EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1)HMGN5 NSBP1P829703
Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97)HRH3 GPCR97Q9Y5N13
Histatin-3 (Basic histidine-rich protein) (Hst) (Histidine-rich protein 3) (PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide (His3 20/44) (His3-(1-25)-peptide) (His3 1/25) (Histatin-3 1/25) (Histatin-6); His3-(20-43)-peptide (His3 20/43) (His3-(1-24)-peptide) (His3 1/24) (Histatin-3 1/24) (Histatin-5); His3-(20-32)-peptide (His3 20/32) (His3-(1-13)-peptide) (His3 1/13) (Histatin-3 1/13); His3-(20-31)-peptide (His3 20/31) (His3-(1-12)-peptide) (His3 1/12) (Histatin-3 1/12); His3-(20-30)-peptide (His3 20/30) (His3-(1-11)-peptide) (His3 1/11) (Histatin-3 1/11); His3-(24-32)-peptide (His3 24/32) (His3-(5-13)-peptide) (His3 5/13) (Histatin-3 5/13); His3-(24-31)-peptide (His3 24/31) (His3-(5-12)-peptide) (His3 5/12) (Histatin-11) (Histatin-3 5/12); His3-(24-30)-peptide (His3 24/30) (His3-(5-11)-peptide) (His3 5/11) (Histatin-12) (Histatin-3 5/11); His3-(25-32)-peptide (His3 25/32) (His3-(6-13)-peptide) (His3 6/13) (Histatin-3 6/13); His3-(25-30)-peptide (His3 25/30) (His3-(6-11)-peptide) (His3 6/11) (Histatin-3 6/11); His3-(26-32)-peptide (His3 26/32) (His3-(7-13)-peptide) (His3 7/13) (Histatin-3 7/13); His3-(26-31)-peptide (His3 26/31) (His3-(7-12)-peptide) (His3 7/12) (Histatin-3 7/12); His3-(26-30)-peptide (His3 26/30) (His3-(7-11)-peptide) (His3 7/11) (Histatin-3 7/11); His3-(31-51)-peptide (His3 31/51) (His3-(12-32)-peptide) (His3 12/32) (Histatin-3 12/32) (Histatin-4); His3-(31-44)-peptide (His3 31/44) (His3-(12-25)-peptide) (His3 12/25) (Histatin-3 12/25) (Histatin-9); His3-(31-43)-peptide (His3 31/43) (His3-(12-24)-peptide) (His3 12/24) (Histatin-3 12/24) (Histatin-7); His3-(32-44)-peptide (His3 32/44) (His3-(13-25)-peptide) (His3 13/25) (Histatin-10) (Histatin-3 13/25); His3-(32-43)-peptide (His3 32-43) (His3-(13-24)-peptide) (His3 13/24) (Histatin-3 13/24) (Histatin-8); His3-(33-44)-peptide (His3 33/44) (His3-(14-25)-peptide) (His3 14/25) (Histatin-3 14/25); His3-(33-43)-peptide (His3 33/43) (His3-(14-24)-peptide) (His3 14/24) (Histatin-3 14/24); His3-(34-44)-peptide (His3 34/44) (His3-(15-25)-peptide) (His3 15/25) (Histatin-3 15/25); His3-(34-43)-peptide (His3 34/43) (His3-(15-24)-peptide) (His3 15/24) (Histatin-3 15/24); His3-(45-51)-peptide (His3 45/51) (His3-(26-32)-peptide) (His3 26/32) (Histatin-3 26/32); His3-(47-51)-peptide (His3 47/51) (His3-(28-32)-peptide) (His3 28/32) (Histatin-3 28/32); His3-(48-51)-peptide (His3 48/51) (His3-(29-32)-peptide) (His3 29/32) (Histatin-3 29/32)]HTN3 HIS2P155163
Histidine triad nucleotide-binding protein 3 (HINT-3) (EC 3.-.-.-)HINT3Q9NQE93
Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)KAT6B KIAA0383 MORF MOZ2 MYST4Q8WYB53
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300)EP300 P300Q094723
Histone deacetylase 4 (HD4) (EC 3.5.1.98)HDAC4 KIAA0288P565243
Histone demethylase UTY (EC 1.14.11.-) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein)UTYO146073
Histone H2AHIST1H2AK HIST1H2AG HIST1H2AI HIST1H2AL HIST1H2AM hCG_1640463 hCG_1640467 hCG_1641458 hCG_1643754 hCG_1743060A4FTV93
Histone H2AHIST1H2AH hCG_1640359A3KPC73
Histone H2A type 1 (H2A.1) (Histone H2A/p)HIST1H2AG H2AFP; HIST1H2AI H2AFC; HIST1H2AK H2AFD; HIST1H2AL H2AFI; HIST1H2AM H2AFNP0C0S83
Histone H2A type 2-BHIST2H2ABQ8IUE63
Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.Bbd)H2AFB1P0C5Y93
Histone H2B type 1-L (Histone H2B.c) (H2B/c)HIST1H2BL H2BFCQ998803
Histone H3.1t (H3/t) (H3t) (H3/g)HIST3H3 H3FTQ166953
Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein)HINFP MIZF ZNF743Q9BQA53
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7Q9UMN63
Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.43) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)SETDB2 C13orf4 CLLD8 KMT1FQ96T683
Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion gene-containing protein) (HsMar1) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.43); Mariner transposase Hsmar1 (EC 3.1.-.-)]SETMARQ53H473
HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)HLA-DPB1 HLA-DP1BP044403
HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5)HLA-DRB5Q301543
HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG)HMGXB4 HMG2L1 HMGBCGQ9UGU53
HMOX1 protein (Heme oxygenase (Decycling) 1)HMOX1 hCG_40033Q6FH113
HNRPU protein0Q96BA73
Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9)HJURP FAKTS FLEG1 URLC9Q8NCD33
Homeobox protein aristaless-like 4ALX4 KIAA1788Q9H1613
Homeobox protein BarH-like 2BARX2Q9UMQ33
Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein cux-1)CUX1 CUTL1P398803
Homeobox protein DLX-1DLX1P561773
Homeobox protein Hox-A13 (Homeobox protein Hox-1J)HOXA13 HOX1JP312713
Homeobox protein Hox-A3 (Homeobox protein Hox-1E)HOXA3 HOX1EO433653
Homeobox protein Hox-B13HOXB13Q928263
Homeobox protein Hox-B3 (Homeobox protein Hox-2.7) (Homeobox protein Hox-2G)HOXB3 HOX2GP146513
Homeobox protein Hox-C13 (Homeobox protein Hox-3G)HOXC13 HOX3GP312763
Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)NKX3-1 NKX3.1 NKX3AQ998013
Homeobox protein OTX1 (Orthodenticle homolog 1)OTX1P322423
Homeobox protein OTX2 (Orthodenticle homolog 2 (Drosophila), isoform CRA_b)OTX2 hCG_32530F1T0D13
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)SIX1Q154753
Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1)HIPK3 DYRK6 FIST3 PKYQ9H4223
Homeodomain-interacting protein kinase 4 (EC 2.7.11.1)HIPK4Q8NE633
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)HERPUD1 HERP KIAA0025 MIF1Q150113
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 proteinHERPUD2Q9BSE43
HPCAL1 protein (Hippocalcin-like 1) (Hippocalcin-like 1, isoform CRA_a) (Putative uncharacterized protein HPCAL1) (cDNA FLJ78291, highly similar to Homo sapiens hippocalcin-like 1 (HPCAL1), transcript variant 2, mRNA)HPCAL1 hCG_23828Q6FGY13
Huntingtin (Huntington disease protein) (HD protein)HTT HD IT15P428583
Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)HIP1R HIP12 KIAA0655O751463
Hyaluronan synthase 1HAS1Q8IYH33
Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Cell growth-inhibiting gene 16 protein) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase)HAO2 HAOX2 GIG16Q9NYQ33
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)HMGCS2P548683
Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7)HIF3A BHLHE17 MOP7 PASD7Q9Y2N73
Hypoxia-inducible lipid droplet-associated protein (Hypoxia-inducible gene 2 protein)HILPDA C7orf68 HIG2Q9Y5L23
IgA-inducing protein homologIGIP C5orf53A6NJ693
IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)FCGBPQ9Y6R73
IL10 protein (Interleukin 10)IL10 hCG_22208Q6FGW43
IL6 protein (Interleukin 6 (Interferon, beta 2)) (Interleukin 6 (Interferon, beta 2), isoform CRA_a) (Putative uncharacterized protein IL6)IL6 hCG_38231 tcag7.131Q75MH23
Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule)IGDCC3 PUNCQ8IVU13
Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)IPO13 KIAA0724 RANBP13O948293
Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)IPO4 IMP4B RANBP4Q8TEX93
Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)PLCL2 KIAA1092 PLCE2Q9UPR03
Inactive polyglycylase TTLL10 (Tubulin--tyrosine ligase-like protein 10)TTLL10Q6ZVT03
InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions)INADL PATJQ8NI353
Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)INHBAP084763
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB)IKBKB IKKBO149203
Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein)IKBIP IKIPQ70UQ03
Inner nuclear membrane protein Man1 (LEM domain-containing protein 3)LEMD3 MAN1Q9Y2U83
INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4)INO80B HMGA1L4 PAPA1 ZNHIT4Q9C0863
INO80 complex subunit DINO80DQ53TQ33
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)PPA1 IOPPP PPQ151813
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1ITPRIPL1 KIAA1754LQ6GPH63
Insulin growth factor-like family member 1IGFL1 UNQ644/PRO1274Q6UW323
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]ITM2B BRI BRI2Q9Y2873
Integrator complex subunit 12 (Int12) (PHD finger protein 22)INTS12 PHF22 SBBI22Q96CB83
Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)ITGAX CD11CP207023
Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein)ITGBL1 OSCP TIEDO959653
Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16)ILKAPQ9H0C83
Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin)ITLN1 INTL ITLN LFR UNQ640/PRO1270Q8WWA03
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)ICAM1P053623
Intercellular adhesion molecule 2 (ICAM-2) (CD antigen CD102)ICAM2P135983
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)IFNAR1 IFNARP171813
Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (CD antigen CD119)IFNGR1P152603
Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C)IFNL3 IL28B IL28C ZCYTO22Q8IZI93
Interferon regulatory factor 1 (IRF-1)IRF1P109143
Interferon regulatory factor 2 (IRF-2)IRF2P143163
Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]MX1P205913
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56)IFIT1 G10P1 IFI56 IFNAI1 ISG56P099143
Interferon-induced transmembrane protein 5 (Bone-restricted interferon-induced transmembrane protein-like protein) (BRIL) (Dispanin subfamily A member 1) (DSPA1)IFITM5A6NNB33
Interleukin 28A (Interleukin 28A (Interferon, lambda 2))IL28AQ45KQ83
Interleukin enhancer binding factor 2 variant (Fragment)0Q53FG33
Interleukin-1 receptor-like 2 (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2)IL1RL2 IL1RRP2Q9HB293
Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)IL10RA IL10RQ136513
Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)IL13RA1 IL13R IL13RAP785523
Interleukin-17C (IL-17C) (Cytokine CX2)IL17C UNQ561/PRO1122Q9P0M43
Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360)IL21R NILR UNQ3121/PRO10273Q9HBE53
Interleukin-22 receptor subunit alpha-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (Cytokine receptor class-II member 10) (Cytokine receptor family 2 member 10) (CRF2-10) (Cytokine receptor family type 2, soluble 1) (CRF2-S1) (Interleukin-22-binding protein) (IL-22BP) (IL22BP) (ZcytoR16)IL22RA2 UNQ5793/PRO19598/PRO19822Q969J53
Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19)IL23A SGRF UNQ2498/PRO5798Q9NPF73
Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)IL27RA CRL1 TCCR WSX1 UNQ296/PRO336Q6UWB13
Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)EBI3 IL27BQ142133
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)ITSN2 KIAA1256 SH3D1B SWAPQ9NZM33
Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)ALPIP099233
Intraflagellar transport protein 52 homolog (Protein NGD5 homolog)IFT52 C20orf9 NGD5 CGI-53Q9Y3663
Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2)IFT74 CCDC2 CMG1Q96LB33
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