EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14)TMX2 TXNDC14 CGI-31 My009 PIG26 PSEC0045 UNQ237/PRO270Q9Y3206
Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS)TARSP266396
Thrombospondin-1THBS1 TSP TSP1P079966
Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)TYMP ECGF1P199716
Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)DTYMK CDC8 TMPK TYMKP239196
Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]TMSB4X TB4X THYB4 TMSB4P623286
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)THRA EAR7 ERBA1 NR1A1 THRA1 THRA2P108276
TLC domain-containing protein 2TLCD2A6NGC46
TM2 domain-containing protein 1 (Beta-amyloid-binding protein) (hBBP)TM2D1 BBPQ9BX746
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)TNIP1 KIAA0113 NAF1Q150256
Toll-like receptor 4 (hToll) (CD antigen CD284)TLR4O002066
TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1)TOX4 C14orf92 KIAA0737O948426
Trafficking protein particle complex subunit 2-like proteinTRAPPC2L HSPC126Q9UL336
Trafficking protein particle complex subunit 5TRAPPC5Q8IUR06
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)SUPT5H SPT5 SPT5HO002676
Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)TFAP2A AP2TF TFAP2P055496
Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU)BRF2 BRFU PRO1470Q9HAW06
Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2)BRF1 BRF GTF3B TAF3B2 TAF3CQ929946
Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)OVOL2 ZNF339Q9BRP06
Transcription factor SOX-6SOX6P357126
Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28)TAF11 TAF2I PRO2134Q155446
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (Tripartite motif-containing protein 24)TRIM24 RNF82 TIF1 TIF1AO151646
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28)TRIM28 KAP1 RNF96 TIF1BQ132636
Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]GLI3P100716
Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)TEAD2 TEF4Q155626
Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I)TACO1 CCDC44 PRO0477Q9BSH46
Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)SSR1 TRAPA PSEC0262P433076
Transmembrane 4 L6 family member 1 (Membrane component chromosome 3 surface marker 1) (Tumor-associated antigen L6)TM4SF1 M3S1 TAAL6P304086
Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26)TMED3 C15orf22 UNQ5357/PRO1078Q9Y3Q36
Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4)P4HTM PH4Q9NXG66
Transmembrane protein 106C (Endoplasmic reticulum membrane protein overexpressed in cancer)TMEM106C EMOCQ9BVX26
Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52)TMEM135Q86UB96
Transmembrane protein 14BTMEM14BQ9NUH86
Transmembrane protein 251TMEM251 C14orf109Q8N6I46
Transmembrane protein 54 (Beta-casein-like protein) (Protein CAC-1)TMEM54 BCLP CAC1Q969K76
Transmembrane protein 80TMEM80Q96HE86
Tribbles homolog 2 (TRB-2)TRIB2 TRB2Q925196
Tripartite motif-containing protein 14TRIM14 KIAA0129Q141426
Tripartite motif-containing protein 16 (Estrogen-responsive B box protein)TRIM16 EBBPO953616
tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.-) (HpaII tiny fragments locus 9c protein)TRMT2A HTF9CQ8IZ696
tRNA 2'-phosphotransferase 1 (EC 2.7.1.160)TRPT1Q86TN46
TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)TSC22D2 KIAA0669 TILZ4O751576
Tubulin alpha-1A chain (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain)TUBA1A TUBA3Q71U366
Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (SRC1 and TIF2-associated modulatory protein) (Tubulin--tyrosine ligase-like protein 5)TTLL5 KIAA0998 STAMPQ6EMB26
Tubulin--tyrosine ligase-like protein 12TTLL12 KIAA0153Q141666
Tudor domain-containing protein 3TDRD3Q9H7E26
TuftelinTUFT1Q9NNX16
Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL)TNFSF9P412736
Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)TNFRSF12A FN14Q9NP846
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)TRADDQ156286
Tumor protein p73 (p53-like transcription factor) (p53-related protein)TP73 P73O153506
Type 2 lactosamine alpha-2,3-sialyltransferase (EC 2.4.99.-) (CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI) (ST3Gal VI) (ST3GalVI) (Sialyltransferase 10)ST3GAL6 SIAT10Q9Y2746
TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)TYROBP DAP12 KARAPO439146
Tyrosine-protein kinase (EC 2.7.10.2)0A8K4G26
Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2)BAZ1B WBSC10 WBSCR10 WBSCR9 WSTFQ9UIG06
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)JAK2O606746
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)LCKP062396
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRPP783246
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)LSM2 C6orf28 G7BQ9Y3336
U6 snRNA-associated Sm-like protein LSm6LSM6P623126
Ubiquinone biosynthesis protein COQ9, mitochondrialCOQ9 C16orf49 HSPC326 PSEC0129O752086
Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)USP13 ISOT3Q929956
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)USP21 USP23 PP1490Q9UK806
Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)USP22 KIAA1063 USP3LQ9UPT96
Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)USP33 KIAA1097 VDU1Q8TEY76
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)USP5 ISOTP459746
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)USP7 HAUSPQ930096
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)UCHL3P153746
Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog)UBFD1 UBPHO145626
Ubiquitin-conjugating enzyme E2 D4 (EC 6.3.2.19) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)UBE2D4 UBCH5DQ9Y2X86
Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2)UBE2Q2Q8WVN86
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)UBE2V1 CROC1 UBE2V UEV1 P/OKcl.19Q134046
UNC93B1 protein (Fragment)UNC93B1Q58F166
Uncharacterized protein C15orf52C15orf52Q6ZUT66
Uncharacterized protein C16orf11 (Uncharacterized protein RJD1)C16orf11P0CG206
Uncharacterized protein C2orf27C2orf27A; C2orf27BQ580R06
Uncharacterized protein C8orf76C8orf76Q96K316
Uncharacterized protein KIAA1211-likeKIAA1211L C2orf55Q6NV746
Unconventional myosin-IXb (Unconventional myosin-9b)MYO9B MYR5Q134596
Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)MYO5A MYH12Q9Y4I16
UPF0568 protein C14orf166 (CLE7 homolog) (CLE)C14orf166 CGI-99Q9Y2246
UPF0586 protein C9orf41C9orf41Q8N4J06
UPF0587 protein C1orf123C1orf123Q9NWV46
UPF0693 protein C10orf32C10orf32Q96B456
UPF0705 protein C11orf49C11orf49Q9H6J76
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)UNG DGU UNG1 UNG15P130516
Uridine diphosphate glucose pyrophosphatase (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14)NUDT14 UGPPO958486
Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3)UPP1 UPQ168316
Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)UCK2 UMPKQ9BZX26
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)PLAUR MO3 UPARQ034056
Uroplakin-2 (UP2) (Uroplakin II) (UPII)UPK2O005266
UV-stimulated scaffold protein AUVSSA KIAA1530Q2YD986
Uveal autoantigen with coiled-coil domains and ankyrin repeatsUACA KIAA1561Q9BZF96
V-type proton ATPase subunit e 2 (V-ATPase subunit e 2) (Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2) (Vacuolar proton pump subunit e 2)ATP6V0E2 ATP6V0E2L C7orf32Q8NHE46
Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)VMA21 MEAX XMEAQ3ZAQ76
Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)VPS26A VPS26O754366
Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)VPS37C PML39A5D8V66
Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)VPS45 VPS45A VPS45BQ9NRW76
Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog)VPS51 ANG2 C11orf2 C11orf3 FFR PP5382Q9UID36
Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA)BPHL MCNAAQ86WA66
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