CD43), mRNA) (cDNA, FLJ94351, Homo sapiens sialophorin (gpL115, leukosialin, CD43) (SPN), mRNA)SPN hCG_21624A8K9B16
Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)SPCS1 SPC12 HSPC033Q9Y6A96
Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha)SRPRP082406
Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)SRP68Q9UHB96
Similar to E2F transcription factor 1 (Fragment)0Q9BSD86
Single-pass membrane protein with aspartate-rich tail 1, mitochondrialSMDT1 C22orf32Q9H4I96
Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)SSBP3 SSDP SSDP1Q9BWW46
Single-stranded DNA-binding protein 4SSBP4Q9BWG46
Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)PDS5B APRIN AS3 KIAA0979Q9NTI56
Sjoegren syndrome/scleroderma autoantigen 1 (Autoantigen p27)SSSCA1O602326
Small G protein signaling modulator 2 (RUN and TBC1 domain-containing protein 1)SGSM2 KIAA0397 RUTBC1O431476
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP)SGTA SGT SGT1O437656
Small integral membrane protein 7SMIM7 C19orf42Q9BQ496
snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit)SNAPC4 SNAP190Q5SXM26
Sodium channel modifier 1SCNM1Q9BWG66
Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6)SLC6A6P316416
Solute carrier family 1 (Neutral amino acid transporter), member 5 variant (Fragment)0Q59ES36
Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR)SLC22A17 BOCT BOITQ8WUG56
Solute carrier family 25 member 43SLC25A43Q8WUT96
Sorting nexin-7SNX7Q9UNH66
Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)SPG20 KIAA0610 TAHCCP1Q8N0X76
SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP)SPATS2L DNAPTP6 SP1224Q9NUQ66
Specifically androgen-regulated gene proteinSARG C1orf116Q9BW046
Spermatogenesis-associated protein 2-like protein (SPATA2-like protein)SPATA2L C16orf76Q8IUW36
Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)VIPAS39 C14orf133 SPE39 VIPARQ9H9C16
Sphingolipid delta(4)-desaturase DES1 (EC 1.14.-.-) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Membrane lipid desaturase)DEGS1 DES1 MLD MIG15O151216
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)SFPQ PSFP232466
Stannin (AG8_1)SNNO753246
Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)SND1 TDRD11Q7KZF46
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)ESRRA ERR1 ESRL1 NR3B1P114746
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)NSDHL H105E3Q157386
Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66)TMEM66 SARAF XTP3 HSPC035 NPD003 PSEC0019 UNQ1967/PRO4499Q96BY96
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1Q146836
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog)SMC4 CAPC SMC4L1Q9NTJ36
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)SMC6 SMC6L1Q96SB86
Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)SULT1A1 STP STP1 OK/SW-cl.88P502256
Sulfotransferase family cytosolic 2B member 1 (ST2B1) (Sulfotransferase 2B1) (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2)SULT2B1 HSST2O002046
Suppression of tumorigenicity 5 protein (DENN domain-containing protein 2B) (HeLa tumor suppression 1)ST5 DENND2B HTS1P785246
SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4)SUGP1 SF4Q8IWZ86
Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1)SMNDC1 SMNR SPF30O759406
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)SMARCA5 SNF2H WCRF135O602646
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)SMARCB1 BAF47 INI1 SNF5L1Q128246
Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV)SYT15Q9BQS26
Syntaxin-10 (Syn10)STX10 SYN10O604996
Syntaxin-12STX12Q86Y826
Syntaxin-16 (Syn16)STX16O146626
Syntaxin-6STX6O437526
Syntaxin-7STX7O154006
T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1)TCAIM C3orf23 TOAG1Q8N3R36
Tastin (Trophinin-assisting protein) (Trophinin-associated protein)TROAPQ128156
TATA box binding protein (TATA box binding protein, isoform CRA_a)TBP hCG_2029691Q32MN76
TATA box-binding protein-like protein 1 (TBP-like protein 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein)TBPL1 TLF TLP TLP21 TRF2 TRPP623806
TBC1 domain family member 16TBC1D16Q8TBP06
TBC1 domain family member 3 (Prostate cancer gene 17 protein) (Protein TRE17-alpha) (Rab GTPase-activating protein PRC17)TBC1D3 PRC17 TBC1D3AQ8IZP16
TBC1 domain family member 3BTBC1D3B TBC1D3IA6NDS46
TBC1 domain family member 3GTBC1D3GQ6DHY56
TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)TBC1D4 AS160 KIAA0603O603436
TBC1 domain family member 5TBC1D5 KIAA0210Q926096
TBC1 domain family member 7 (Cell migration-inducing protein 23)TBC1D7 HSPC239 TBC7Q9P0N96
Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (SKI3 homolog) (Ski3) (Tricho-hepatic-enteric syndrome protein) (Thespin)TTC37 KIAA0372Q6PGP76
Tetratricopeptide repeat protein 38 (TPR repeat protein 38)TTC38Q5R3I46
THAP domain-containing protein 8THAP8Q8NA926
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