EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Sperm surface protein Sp17 (Cancer/testis antigen 22) (CT22) (Sp17-1) (Sperm autoantigenic protein 17) (Sperm protein 17)SPA17 SP17Q155064
Sperm-associated antigen 11A (Human epididymis-specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2)SPAG11A EP2 HE2Q6PDA74
Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1) (Ki-ras-induced actin-interacting protein)SSFA2 CS1 KIAA1927 KRAPP282904
Spermatid perinuclear RNA-binding proteinSTRBP SPNRQ96SI94
Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411)SPATA20Q8TB224
Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 (EC 1.-.-.-) (EC 1.14.-.-) (Degenerative spermatocyte homolog 2)DEGS2 C14orf66Q6QHC54
Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)S1PR5 EDG8Q9H2284
Spindle and kinetochore-associated protein 2 (Protein FAM33A)SKA2 FAM33AQ8WVK74
Spindlin-4SPIN4Q56A734
Spliceosome-associated protein CWC15 homologCWC15 C11orf5 AD-002 HSPC148Q9P0134
Splicing factor, arginine/serine-rich 19 (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)SCAF1 SFRS19 SRA1Q9H7N44
SPRY domain-containing protein 4SPRYD4Q8WW594
SS18-like protein 2 (SYT homolog 2)SS18L2Q9UHA24
StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5)STARD5Q9NSY24
STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)STK39 SPAKQ9UEW84
StereocilinSTRCQ7RTU94
StriatinSTRNO438154
Stromal membrane-associated protein 1SMAP1Q8IYB54
Succinate dehydrogenase assembly factor 1, mitochondrial (SDH assembly factor 1) (LYR motif-containing protein 8)SDHAF1A6NFY74
Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (Succinate dehydrogenase subunit 5, mitochondrial) (hSDH5)SDHAF2 C11orf79 PGL2 SDH5Q9NX184
Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13)C7orf10 DERP13Q9HAC74
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Renal carcinoma antigen NY-REN-39) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)SUCLA2Q9P2R74
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)OXCT1 OXCT SCOTP558094
Sulfatase-modifying factor 2 (C-alpha-formylglycine-generating enzyme 2)SUMF2 PSEC0171 UNQ1968/PRO4500Q8NBJ74
Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)SOCS5 CIS6 CISH5 CISH6 KIAA0671O751594
Surfeit locus protein 4SURF4 SURF-4O152604
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)SMARCAD1 KIAA1122Q9H4L74
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1)SMARCAL1 HARPQ9NZC94
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C)SMARCD3 BAF60CQ6STE54
Synaptogyrin-1SYNGR1O437594
Synaptonemal complex protein 1 (SCP-1) (Cancer/testis antigen 8) (CT8)SYCP1 SCP1Q154314
Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)SYNRG AP1GBP1 SYNGQ9UMZ24
Syntaxin-4 (Renal carcinoma antigen NY-REN-31)STX4 STX4AQ128464
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)STXBP1 UNC18AP617644
Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)STXBP3O001864
T-box transcription factor TBX2 (T-box protein 2)TBX2Q132074
T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)TAL1 BHLHA17 SCL TCL5P175424
T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1)TIAM1Q130094
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta)TAF5L PAF65BO755294
Tail-anchored protein insertion receptor WRB (Congenital heart disease 5 protein) (Tryptophan-rich basic protein) (WRB)WRB CHD5O002584
TalaninZNF365 KIAA0844Q70YC44
TAR DNA binding protein, isoform CRA_cTARDBP hCG_2005583Q9H2564
TAR DNA-binding protein 43 (TDP-43)TARDBP TDP43Q131484
TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C)TAF1CQ155724
TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D)TAF1D JOSD3Q9H5J84
TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172)BTAF1 TAF172O149814
TCF3 fusion partner (INO80 complex subunit F) (Protein FB1)TFPT INO80FP0C1Z64
TELO2-interacting protein 2TTI2 C8orf41Q6NXR44
Tensin-3 (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)TNS3 TEM6 TENS1 TPPQ68CZ24
TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2)TINF2 TIN2Q9BSI44
Testican-1 (Protein SPOCK)SPOCK1 SPOCK TIC1 TICN1Q086294
Testin (TESS)TESQ9UGI84
Testis, prostate and placenta-expressed proteinTEPPQ6URK84
Testis-expressed sequence 10 proteinTEX10 L18 Nbla10363Q9NXF14
Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8)TTC23 HCC8Q5W5X94
Tetratricopeptide repeat protein 39C (TPR repeat protein 39C)TTC39C C18orf17Q8N5844
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)TGFBR2P371734
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)TAB3 MAP3K7IP3Q8N5C84
THAP domain-containing protein 11THAP11 HRIHFB2206Q96EK44
ThioredoxinTXNH9ZYJ24
Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19)TXNDC12 TLP19 UNQ713/PRO1376O958814
Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD)TXNL4A DIM1 TXNL4P838764
Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13)TMX4 KIAA1162 TXNDC13 PSEC0095 UNQ475/PRO938Q9H1E54
THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)THOC1 HPR1Q96FV94
THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)THOC6 WDR58 PSEC0006Q86W424
THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)THOC7 NIF3L1BP1Q6I9Y24
TOM1-like protein 2 (Target of Myb-like protein 2)TOM1L2Q6ZVM74
Trafficking protein particle complex subunit 6BTRAPPC6BQ86SZ24
Trans-Golgi network integral membrane protein 2 (TGN38 homolog) (TGN46) (TGN48) (Trans-Golgi network protein TGN51)TGOLN2 TGN46 TGN51O434934
Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h)TCEA3 TFIISHO757644
Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1)TFAP2CQ927544
Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33)TFE3 BHLHE33P195324
Transcription factor HES-7 (hHes7) (Class B basic helix-loop-helix protein 37) (bHLHb37) (Hairy and enhancer of split 7) (bHLH factor Hes7)HES7 BHLHB37Q9BYE04
Transcription factor Sp5SP5Q6BEB44
Transcription factor Sp7 (Zinc finger protein osterix)SP7 OSXQ8TDD24
Transcription factor SPT20 homolog (p38-interacting protein) (p38IP)SUPT20H C13orf19 FAM48A FP757Q8NEM74
Transcription initiation factor IIB (General transcription factor TFIIB) (S300-II)GTF2B TF2B TFIIBQ004034
Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18)TAF13 TAF2K TAFII18Q155434
Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2)TTF2Q9UNY44
Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B)PURBQ96QR84
Transducin-like enhancer of split 3 splice variant 2TLE3Q6PRX24
Transforming growth factor beta-3 (TGF-beta-3) [Cleaved into: Latency-associated peptide (LAP)]TGFB3P106004
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP)TGFBI BIGH3Q155824
Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)TAGLN SM22 WS3-10Q019954
Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)TRPM4 LTRPC4Q8TD434
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)VCPP550724
Transmembrane and coiled-coil domain-containing protein 1 (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3)TMCO1 TMCC4 PNAS-10 PNAS-136 UNQ151/PRO177Q9UM004
Transmembrane and immunoglobulin domain-containing protein 2 (Immunoglobulin and proline-rich receptor 1) (IGPR-1)TMIGD2 IGPR1 UNQ3059/PRO9879Q96BF34
Transmembrane and ubiquitin-like domain-containing protein 2TMUB2 FP2653 UNQ1897/PRO4343Q71RG44
Transmembrane channel-like protein 4TMC4Q7Z4044
Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)TMED1 IL1RL1L IL1RL1LGQ134454
Transmembrane protein 120BTMEM120BA0PK004
Transmembrane protein 126ATMEM126AQ9H0614
Transmembrane protein 131-likeKIAA0922 TMEM131LA2VDJ04
Transmembrane protein 158 (40 kDa BINP-binding protein) (p40BBP) (Ras-induced senescence protein 1)TMEM158 HBBP RIS1Q8WZ714
Transmembrane protein 183ATMEM183A C1orf37Q8IXX54
Transmembrane protein 184ATMEM184AQ6ZMB54
Transmembrane protein 185A (Protein FAM11A)TMEM185A CXorf13 FAM11AQ8NFB24
Transmembrane protein 192TMEM192Q8IY954
Transmembrane protein 199TMEM199 C17orf32Q8N5114
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