EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Histone H2B type 1-O (Histone H2B.2) (Histone H2B.n) (H2B/n)HIST1H2BO H2BFH H2BFNP235274
Histone H2B type 3-B (H2B type 12)HIST3H2BBQ8N2574
Histone RNA hairpin-binding protein (Histone stem-loop-binding protein)SLBP HBPQ144934
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)RBBP7 RBAP46Q165764
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)EZH2 KMT6Q159104
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)SETDB1 KIAA0067 KMT1EQ150474
Histone-lysine N-methyltransferase SUV420H1 (EC 2.1.1.43) (Lysine N-methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1)SUV420H1 KMT5B CGI-85Q4FZB74
HLA class I histocompatibility antigen, A-2 alpha chain (MHC class I antigen A*2)HLA-A HLAAP018924
HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74)CD74 DHLAGP042334
HLA class II histocompatibility antigen, DO beta chain (MHC class II antigen DOB)HLA-DOBP137654
HLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)HLA-DPA1 HLA-DP1A HLASBP200364
HNRNPL protein (Fragment)HNRNPLQ6NTA24
Homeobox protein aristaless-like 3 (Proline-rich transcription factor ALX3)ALX3O950764
Homeobox protein engrailed-2 (Homeobox protein en-2) (Hu-En-2)EN2P196224
Homeobox protein Hox-A5 (Homeobox protein Hox-1C)HOXA5 HOX1CP207194
Homeobox protein Hox-A9 (Homeobox protein Hox-1G)HOXA9 HOX1GP312694
Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1)HOXB5 HOX2AP090674
Homeobox protein Hox-B6 (Homeobox protein Hox-2.2) (Homeobox protein Hox-2B) (Homeobox protein Hu-2)HOXB6 HOX2BP175094
Homeobox protein Hox-D4 (Homeobox protein HHO.C13) (Homeobox protein Hox-4B) (Homeobox protein Hox-5.1)HOXD4 HOX4BP090164
Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein)MSX1 HOX7P283604
Homeobox protein Nkx-2.3 (Homeobox protein NK-2 homolog C)NKX2-3 NKX23 NKX2CQ8TAU04
Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)HIPK2Q9H2X64
Hormone-sensitive lipase (HSL) (EC 3.1.1.79)LIPEQ054694
HSPC1930Q9P0T04
Huntingtin-interacting protein K (Huntingtin yeast partner K)HYPK C15orf63 HSPC136Q9NX554
Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein)HAPLN1 CRTL1P109154
Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Lung carcinoma protein 1) (LuCa-1)HYAL1 LUCA1Q127944
Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29)HIC1 ZBTB29Q145264
ICOS ligand (Inducible T-cell co-stimulator ligand, isoform CRA_a) (cDNA FLJ33173 fis, clone ADRGL2002191, highly similar to ICOS ligand)ICOSLG hCG_401312A8MUZ14
Immunoglobulin superfamily member 21 (IgSF21)IGSF21Q96ID54
Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog)PAMR1 RAMP FP938 UNQ699/PRO1344Q6UXH94
Inhibin beta C chain (Activin beta-C chain)INHBCP551034
Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.19) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p)ITPA C20orf37 My049 OK/SW-cl.9Q9BY324
Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2)IMPA2 IMP.18PO147324
Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57)INPP1P494414
Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein)OCRL INPP5F OCRL1Q019684
Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]INSL3 RLF RLNLP514604
Insulin-like growth factor binding protein, acid labile subunitIGFALSQ8TAY04
Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2)IGFBP2 BP2 IBP2P180654
Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)IGFBP3 IBP3P179364
Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF)IGFBP7 MAC25 PSFQ162704
Integrator complex subunit 1 (Int1)INTS1 KIAA1440 UNQ1821/PRO3434Q8N2014
Integrator complex subunit 7 (Int7)INTS7 C1orf73Q9NVH24
Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74)INTS9 RC74Q9NV884
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)ITGB2 CD18 MFI7P051074
Inter-alpha-trypsin inhibitor heavy chain H6 (Inter-alpha-trypsin inhibitor heavy chain H5-like protein) (Inter-alpha inhibitor H5-like protein)ITIH6 ITIH5L UNQ6369/PRO21074Q6UXX54
Interferon alpha-4 (IFN-alpha-4) (Interferon alpha-4B) (Interferon alpha-76) (Interferon alpha-M1)IFNA4P050144
Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)IFNAR2 IFNABR IFNARBP485514
Interferon regulatory factor 5 (IRF-5)IRF5Q135684
Interferon regulatory factor 7 (IRF-7)IRF7Q929854
Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)IRF9 ISGF3GQ009784
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58)IFIT5 ISG58 RI58Q133254
Interferon-inducible protein AIM2 (Absent in melanoma 2)AIM2O148624
Interleukin 4 (Interleukin 4, isoform CRA_a)IL4 hCG_24113D4HNR64
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)IL1RAP C3orf13 IL1R3Q9NPH34
Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA)IL11RAQ146264
Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]IL15RAQ132614
Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE)IL17RE UNQ3056/PRO9877Q8NFR94
Interleukin-17D (IL-17D) (Interleukin-27) (IL-27)IL17D IL27 UNQ3096/PRO21175Q8TAD24
Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)IL18BPO959984
Interleukin-24 (IL-24) (Melanoma differentiation-associated gene 7 protein) (MDA-7) (Suppression of tumorigenicity 16 protein)IL24 MDA7 ST16Q130074
Interleukin-36 receptor antagonist protein (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)IL36RN FIL1D IL1F5 IL1HY1 IL1L1 IL1RP3 UNQ1896/PRO4342Q9UBH04
Intermediate filament family orphan 1 (Tumor antigen HOM-TES-103)IFFO1 IFFOQ0D2I54
Intraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4)IFT27 RABL4 RAYLQ9BW834
Intraflagellar transport protein 43 homologIFT43 C14orf179Q96FT94
Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56)IFT80 KIAA1374 WDR56Q9P2H34
Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160)AQR KIAA0560O603064
IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ)IQCB1 KIAA0036 NPHP5 OK/SW-cl.85Q150514
IQ domain-containing protein CIQCCQ4KMZ14
IQ motif and SEC7 domain-containing protein 2IQSEC2 KIAA0522Q5JU854
Iron-sulfur protein NUBPL (IND1 homolog) (Nucleotide-binding protein-like) (huInd1)NUBPL C14orf127Q8TB374
Iroquois-class homeodomain protein IRX-4 variant 1 (Iroquois-class homeodomain protein IRX-4 variant 3)IRX4H1AFL04
JM11 protein, isoform CRA_a (cDNA FLJ76847, highly similar to Homo sapiens JM11 protein (JM11), mRNA) (cDNA, FLJ79486, weakly similar to FERM domain-containing protein 4B)JM11 hCG_1749782A8K5Q54
Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)JOSD1 JSPH1 KIAA0063Q150404
Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1)AMICA1 JAML UNQ722/PRO1387Q86YT94
Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45)JSRP1 JP45Q96MG24
Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6)KLK14 KLKL6Q9P0G34
Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)KLK2P201514
Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)KLK8 NRPN PRSS19 TADG14 UNQ283/PRO322O602594
KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)KANSL2 C12orf41 NSL2Q9H9L44
Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 3.6.4.3) (p60 katanin)KATNA1O754494
Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)KLHDC2 HCA33Q9Y2U94
Kelch domain-containing protein 4KLHDC4Q8TBB54
Kelch domain-containing protein 7AKLHDC7AQ5VTJ34
Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B)KBTBD11 CMLAP KIAA0711 KLHDC7CO948194
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)KLHL12 C3IP1Q53G594
Kelch-like protein 3KLHL3 KIAA1129Q9UH774
Keratin, type I cytoskeletal 13 (Cytokeratin-13) (CK-13) (Keratin-13) (K13)KRT13P136464
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)KRT1 KRTAP042644
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)KRT5P136474
Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10)KRT6B K6B KRTL1P042594
Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)KRT71 K6IRS1 KB34 KRT6IRS1Q3SY844
Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-6-like) (Keratin-6L) (Keratin-79) (K79) (Type-II keratin Kb38)KRT79 K6L KB38 KRT6LQ5XKE54
Keratin-associated protein 12-1 (High sulfur keratin-associated protein 12.1) (Keratin-associated protein 12.1)KRTAP12-1 KAP12.1 KRTAP12.1P599904
Keratin-associated protein 19-1 (High tyrosine-glycine keratin-associated protein 19.1)KRTAP19-1 KAP19.1 KRTAP19.1Q8IUB94
Keratin-associated protein 5-10 (Keratin-associated protein 5.10) (Ultrahigh sulfur keratin-associated protein 5.10)KRTAP5-10 KAP5.10 KRTAP5.10Q6L8G54
Keratin-associated protein 5-2 (Keratin-associated protein 5-8) (Keratin-associated protein 5.2) (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.2)KRTAP5-2 KAP5-8 KAP5.2 KRTAP5-8 KRTAP5.2 KRTAP5.8Q701N44
Keratin-associated protein 5-5 (Keratin-associated protein 5-11) (Keratin-associated protein 5.11) (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5)KRTAP5-5 KAP5-11 KAP5.5 KRTAP5-11 KRTAP5.11 KRTAP5.5Q701N24
Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2)KRTAP9-2 KAP9.2 KRTAP9.2Q9BYQ44
Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K) (MHC class I NK cell receptor) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (p70 NK receptor CL-5) (CD antigen CD158k)KIR3DL2 CD158K NKAT4P436304
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