EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
LYPLA1 protein (Lysophospholipase I, isoform CRA_a) (cDNA FLJ78542, highly similar to Homo sapiens lysophospholipase I (LYPLA1), mRNA) (cDNA, FLJ94339, Homo sapiens lysophospholipase I (LYPLA1), mRNA)LYPLA1 hCG_1983522Q6IAQ13
Lysine-rich coiled-coil protein 1 (Cryptogenic hepatitis-binding protein 2)KRCC1 CHBP2 BM-003 BM-044Q9NPI73
Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)KDM2A CXXC8 FBL7 FBXL11 JHDM1A KIAA1004Q9Y2K73
Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)PHF2 KIAA0662O751513
Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)ACP6 ACPL1 LPAP UNQ205/PRO231Q9NPH03
Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)LPAR1 EDG2 LPA1Q926333
Lysoplasmalogenase-like protein TMEM86A (Transmembrane protein 86A)TMEM86AQ8N2M43
Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Lipase A) (Sterol esterase)LIPAP385713
Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]GAAP102533
Lysosomal amino acid transporter 1 homolog (PQ-loop repeat-containing protein 2)PQLC2Q6ZP293
Lysyl oxidaseLOX hCG_37363D0PNI23
Lysyl oxidase homolog 4 (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C)LOXL4 LOXCQ96JB63
M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)CDC25CP303073
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)CSF1R FMSP073333
Macrophage receptor with collagenous structure (Putative uncharacterized protein MARCO) (cDNA, FLJ93629, Homo sapiens macrophage receptor with collagenous structure(MARCO), mRNA)MARCO hCG_16205Q4ZG403
MAD, mothers against decapentaplegic homolog 2 (Drosophila) (SMAD, mothers against DPP homolog 2 (Drosophila), isoform CRA_b) (cDNA, FLJ93422, Homo sapiens MAD, mothers against decapentaplegic homolog 2(Drosophila) (MADH2), mRNA)SMAD2 hCG_22544Q53XR63
Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48)MDP1Q86V883
Major facilitator superfamily domain-containing protein 9MFSD9 PSEC0066Q8NBP53
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase)ADPRM C17orf48 MDS006 Nbla03831Q3LIE53
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]MASP2O001873
Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta)GMPPBQ9Y5P63
MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)MAPKAPK5 PRAKQ8IW413
MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21)MAP6D1Q9H9H53
MAP7 domain-containing protein 2MAP7D2Q96T173
MARVEL domain-containing protein 2 (Tricellulin)MARVELD2 TRICQ8N4S93
MARVEL domain-containing protein 3MARVELD3 MRVLDC3Q96A593
Mas-related G-protein coupled receptor member F (Mas-related gene F protein) (G-protein coupled receptor 140) (G-protein coupled receptor 168)MRGPRF GPR140 GPR168 MRGF PSEC0142Q96AM13
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)MELK KIAA0175Q146803
Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein)MGP MGLAP GIG36P084933
Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2)MMP15P515113
Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)MMP16 MMPX2P515123
Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP)MMP25 MMP20 MMPL1 MT6MMPQ9NPA23
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]MMP9 CLG4BP147803
Matrix-remodeling-associated protein 8 (Limitrin)MXRA8Q9BRK33
Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4)MXD4 BHLHC12 MAD4Q145823
MDS1 and EVI1 complex locus protein EVI1 (Ecotropic virus integration site 1 protein homolog) (EVI-1)MECOM EVI1Q031123
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2Q156483
Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1)MED31 SOH1 CGI-125Q9Y3C73
MEF2-activating motif and SAP domain-containing transcriptional regulator (MEF2-activating SAP transcriptional regulatory protein)MAMSTR MASTRQ6ZN013
Meiosis-specific nuclear structural protein 1MNS1Q8NEH63
Meiotic nuclear division protein 1 homologMND1 GAJQ9BWT63
Melanocortin 1 receptor (Melanocortin 1 receptor (Alpha melanocyte stimulating hormone receptor)) (cDNA FLJ14170 fis, clone NT2RP2002105, highly similar to Melanocyte-stimulating hormone receptor)MC1R hCG_2039647Q1JUL43
Melanocortin-2 receptor accessory protein (B27) (Fat cell-specific low molecular weight protein) (Fat tissue-specific low MW protein)MRAP C21orf61 FALPQ8TCY53
Melanocyte protein PMEL (ME20-M) (ME20M) (Melanocyte protein Pmel 17) (Melanocytes lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (P1) (P100) (Premelanosome protein) (Silver locus protein homolog) [Cleaved into: M-alpha (95 kDa melanocyte-specific secreted glycoprotein) (P26) (Secreted melanoma-associated ME20 antigen) (ME20-S) (ME20S); M-beta]PMEL D12S53E PMEL17 SILVP409673
Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)PRAME MAPE OIP4P783953
Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen)MAGEA11 MAGE11P433643
Melanoma-associated antigen 12 (Cancer/testis antigen 1.12) (CT1.12) (MAGE-12 antigen) (MAGE12F antigen)MAGEA12 MAGE12P433653
Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)MFI2 MAP97P085823
Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)CD46 MCP MIC10P155293
Membrane protein MLC1MLC1 KIAA0027 WKL1Q150493
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)PKMYT1 MYT1Q996403
Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1)MTF1Q148723
Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)CNNM3 ACDP3Q8NE013
MetallothioneinMTP MT1B MT1QQ86YX03
Metallothionein 1H-like protein 1MT1HL1P0DM353
Metastasis-associated protein MTA1MTA1Q133303
Metaxin-3MTX3Q5HYI73
Meteorin-like proteinMETRNLQ641Q33
Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)MBD1 CXXC3 PCM1Q9UIS93
Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)MBD3O959833
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1)ALDH6A1 MMSDHQ022523
Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)MUTP220333
Methyltransferase-like protein 20 (EC 2.1.1.-)METTL20 C12orf72Q8IXQ93
Methyltransferase-like protein 7A (EC 2.1.1.-) (Protein AAM-B)METTL7A PRO0066 UNQ1902/PRO4348Q9H8H33
Microtubule-associated protein 1 light chain 3 beta, isoform CRA_c (Putative uncharacterized protein DKFZp762B153) (cDNA FLJ77661, highly similar to Homo sapiens microtubule-associated protein 1 light chain 3 beta(MAP1LC3B), mRNA)DKFZp762B153 MAP1LC3B hCG_32374Q658J63
Minor histocompatibility protein HB-1 [Cleaved into: Minor histocompatibility antigen HB-1 (mHag HB-1)]HMHB1O979803
Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)MIS18BP1 C14orf106 KIAA1903 KNL2 M18BP1Q6P0N03
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)MINK1 B55 MAP4K6 MINK YSK2 ZC3Q8N4C83
Mitochondria-eating protein (Spermatogenesis-associated protein 18)SPATA18 MIEAPQ8TC713
Mitochondrial calcium uniporter regulatory subunit MCUb (MCUb) (Coiled-coil domain-containing protein 109B)CCDC109B MCUBQ9NWR83
Mitochondrial cardiolipin hydrolase (EC 3.1.-.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD 6) (Protein zucchini homolog)PLD6Q8N2A83
Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)MTCH2 MIMP HSPC032Q9Y6C93
Mitochondrial dynamic protein MID49 (Mitochondrial dynamic protein of 49 kDa) (Mitochondrial elongation factor 2) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein)MIEF2 MID49 SMCR7Q96C033
Mitochondrial import inner membrane translocase subunit TIM50TIMM50 TIM50 PRO1512Q3ZCQ83
Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog)TOMM22 TOM22Q9NS693
Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like)TOMM40L TOMM40BQ969M13
Mitochondrial NADH dehydrogenase ubiquinone flavoprotein 10E5KNH53
Mitochondrial thiamine pyrophosphate carrier (Mitochondrial uncoupling protein 1) (Solute carrier family 25 member 19)SLC25A19 DNC MUP1Q9HC213
Mitochondrial transcription factor A (Transcription factor A, mitochondrial, isoform CRA_c)TFAM hCG_40210E5KSU53
Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 6.3.2.-) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (MAPL) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218)MUL1 C1orf166 GIDE MAPL MULAN RNF218Q969V53
Mitochondrial uncoupling protein 3 (UCP 3) (Solute carrier family 25 member 9)UCP3 SLC25A9P559163
Mitogen-activated protein kinase 3MAPK3L7RXH53
Mitogen-activated protein kinase kinase 1 (Mitogen-activated protein kinase kinase 1, isoform CRA_a) (cDNA FLJ76051, highly similar to Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA)MAP2K1 hCG_24510A4QPA93
Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)MAP3K10 MLK2 MSTQ027793
Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)MAP3K13 LZKO432833
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)MAP3K6 ASK2 MAPKKK6 MEKK6O953823
Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)MAP4K2 GCK RAB8IPQ128513
Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)MAD1L1 MAD1 TXBP181Q9Y6D93
Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)MZT1 C13orf37 MOZART1Q08AG73
MKL/myocardin-like protein 2 (Megakaryoblastic leukemia 2) (Myocardin-related transcription factor B) (MRTF-B)MKL2 KIAA1243 MRTFBQ9ULH73
MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B)MOB3B MOBKL2BQ86TA13
Molybdopterin synthase sulfur carrier subunit (MOCO1-A) (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Molybdopterin-synthase small subunit) (Sulfur carrier protein MOCS2A)MOCS2 MOCO1O960333
Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)SLC16A12 MCT12Q6ZSM33
Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)SLC16A7 MCT2O606693
Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6)SLC16A6 MCT6 MCT7O154033
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]CD14P085713
MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled-coil domain protein 1)MORC2 KIAA0852 ZCWCC1Q9Y6X93
Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) (hSMAD6)SMAD6 MADH6O435413
Motile sperm domain-containing protein 2MOSPD2Q8NHP63
Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)MNX1 HLXB9P502193
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