EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Nucleoporin-like protein 2 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1)NUPL2 CG1O155043
Nucleoside diphosphate kinase 7 (NDK 7) (NDP kinase 7) (EC 2.7.4.6) (nm23-H7)NME7Q9Y5B83
NudC domain-containing protein 2NUDCD2Q8WVJ23
Numb-like protein (Numb-related protein) (Numb-R)NUMBLQ9Y6R03
Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD)OLFM4 GW112 UNQ362/PRO698Q6UX063
Olfactory receptor 10G9 (Olfactory receptor 10G10)OR10G9 OR10G10PQ8NGN43
Olfactory receptor 10H5 (Olfactory receptor OR19-25) (Olfactory receptor OR19-26)OR10H5Q8NGA63
Olfactory receptor 1M1 (Olfactory receptor 19-6) (OR19-6) (Olfactory receptor OR19-5)OR1M1Q8NGA13
Olfactory receptor 2L8 (Olfactory receptor OR1-46)OR2L8Q8NGY93
Olfactory receptor 2T3OR2T3Q8NH033
Olfactory receptor 2T33 (Olfactory receptor OR1-56)OR2T33Q8NG763
Olfactory receptor 4D10 (Olfactory receptor OR11-251)OR4D10 OR4D10PQ8NGI63
Olfactory receptor 4N4 (Olfactory receptor OR15-1) (Olfactory receptor OR15-5)OR4N4Q8N0Y33
Olfactory receptor 52W1 (Olfactory receptor OR11-71)OR52W1 OR52W1PQ6IF633
Oligoribonuclease, mitochondrial (EC 3.1.-.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)REXO2 SFN SMFN CGI-114Q9Y3B83
Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) (IgLON family member 1)OPCML IGLON1 OBCAMQ149823
Optic atrophy 3 proteinOPA3Q9H6K43
Orexin (Hypocretin) (Hcrt) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)]HCRT OX PPORX PPOXO436123
ORM1-like protein 1 (Adoplin-1)ORMDL1 HSPC202Q9P0S33
OtoancorinOTOAQ7RTW83
Outer dense fiber protein 2-likeODF2L KIAA1229Q9ULJ13
Oxidase (Cytochrome c) assembly 1-likeOXA1LQ2M1J63
Oxidation resistance protein 1OXR1 Nbla00307Q8N5733
Oxidative stress-induced growth inhibitor 2 (hT41)OSGIN2 C8orf1Q9Y2363
Oxidative stress-responsive serine-rich protein 1 (Oxidative stress-responsive protein 1) (Peroxide-inducible transcript 1 protein)OSER1 BM-038 C20orf111 HSPC168 HSPC207Q9NX313
Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)OSBPL3 KIAA0704 ORP3 OSBP3Q9H4L53
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)NR1H3 LXRAQ131333
P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor)P2RX2 P2X2Q9UBL93
P2Y purinoceptor 11 (P2Y11)P2RY11Q96G913
P2Y purinoceptor 13 (P2Y13) (G-protein coupled receptor 86) (G-protein coupled receptor 94)P2RY13 GPR86 GPR94 FKSG77Q9BPV83
P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor)P2RY2 P2RU1P412313
P2Y purinoceptor 6 (P2Y6)P2RY6 PP2891Q150773
PACRG-like proteinPACRGL C4orf28Q8N7B63
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)SIN3B KIAA0700O751823
Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)PRRX1 PMX1P548213
Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22)ZDHHC22 C14orf59Q8N9663
Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376)ZDHHC6 ZNF376Q9H6R63
Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)PDX1 IPF1 STF1P529453
Pannexin-1PANX1 MRS1 UNQ2529/PRO6028Q96RD73
PAP-associated domain-containing protein 5 (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)PAPD5Q8NDF83
Papillary renal cell carcinoma (Translocation-associated)PRCCQ96FT43
Paralemmin-3PALM3A6NDB93
Paraneoplastic antigen MA2PNMA2Q5U5Z33
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)PTH1R PTHR PTHR1Q034313
Parvalbumin alphaPVALBP204723
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)PAXIP1 PAXIP1L PTIP CAGF28Q6ZW493
PCTP-like protein (PCTP-L) (Antigen NY-CO-28) (START domain-containing protein 10) (StARD10) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10)STARD10 SDCCAG28 CGI-52Q9Y3653
PDZ domain-containing protein GIPC2GIPC2Q8TF653
PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96)PDZK1IP1 MAP17Q131133
Pecanex-like protein 2PCNXL2 KIAA0435A6NKB53
Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)PEF1 ABP32 UNQ1845/PRO3573Q9UBV83
Pentraxin-4PTX4 C16orf38Q96A993
Peptidyl-prolyl cis-trans isomerase A-like 4G (PPIase A-like 4G) (EC 5.2.1.8) (Peptidylprolyl cis-trans isomerase A-like 4)PPIAL4GA2BFH13
Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP)PPIH CYP20 CYPHO434473
Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1)PTRH2 BIT1 PTH2 CGI-147Q9Y3E53
Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein)ICT1 DS1Q141973
PeriaxinPRX KIAA1620Q9BXM03
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)PPL KIAA0568O604373
Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)PEX14O753813
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase)PAOX PAO UNQ1923/PRO4398Q6QHF93
Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7)PEX7 PTS2RO006283
Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1)PEX1O439333
Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)PEX10 RNF69O606833
Peroxisome biogenesis factor 2 (35 kDa peroxisomal membrane protein) (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) (RING finger protein 72)PEX2 PAF1 PMP3 PMP35 PXMP3 RNF72P283283
Pescadillo homologPES1O005413
Pescadillo homolog 1 (Pescadillo homolog 1, containing BRCT domain (Zebrafish), isoform CRA_a) (cDNA, FLJ96584, Homo sapiens pescadillo homolog 1, containing BRCT domain(zebrafish) (PES1), mRNA)PES1 hCG_2010949B2RDF23
PFAS protein (Fragment)PFASQ6P4B43
PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein)PSD4 EFA6B TICQ8NDX13
PHD finger protein 12 (PHD factor 1) (Pf1)PHF12 KIAA1523Q96QT63
PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1)PHF13Q86YI83
PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)PHF5AQ7RTV03
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)PMAIP1 NOXAQ137943
Phosphatase and actin regulator 4PHACTR4 PRO2963Q8IZ213
Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)CDS2O956743
Phosphatidylethanolamine-binding protein 10D9IAI13
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase J)INPP5J PIB5PA PIPPQ157353
Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha)PI4K2AQ9BTU63
Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)PI4K2BQ8TCG23
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C)PIGC GPI2Q925353
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q)PIGQ GPI1Q9BRB33
Phosphatidylinositol-glycan biosynthesis class W protein (PIG-W) (EC 2.3.-.-)PIGWQ7Z7B13
Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8)PMM2O153053
Phosphoribosyl pyrophosphate amidotransferase proprotein variant (Fragment)0Q59G633
Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor)NR2E3 PNR RNRQ9Y5X43
Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)PIRO006253
Placenta copper monamine oxidase (Fragment)0Q9UEU73
Plakophilin-2PKP2Q999593
Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)ATP2B3Q167203
Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]PLGP007473
Platelet glycoprotein Ib beta chain (GP-Ib beta) (GPIb-beta) (GPIbB) (Antigen CD42b-beta) (CD antigen CD42c)GP1BBP132243
Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC 3.1.1.47) (Serine-dependent phospholipase A2) (SD-PLA2) (hSD-PLA2)PAFAH2Q994873
Pleckstrin (Platelet 47 kDa protein) (p47)PLEK P47P085673
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)PLEKHA5 KIAA1686 PEPP2Q9HAU03
Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)PLEKHA6 KIAA0969 PEPP3Q9Y2H53
Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15)PLEKHF1 APPD LAPF ZFYVE15Q96S993
Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)PLEKHG3 KIAA0599A1L3903
Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)PLEKHG5 KIAA0720O948273
Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x)PLEKHJ1 GNRPXQ9NW613
Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)PLEKHM2 KIAA0842 SKIPQ8IWE53
Pleckstrin homology-like domain family B member 3PHLDB3Q6NSJ23
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