EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.-)MSRB3 UNQ1965/PRO4487Q8IXL74
Methyl-CpG binding domain protein 6MBD6Q6P0P04
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)MCCC1 MCCAQ96RQ34
Methylenetetrahydrofolate reductase (EC 1.5.1.20)MTHFRP428984
Methylmalonic aciduria and homocystinuria type C proteinMMACHCQ9Y4U14
Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)MCEEQ96PE74
Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50)WDR77 MEP50 HKMT1069 Nbla10071Q9BQA14
Methyltransferase-like protein 7B (EC 2.1.1.-)METTL7B UNQ594/PRO1180Q6UX534
MFS-type transporter SLC18B1 (Solute carrier family 18 member B1)SLC18B1 C6orf192Q6NT164
MHC class I polypeptide-related sequence B (MIC-B)MICB PERB11.2Q299804
MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1)RFX1P226704
Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Microsomal GST-II)MGST2 GST2Q997354
Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)MAPRE2 RP1Q155554
Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1Q9ULD24
Midnolin (Midbrain nucleolar protein)MIDNQ504T84
Mimitin, mitochondrial (B17.2-like) (B17.2L) (Myc-induced mitochondrial protein) (MMTN) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2) (NDUFA12-like protein)NDUFAF2 NDUFA12LQ8N1834
Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2)PMS2 PMSL2P542784
Mitochondrial assembly of ribosomal large subunit protein 1MALSU1 C7orf30Q96EH34
Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)FIS1 TTC11 CGI-135Q9Y3D64
Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)SLC25A22 GC1Q9H9364
Mitochondrial import inner membrane translocase subunit Tim23TIMM23 TIM23O149254
Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein)TIMM8A DDP DDP1 TIM8AO602204
Mitochondrial import inner membrane translocase subunit Tim9TIMM9 TIM9 TIM9A TIMM9AQ9Y5J74
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit)TOMM70A KIAA0719 TOM70O948264
Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) (Ku70-binding protein 3) (XRCC6-binding protein 1)XRCC6BP1 KUB3Q9Y6H34
Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4)CHCHD4 MIA40Q8N4Q14
Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR)MSRAQ9UJ684
Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)RHOT1 ARHT1Q8IXI24
Mitochondrial ribonuclease P protein 3 (Mitochondrial RNase P protein 3)KIAA0391 MRPP3O150914
Mitochondrial-processing peptidase subunit alpha (EC 3.4.24.64) (Alpha-MPP) (P-55)PMPCA INPP5E KIAA0123 MPPAQ107134
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2AQ165394
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)MAP3K3 MAPKKK3 MEKK3Q997594
Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)BUB1 BUB1LO436834
Mixed lineage kinase domain-like proteinMLKLQ8NB164
MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)MKI67IP NIFK NOPP34Q9BYG34
Monocyte to macrophage differentiation factor (Progestin and adipoQ receptor family member 11) (Progestin and adipoQ receptor family member XI)MMD PAQR11Q155464
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)SMAD1 BSP1 MADH1 MADR1Q157974
MPN domain-containing protein (EC 3.4.-.-)MPNDQ8N5944
MTSS1-like protein (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1)MTSS1LQ765P74
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1)MADCAM1Q134774
Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11)ABCC5 MRP5O154404
Multiple C2 and transmembrane domain-containing protein 1MCTP1Q6DN144
Multiple C2 and transmembrane domain-containing protein 2MCTP2Q6DN124
Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)MCFD2 SDNSFQ8NI224
Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3)MEGF6 EGFL3 KIAA0815O750954
Multiple PDZ domain protein (Multi-PDZ domain protein 1)MPDZ MUPP1O759704
Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)MVB12A CFBP FAM125AQ96EY54
Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)MVB12B C9orf28 FAM125BQ9H7P64
Mutated cytochrome P-450c11 protein0Q8TDD04
Myb/SANT-like DNA-binding domain-containing protein 1MSANTD1 C4orf44Q6ZTZ14
Myelin P2 protein (Peripheral myelin protein 2)PMP2P026894
Myelin proteolipid protein (PLP) (Lipophilin)PLP1 PLPP602014
Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]MYRF C11orf9 KIAA0954 MRFQ9Y2G14
Myeloid differentiation primary response protein MyD88MYD88Q998364
Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42)MZF1 MZF ZNF42 ZSCAN6P286984
Myeloma-overexpressed gene protein (Oncogene in multiple myeloma)MYEOV OCIMQ96EZ44
Myocyte-specific enhancer factor 2CMEF2CQ064134
Myomesin-3 (Myomesin family member 3)MYOM3Q5VTT54
Myotubularin (EC 3.1.3.64)MTM1 CG2Q134964
Myotubularin-related protein 6 (EC 3.1.3.-)MTMR6Q9Y2174
N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2)GALK2 GK2Q014154
N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S)GNSP155864
N-acetyltransferase 10 (EC 2.3.1.-)NAT10 ALP KIAA1709Q9H0A04
N-acetyltransferase 9 (EC 2.3.1.-) (Embryo brain-specific protein)NAT9 EBSQ9BTE04
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]OGG1 MMH MUTM OGH1O155274
N-myc (And STAT) interactorNMIQ8WTW24
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)SIRT3 SIR2L3Q9NTG74
NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, 3, 9kDa, isoform CRA_e (NDUFA3 protein) (cDNA FLJ76508, highly similar to Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa (NDUFA3), mRNA)NDUFA3 hCG_20947Q6FGG44
NADH dehydrogenase (Ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) (NADH dehydrogenase (Ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase), isoform CRA_a) (NDUFS5 protein) (cDNA, FLJ92475, Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa(NADH-coenzyme Q reductase) (NDUFS5), mRNA)NDUFS5 hCG_1782706Q6IBA04
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7)NDUFA11Q86Y394
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit)NDUFA3O951674
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit)NDUFA4O004834
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Complex I-PDSW) (CI-PDSW) (NADH-ubiquinone oxidoreductase PDSW subunit)NDUFB10O960004
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit)NDUFB2O951784
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (LYR motif-containing protein 3) (NADH-ubiquinone oxidoreductase B22 subunit)NDUFB9 LYRM3 UQOR22Q9Y6M94
NADH dehydrogenase [ubiquinone] 1 subunit C2 (Complex I-B14.5b) (CI-B14.5b) (Human lung cancer oncogene 1 protein) (HLC-1) (NADH-ubiquinone oxidoreductase subunit B14.5b)NDUFC2 HLC1O952984
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-75kD) (CI-75kD)NDUFS1P283314
NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase)NOX4 RENOXQ9NPH54
Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C)NRD1O438474
Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2)SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20P492814
NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)NDFIP2 KIAA1165 N4WBP5AQ9NV924
NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)UBA3 UBE1CQ8TBC44
Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)NELFA WHSC2 P/OKcl.15Q9H3P24
Nesprin-4 (Nuclear envelope spectrin repeat protein 4)SYNE4 C19orf46Q8N2054
Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha)NRXN2 KIAA0921Q9P2S24
Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]NF1P213594
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]NOTCH3Q9UM474
Neuroligin-2NLGN2 KIAA1366Q8NFZ44
Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46)GAP43P176774
Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2Q8IVL14
Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)NPAS2 BHLHE9 MOP4 PASD4Q997434
Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (SATT) (Solute carrier family 1 member 4)SLC1A4 ASCT1 SATTP430074
Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox)NCF4 SH3PXD4Q150804
Neutrophil defensin 1 (Defensin, alpha 1) (HNP-1) (HP-1) (HP1) [Cleaved into: HP 1-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]DEFA1 DEF1 DEFA2 MRS; DEFA1BP596654
NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)NFKBIZ IKBZ INAP MAILQ9BYH84
Nicotinamide riboside kinase 2 (NRK 2) (NmR-K 2) (EC 2.7.1.22) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kinase 2)NMRK2 ITGB1BP3 NRK2Q9NPI54
Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1)NAPRT1 FHIPQ6XQN64
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)NISCH IRAS KIAA0975Q9Y2I14
NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) [Includes: Putative peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Rotamase)]NKTRP304144
NMDA receptor-regulated protein 2NARG2 BRCC1 UNQ3101/PRO10100Q659A14
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