| Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) | ALAD | P13716 | 4 |
| DENN domain-containing protein 2D | DENND2D | Q9H6A0 | 4 |
| DENN domain-containing protein 4C | DENND4C C9orf55 C9orf55B | Q5VZ89 | 4 |
| Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | DTL CDT2 CDW1 DCAF2 L2DTL RAMP | Q9NZJ0 | 4 |
| Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) (Muscle-specific DNase I-like) (XIB) | DNASE1L1 DNAS1L1 DNL1L | P49184 | 4 |
| Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1) | DERL1 DER1 UNQ243/PRO276 | Q9BUN8 | 4 |
| Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP) | DPT | Q07507 | 4 |
| Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | DGKD KIAA0145 | Q16760 | 4 |
| Digestive organ expansion factor homolog | DIEXF C1orf107 DEF | Q68CQ4 | 4 |
| Dihydrofolate reductase (EC 1.5.1.3) (cDNA, FLJ93028, Homo sapiens dihydrofolate reductase (DHFR), mRNA) | DYR DHFR | B0YJ76 | 4 |
| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | DLAT DLTA | P10515 | 4 |
| Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC 1.14.13.8) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1) | FMO1 | Q01740 | 4 |
| Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | DPP3 | Q9NY33 | 4 |
| Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) | DPP8 DPRP1 MSTP097 MSTP135 MSTP141 | Q6V1X1 | 4 |
| DIS3-like exonuclease 1 (EC 3.1.13.-) | DIS3L DIS3L1 KIAA1955 | Q8TF46 | 4 |
| Disco-interacting protein 2 homolog C (DIP2 homolog C) | DIP2C KIAA0934 | Q9Y2E4 | 4 |
| Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein) | DCBLD2 CLCP1 ESDN | Q96PD2 | 4 |
| Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | ADAM17 CSVP TACE | P78536 | 4 |
| Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | DLG4 PSD95 | P78352 | 4 |
| DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) | DDB2 | Q92466 | 4 |
| DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) | DDIT3 CHOP CHOP10 GADD153 | P35638 | 4 |
| DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.-) (Phorbolin-1) | APOBEC3A | P31941 | 4 |
| DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.-) (Phorbolin-1-related protein) (Phorbolin-2/3) | APOBEC3B | Q9UH17 | 4 |
| DNA helicase INO80 (hINO80) (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1) | INO80 INO80A INOC1 KIAA1259 | Q9ULG1 | 4 |
| DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | LIG1 | P18858 | 4 |
| DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) | POLD4 POLDS | Q9HCU8 | 4 |
| DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | POLE3 CHRAC17 | Q9NRF9 | 4 |
| DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | POLH RAD30 RAD30A XPV | Q9Y253 | 4 |
| DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) | POLK DINB1 | Q9UBT6 | 4 |
| DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | MCM4 CDC21 | P33991 | 4 |
| DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11) | POLR3K RPC11 My010 | Q9Y2Y1 | 4 |
| DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) | POLR3B | Q9NW08 | 4 |
| DnaJ homolog subfamily B member 12 | DNAJB12 | Q9NXW2 | 4 |
| DnaJ homolog subfamily B member 2 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) | DNAJB2 HSJ1 HSPF3 | P25686 | 4 |
| DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ) | DNAJC15 DNAJD1 GIG22 HSD18 | Q9Y5T4 | 4 |
| Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK1 | Q99704 | 4 |
| Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC) | STT3A ITM1 TMC | P46977 | 4 |
| DPY30 domain-containing protein 2 | DYDC2 | Q96IM9 | 4 |
| Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin) | DRAXIN C1orf187 PSEC0258 UNQ3119/PRO10268 | Q8NBI3 | 4 |
| Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 | P45985 | 4 |
| Dual specificity phosphatase 28 (EC 3.1.3.16) (EC 3.1.3.48) | DUSP28 | Q4G0W2 | 4 |
| Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | CLK2 | P49760 | 4 |
| Dual specificity protein phosphatase 13 isoform A (DUSP13A) (EC 3.1.3.16) (EC 3.1.3.48) (Branching-enzyme interacting DSP) (Muscle-restricted DSP) (MDSP) | DUSP13 BEDP DUSP13A MDSP | Q6B8I1 | 4 |
| Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) | CDC14A | Q9UNH5 | 4 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) | DYRK3 | O43781 | 4 |
| Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) | DNAH2 DNAHC2 DNHD3 KIAA1503 | Q9P225 | 4 |
| Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b) | DNAH3 DNAHC3B | Q8TD57 | 4 |
| E3 SUMO-protein ligase PIAS1 (EC 6.3.2.-) (DEAD/H box-binding protein 1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | PIAS1 DDXBP1 | O75925 | 4 |
| E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | RANBP2 NUP358 | P49792 | 4 |
| E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 6.3.2.-) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) | RNF40 BRE1B KIAA0661 | O75150 | 4 |
| E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | CBLB RNF56 Nbla00127 | Q13191 | 4 |
| E3 ubiquitin-protein ligase MARCH3 (EC 6.3.2.-) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) | MARCH3 RNF173 | Q86UD3 | 4 |
| E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1) | MIB2 SKD ZZANK1 | Q96AX9 | 4 |
| E3 ubiquitin-protein ligase rififylin (EC 6.3.2.-) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) | RFFL RNF189 RNF34L | Q8WZ73 | 4 |
| E3 ubiquitin-protein ligase RNF125 (EC 6.3.2.-) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1) | RNF125 | Q96EQ8 | 4 |
| E3 ubiquitin-protein ligase RNF135 (EC 6.3.2.-) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (Riplet) | RNF135 L13 | Q8IUD6 | 4 |
| E3 ubiquitin-protein ligase RNF185 (EC 6.3.2.-) (RING finger protein 185) | RNF185 | Q96GF1 | 4 |
| E3 ubiquitin-protein ligase RNF19A (EC 6.3.2.-) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | RNF19A RNF19 | Q9NV58 | 4 |
| E3 ubiquitin-protein ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | TOPORS LUN TP53BPL | Q9NS56 | 4 |
| E3 ubiquitin-protein ligase TRIM41 (EC 6.3.2.-) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41) | TRIM41 RINCK | Q8WV44 | 4 |
| E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) | TRIM56 RNF109 | Q9BRZ2 | 4 |
| E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.19) (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | TRIM25 EFP RNF147 ZNF147 | Q14258 | 4 |
| Early growth response protein 3 (EGR-3) (Zinc finger protein pilot) | EGR3 PILOT | Q06889 | 4 |
| Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) | EML1 EMAP1 EMAPL EMAPL1 | O00423 | 4 |
| Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase 2) (EC 3.6.1.-) (CD39 antigen-like 1) (Ecto-ATP diphosphohydrolase 2) (Ecto-ATPDase 2) (Ecto-ATPase 2) | ENTPD2 CD39L1 | Q9Y5L3 | 4 |
| EF-hand calcium-binding domain-containing protein 11 | EFCAB11 C14orf143 | Q9BUY7 | 4 |
| ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | ERC1 ELKS KIAA1081 RAB6IP2 | Q8IUD2 | 4 |
| Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | EEF1A2 EEF1AL STN | Q05639 | 4 |
| Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1) | ELP2 STATIP1 | Q6IA86 | 4 |
| Elongator complex protein 3 (hELP3) (EC 2.3.1.48) | ELP3 | Q9H9T3 | 4 |
| Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3) | EFS CASS3 | O43281 | 4 |
| Endonuclease III-like protein 1 (EC 4.2.99.18) | NTHL1 NTH1 OCTS3 | P78549 | 4 |
| Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | SH3GL1 CNSA1 SH3D2B | Q99961 | 4 |
| Endoplasmic reticulum-Golgi intermediate compartment protein 2 | ERGIC2 ERV41 PTX1 CDA14 | Q96RQ1 | 4 |
| Endothelial transcription factor GATA-2 (GATA-binding protein 2) | GATA2 | P23769 | 4 |
| Engulfment and cell motility protein 1 (Protein ced-12 homolog) | ELMO1 KIAA0281 | Q92556 | 4 |
| Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | ELMO2 CED12A KIAA1834 | Q96JJ3 | 4 |
| Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | NEDD9 CASL CASS2 | Q14511 | 4 |
| Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog) | ENOPH1 MASA MSTP145 | Q9UHY7 | 4 |
| Enoyl-CoA delta isomerase 2, mitochondrial (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1) | ECI2 DRS1 HCA88 PECI | O75521 | 4 |
| EP300 protein (Fragment) | EP300 | Q7Z6C1 | 4 |
| Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) | NGEF | Q8N5V2 | 4 |
| Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | EPHA8 EEK HEK3 KIAA1459 | P29322 | 4 |
| Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | EPHB4 HTK MYK1 TYRO11 | P54760 | 4 |
| Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6) | EPHB6 | O15197 | 4 |
| Epidermal growth factor receptor kinase substrate 8 | EPS8 | Q12929 | 4 |
| Epididymis luminal secretory protein 52 | EL52 | K9JA46 | 4 |
| Epididymis tissue sperm binding protein Li 3a | 0 | E9KL35 | 4 |
| Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326) | EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 | P16422 | 4 |
| Epithelial membrane protein 1 (EMP-1) (CL-20) (Protein B4B) (Tumor-associated membrane protein) | EMP1 B4B TMP | P54849 | 4 |
| Epithelial membrane protein 2 (EMP-2) (Protein XMP) | EMP2 XMP | P54851 | 4 |
| Epithelial membrane protein 3 (EMP-3) (Hematopoietic neural membrane protein 1) (HNMP-1) (Protein YMP) | EMP3 YMP | P54852 | 4 |
| ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85) | EMC4 TMEM85 HSPC184 PIG17 | Q5J8M3 | 4 |
| Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | ESR1 ESR NR3A1 | P03372 | 4 |
| ETS-related transcription factor Elf-5 (E74-like factor 5) (Epithelium-restricted ESE-1-related Ets factor) (Epithelium-specific Ets transcription factor 2) (ESE-2) | ELF5 ESE2 | Q9UKW6 | 4 |
| Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | EEF2K | O00418 | 4 |
| Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) | EIF1AY | O14602 | 4 |
| EVI5-like protein (Ecotropic viral integration site 5-like protein) | EVI5L | Q96CN4 | 4 |
| Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC) | ECSIT | Q9BQ95 | 4 |
| Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) | EXOC6 SEC15A SEC15L SEC15L1 | Q8TAG9 | 4 |