EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)SLC44A1 CD92 CDW92 CTL1Q8WWI55
Choline transporter-like protein 2 (Solute carrier family 44 member 2)SLC44A2 CTL2 PSEC0210Q8IWA55
Choline transporter-like protein 4 (Solute carrier family 44 member 4)SLC44A4 C6orf29 CTL4 NG22 UNQ441/PRO874Q53GD35
Cholinergic receptor, nicotinic, beta 2 (Neuronal) (cDNA, FLJ94017, Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 2(neuronal) (CHRNB2), mRNA)CHRNB2 hCG_18732Q5SXY35
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)CBX5 HP1AP459735
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)CHD8 HELSNF1 KIAA1564Q9HCK85
Chymotrypsinogen B2 (EC 3.4.21.1) [Cleaved into: Chymotrypsin B2 chain A; Chymotrypsin B2 chain B; Chymotrypsin B2 chain C]CTRB2Q6GPI15
Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)CIZ1 LSFR1 NP94 ZNF356Q9ULV35
CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)CMTM4 CKLFSF4Q8IZR55
Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)CLINT1 ENTH EPN4 EPNR KIAA0171Q146775
Claudin-2 (SP82)CLDN2 PSEC0059 SP82 UNQ705/PRO1356P577395
Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)CPSF3 CPSF73Q9UKF65
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)ST3GAL1 SIAT4 SIAT4AQ112015
Coactosin-like proteinCOTL1 CLPQ140195
Coiled-coil domain-containing protein 114CCDC114Q96M635
Coiled-coil domain-containing protein 124CCDC124Q96CT75
Coiled-coil domain-containing protein 14CCDC14Q49A885
Coiled-coil domain-containing protein 174CCDC174 C3orf19Q6PII35
Coiled-coil domain-containing protein 50 (Protein Ymer)CCDC50 C3orf6Q8IVM05
Coiled-coil domain-containing protein 94CCDC94Q9BW855
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 (28S ribosomal protein S37, mitochondrial) (MRP-S37) (Nuclear protein C2360)CHCHD1 C10orf34 MRPS37Q96BP25
Collagen alpha-1(IV) chain [Cleaved into: Arresten]COL4A1P024625
Collagen alpha-2(I) chain (Alpha-2 type I collagen)COL1A2P081235
Collagen alpha-2(IV) chain [Cleaved into: Canstatin]COL4A2P085725
Collagen alpha-3(VI) chainCOL6A3P121115
Collagen type IV alpha-3-binding protein (Ceramide transfer protein) (hCERT) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11)COL4A3BP CERT STARD11Q9Y5P45
COMM domain-containing protein 7COMMD7 C20orf92Q86VX25
Complexin-3 (Complexin III) (CPX III)CPLX3 Nbla11589Q8WVH05
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)COPS2 CSN2 TRIP15P612015
Copine-6 (Copine VI) (Neuronal-copine) (N-copine)CPNE6O957415
Copine-7 (Copine VII)CPNE7Q9UBL65
Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone)CCSO146185
Copper-transporting ATPase 2 (EC 3.6.3.54) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]ATP7B PWD WC1 WNDP356705
Cordon-bleu protein-like 1COBLL1 KIAA0977Q53SF75
Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96)CORO2B KIAA0925Q9UQ035
COX assembly mitochondrial protein 2 homologCMC2 C16orf61 DC13Q9NRP25
CpG-binding protein (CXXC-type zinc finger protein 1) (PHD finger and CXXC domain-containing protein 1)CXXC1 CFP1 CGBP PCCX1 PHF18Q9P0U45
CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein)CLMP ACAM ASAM UNQ318/PRO363Q9H6B45
Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)ATF1P188465
Cyclic nucleotide-gated cation channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-1) (CNG channel beta-1) (Glutamic acid-rich protein) (GARP)CNGB1 CNCG2 CNCG3L CNCG4 RCNC2Q140285
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)CDK7 CAK CAK1 CDKN7 MO15 STK1P506135
Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)CST3P010345
Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagin-1) (Autophagy-related cysteine endopeptidase 1) (Autophagy-related protein 4 homolog B) (hAPG4B)ATG4B APG4B AUTL1 KIAA0943Q9Y4P15
Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP)CRIP1 CRIP CRP1P502385
Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP)CSRP2BPQ9H8E85
Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12)CSRNP2 C12orf22 FAM130A1 TAIP12Q9H1755
CystinosinCTNSO609315
Cytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 6.4 kDa protein)UQCR11 UQCRO149575
Cytochrome cCYCS CYCP999995
Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing protein 8) (E2-induced gene 2 protein)COA4 CHCHD8 E2IG2Q9NYJ15
Cytochrome c oxidase subunit 6A2, mitochondrial (Cytochrome c oxidase polypeptide VIa-heart) (COXVIAH) (Cytochrome c oxidase subunit VIA-muscle) (COX VIa-M)COX6A2 COX6A COX6AHQ022215
Cytokine receptor-like factor 1 (Cytokine-like factor 1) (CLF-1) (ZcytoR5)CRLF1 UNQ288/PRO327O754625
Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96)ENGASEQ8NFI35
Cytosolic Fe-S cluster assembly factor NUBP1 (Nucleotide-binding protein 1) (NBP 1)NUBP1 NBP NBP1P533845
Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II)NT5C2 NT5B NT5CP PNT5P499025
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase)BDH1 BDHQ023385
DCN1-like protein 4 (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)DCUN1D4 KIAA0276Q925645
DCN1-like protein 5 (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5)DCUN1D5Q9BTE75
DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1)DCAF13 WDSOF1 HSPC064Q9NV065
Dehydrogenase/reductase SDR family member 11 (EC 1.-.-.-)DHRS11 UNQ836/PRO1774Q6UWP25
Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3)DLL3Q9NYJ75
DENN domain-containing protein 4BDENND4B KIAA0476O750645
Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1)DNTTIP1 C20orf167 TDIF1Q9H1475
Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2)DSE SART2Q9UL015
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)DLD GCSL LAD PHE3P096225
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)DPYSL3 CRMP4 DRP3 ULIP ULIP1Q141955
Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase)DPP7 DPP2 QPPQ9UHL45
Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4)NUDT4 DIPP2 KIAA0487 HDCMB47PQ9NZJ95
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)ADAM33 C20orf153 UNQ873/PRO1891Q9BZ115
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)DLG5 KIAA0583 PDLGQ8TDM65
Disrupted in renal carcinoma protein 1 (Disrupted in renal cancer protein)DIRC1Q969H95
DMWD protein (Dystrophia myotonica-containing WD repeat motif)DMWDQ8WUW65
DNA dC->dU-editing enzyme APOBEC-3H (EC 3.5.4.-) (APOBEC-related protein 10) (ARP-10) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H) (A3H)APOBEC3HQ6NTF75
DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)POLA2Q141815
DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B)RAD54BQ9Y6205
DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125)XPC XPCCQ018315
DNA repair protein complementing XP-G cells (EC 3.1.-.-) (DNA excision repair protein ERCC-5) (Xeroderma pigmentosum group G-complementing protein)ERCC5 ERCM2 XPG XPGCP287155
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)MCM6Q145665
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)TOP1P113875
DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)TOP2BQ028805
DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.99.1.2)TOP1MTQ969P65
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3)ID3 1R21 BHLHB25 HEIR1Q025355
DNA-binding protein RFXANK (Ankyrin repeat family A protein 1) (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein)RFXANK ANKRA1 RFXBO145935
DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53)POLR1E PAF53 PRAF1Q9GZS15
DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)POLR2IP369545
DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62)POLR3CQ9BUI45
DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)POLR3E KIAA1452Q9NVU05
DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)CRCPO755755
DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40)POLR1C POLR1EO151605
DnaJ homolog subfamily B member 5 (Heat shock protein Hsp40-2) (Heat shock protein Hsp40-3) (Heat shock protein cognate 40) (Hsc40)DNAJB5 HSC40O759535
DnaJ homolog subfamily C member 11DNAJC11Q9NVH15
DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)DNAJC7 TPR2 TTC2Q996155
DnaJ homolog subfamily C member 9 (DnaJ protein SB73)DNAJC9Q8WXX55
Dolichol phosphate-mannose biosynthesis regulatory proteinDPM2 My026O947775
Doublesex- and mab-3-related transcription factor C2DMRTC2Q8IXT25
Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)CLK4Q9HAZ15
Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3)DCTN6 WS3O003995
Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like 120 kDa protein, form S1]OPA1 KIAA0567O603135
Dynein light chain 4, axonemalDNAL4O960155
Dyslexia-associated protein KIAA0319-like proteinKIAA0319L KIAA1837 PP791Q8IZA05
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