EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]DAG1Q141185
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)EP400 CAGH32 KIAA1498 KIAA1818 TNRC12Q96L915
E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (Signal transduction protein CBL)CBL CBL2 RNF55P226815
E3 ubiquitin-protein ligase Hakai (EC 6.3.2.-) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (RING finger protein 188) (c-Cbl-like protein 1)CBLL1 HAKAI RNF188Q75N035
E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176)MARCH6 KIAA0597 RNF176 TEB4O603375
E3 ubiquitin-protein ligase MARCH8 (EC 6.3.2.-) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178)MARCH8 MIR RNF178Q5T0T05
E3 ubiquitin-protein ligase RNF144B (EC 6.3.2.-) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein)RNF144B IBRDC2 P53RFPQ7Z4195
E3 ubiquitin-protein ligase RNF4 (EC 6.3.2.-) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)RNF4 SNURF RES4-26P783175
E3 ubiquitin-protein ligase RNF5 (EC 6.3.2.-) (Protein G16) (RING finger protein 5) (Ram1 homolog) (HsRma1)RNF5 G16 NG2 RMA1Q999425
E3 ubiquitin-protein ligase RNF6 (EC 6.3.2.-)RNF6 SPG2Q9Y2525
E3 ubiquitin-protein ligase TRIM11 (EC 6.3.2.-) (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11)TRIM11 RNF92Q96F445
E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)UHRF1 ICBP90 NP95 RNF106Q96T885
E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP)XIAP API3 BIRC4 IAP3P981705
E3 ubiquitin-protein ligase ZFP91 (EC 6.3.2.-) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91)ZFP91 ZNF757 FKSG11Q96JP55
Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]ENOX2 COVA1Q162065
Ectodysplasin-A receptor-associated adapter protein (EDAR-associated death domain protein) (Protein crinkled homolog)EDARADDQ8WWZ35
EDN1 protein (Endothelin 1, isoform CRA_b) (cDNA FLJ75736, highly similar to Homo sapiens endothelin 1 (EDN1), mRNA)EDN1 hCG_37405Q6FH535
EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)EFEMP2 FBLN4 UNQ200/PRO226O959675
Elastin (Tropoelastin)ELNP155025
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32)ERGIC1 ERGIC32 KIAA1181 HT034Q969X55
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84)ERGIC3 C20orf47 ERV46 SDBCAG84 CGI-54 PRO0989Q9Y2825
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)EPS8L1 DRC3 EPS8R1 PP10566Q8TE685
Epidermal growth factor-like protein 8 (EGF-like protein 8) (Vascular endothelial statin-2) (VE-statin-2)EGFL8 C6orf8 NG3 UNQ8752/PRO29920Q999445
Epididymal secretory glutathione peroxidase (EC 1.11.1.9) (Epididymis-specific glutathione peroxidase-like protein) (EGLP) (Glutathione peroxidase 5) (GPx-5) (GSHPx-5)GPX5O757155
Epsilon-sarcoglycan (Epsilon-SG)SGCE ESG UNQ433/PRO840O435565
ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)ERRFI1 MIG6Q9UJM35
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924O949055
Erythroid differentiation-related factor 1EDRF1 C10orf137Q3B7T15
ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor)ETV3 METS PE1P411625
ETS translocation variant 3-like proteinETV3LQ6ZN325
ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)ELF3 ERT ESX JENP785455
Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18)EEF1E1 AIMP3 P18O433245
Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]EIF2A CDA02 MSTP004 MSTP089Q9BY445
Eukaryotic translation initiation factor 5BEIF5BQ8N5A05
Exocyst complex component 3-like protein 2 (HBV X-transactivated gene 7 protein) (HBV XAg-transactivated protein 7)EXOC3L2 XTP7Q2M3D25
Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)EXO1 EXOI HEX1Q9UQ845
Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8)EXOSC7 KIAA0116 RRP42Q150245
Exportin-4 (Exp4)XPO4 KIAA1721Q9C0E25
F-box only protein 17 (F-box only protein 26)FBXO17 FBG4 FBX17 FBX26 FBXO26Q96EF65
F-box only protein 24FBXO24 FBX24O754265
F-box only protein 31FBXO31 FBX14 FBX31 PP2386Q5XUX05
F-box only protein 33FBXO33 FBX33Q7Z6M25
F-box only protein 34FBXO34 FBX34Q9NWN35
F-box only protein 38 (Modulator of KLF7 activity homolog) (MoKA)FBXO38 SP329Q6PIJ65
F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3)FBXO44 FBG3 FBX30 FBX44 FBX6A FBXO6AQ9H4M35
F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)FBXO6 FBG2 FBS2 FBX6Q9NRD15
F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)FBXL14 FBL14Q8N1E65
F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16)FBXL16 C16orf22 FBL16Q8N4615
F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A)FBXL6 FBL6Q8N5315
F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35)FBXW12 FBW12 FBXO12 FBXO35Q6X9E45
Family with sequence similarity 57, member B, isoform CRA_b (Uncharacterized protein)FAM57B hCG_1770714F1T0F55
Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1)FEZ1Q996895
FGGY carbohydrate kinase domain-containing protein (EC 2.7.1.-)FGGYQ96C115
Fibroblast growth factor 11 (FGF-11) (Fibroblast growth factor homologous factor 3) (FHF-3)FGF11 FHF3Q929145
Fibronectin (Fragment)0Q9UQS65
Fibronectin type III domain-containing protein 4 (Fibronectin type III repeat-containing protein 1)FNDC4 FRCP1 UNQ6389/PRO21134Q9H6D85
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)FLNA FLN FLN1P213335
Folliculin-interacting protein 1FNIP1 KIAA1961Q8TF405
Forkhead box protein E3 (Forkhead-related protein FKHL12) (Forkhead-related transcription factor 8) (FREAC-8)FOXE3 FKHL12 FREAC8Q134615
Forkhead box protein K1 (Myocyte nuclear factor) (MNF)FOXK1 MNFP850375
Forkhead box protein P1FOXP1 HSPC215Q9H3345
Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1)FNBP1L C1orf39 TOCA1Q5T0N55
Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)FMNL3 FHOD3 KIAA2014 WBP3Q8IVF75
Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)FURIN FUR PACE PCSK3P099585
FXYD domain-containing ion transport regulator 6 (Phosphohippolin)FXYD6 UNQ521/PRO1056Q9H0Q35
FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)FGD1 FGDY ZFYVE3P981745
FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)FGD2 ZFYVE4Q7Z6J45
FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)FGD3 ZFYVE5Q5JSP05
G-protein-signaling modulator 1 (Activator of G-protein signaling 3)GPSM1 AGS3Q86YR55
G-protein-signaling modulator 2 (Mosaic protein LGN)GPSM2 LGNP812745
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG)TDGQ135695
G1/S-specific cyclin-E2CCNE2O960205
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)GABARAP FLC3B HT004O951665
Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)GABBR1 GPRC3AQ9UBS55
Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)GGHQ928205
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)PSENEN PEN2 MDS033Q9NZ425
Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98)TUBGCP3 GCP3Q96CW55
Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein)GJC2 GJA12Q5T4425
GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2)GFRA2 GDNFRB RETL2 TRNR2O004515
GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)GFRA3 UNQ339/PRO538/PRO3664O606095
GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2)POFUT2 C21orf80 FUT13 KIAA0958Q9Y2G55
Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1)GEMIN2 SIP1O148935
General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein)GRASPQ7Z6J25
General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma)GTF3C3Q9Y5Q95
General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein)GTF2IRD1 CREAM1 GTF3 MUSTRD1 RBAP2 WBSCR11 WBSCR12Q9UHL95
Germ cell-less protein-like 1GMCL1 GCLQ96IK55
Glucocorticoid nuclear receptor variant 1NR3C1F1D8N45
Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D)GCKP355575
Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform)GAD1 GAD GAD67Q992595
Glutamate-rich protein 1ERICH1 HSPC319Q86X535
Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase)GLS GLS1 KIAA0838O949255
Glutamine synthetase (EC 6.3.1.2)PIG59 GLUL hCG_24393A8YXX45
Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5) (Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC)QPCTLQ9NXS25
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2)GATC 15E1.2O437165
Glutaredoxin-2, mitochondrialGLRX2 GRX2 CGI-133Q9NS185
Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)GPX3 GPXPP223525
Glutathione S-transferase A1 (EC 2.5.1.18) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed]GSTA1P082635
Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4)GSTM4Q030135
Glycine cleavage system H protein, mitochondrialGCSHP234345
Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Protein FAM20B) (Xylose kinase)FAM20B KIAA0475O750635
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