EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)CDKN2A CDKN2 MTS1P427712
Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE)CDKL3 NKIAMREQ8IVW42
Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)CDKL5 STK9O760392
Cyclin-F (F-box only protein 1)CCNF FBX1 FBXO1P410022
Cyclin-L2 (Paneth cell-enhanced expression protein)CCNL2 SB138Q96S942
CYR61 protein (Cysteine-rich, angiogenic inducer, 61, isoform CRA_a) (cDNA, FLJ95400, highly similar to Homo sapiens cysteine-rich, angiogenic inducer, 61 (CYR61), mRNA)CYR61 hCG_23652Q6FI182
Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]CSTA STF1 STFAP010402
Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)CST1P010372
Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagin-2) (Autophagy-related cysteine endopeptidase 2) (Autophagy-related protein 4 homolog A) (hAPG4A)ATG4A APG4A AUTL2Q8WYN02
Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagin-3) (Autophagy-related cysteine endopeptidase 3) (Autophagy-related protein 4 homolog C)ATG4C APG4C AUTL1 AUTL3Q96DT62
Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)CSAD CSDQ9Y6002
Cysteine-rich and transmembrane domain-containing protein 1CYSTM1 C5orf32 ORF1-FL49Q9H1C72
Cysteine-rich secretory protein 1 (CRISP-1) (AEG-like protein) (ARP) (Acidic epididymal glycoprotein homolog)CRISP1 AEGL1P541072
Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2)CRISPLD2 CRISP11 LCRISP2 UNQ2914/PRO1156/PRO9783Q9H0B82
Cytochrome b reductase 1 (EC 1.-.-.-) (Duodenal cytochrome b) (Ferric-chelate reductase 3)CYBRD1 DCYTB FRRS3Q53TN42
Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R)CYB5R4 NCB5ORQ7L1T62
Cytochrome c oxidase assembly protein COX11, mitochondrial (cDNA FLJ56729, highly similar to Cytochrome c oxidase assembly protein COX11, mitochondrial)COX11B4DI262
Cytochrome c oxidase protein 20 homologCOX20 FAM36AQ5RI152
Cytochrome c oxidase subunit 6B2 (Cancer/testis antigen 59) (CT59) (Cytochrome c oxidase subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)COX6B2Q6YFQ22
Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)COX7A1 COX7AHP243102
Cytochrome P450 20A1 (EC 1.14.-.-)CYP20A1 UNQ667/PRO1301Q6UW022
Cytochrome P450 2C19 (EC 1.14.13.-) ((R)-limonene 6-monooxygenase) (EC 1.14.13.80) ((S)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 7-monooxygenase) (EC 1.14.13.49) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Mephenytoin 4-hydroxylase)CYP2C19P332612
Cytochrome P450 3A43 (EC 1.14.14.1)CYP3A43Q9HB552
Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450 HLp2) (Cytochrome P450-PCN3)CYP3A5P208152
Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)CYP4F12 UNQ568/PRO1129Q9HCS22
Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1)CYP4X1 UNQ1929/PRO4404Q8N1182
Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)CYTH3 ARNO3 GRP1 PSCD3O437392
Cytohesin-4 (PH, SEC7 and coiled-coil domain-containing protein 4)CYTH4 CYT4 PSCD4Q9UIA02
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)CISH G18Q9NSE22
Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)DYNC1I1 DNCI1 DNCIC1O145762
Cytosine-specific methyltransferase (EC 2.1.1.37)DNMT1I6L9H22
Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Phospholipase A2 group IVB)PLA2G4BP0C8692
Cytosolic phospholipase A2 zeta (cPLA2-zeta) (EC 3.1.1.4) (Phospholipase A2 group IVF)PLA2G4FQ68DD22
Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)SPECC1 CYTSB NSP5Q5M7752
Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)CTLA4 CD152P164102
CYTSA protein (KIAA0376 protein, isoform CRA_a)CYTSA KIAA0376 hCG_1811992B2RMV22
D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1)DDOQ994892
Dachshund homolog 1 (Dach1)DACH1 DACHQ9UI362
DALR anticodon-binding domain-containing protein 3DALRD3Q5D0E62
Dapper homolog 2 (Dapper antagonist of catenin 2)DACT2 C6orf116 PP13671Q5SW242
DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X)MOXD1 MOX UNQ2493/PRO5780Q6UVY62
DC-STAMP domain-containing protein 1DCST1Q5T1972
DDB1- and CUL4-associated factor 12-like protein 2 (WD repeat-containing protein 40C)DCAF12L2 WDR40CQ5VW002
DDB1- and CUL4-associated factor 15DCAF15 C19orf72Q66K642
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)DAPK1 DAPKP533552
Death-associated protein-like 1 (Early epithelial differentiation-associated protein)DAPL1 EEDAA0PJW82
Decaprenyl-diphosphate synthase subunit 1 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 1) (Decaprenyl pyrophosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1)PDSS1 DPS1 TPRTQ5T2R22
Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)DOCK11 ZIZ2Q5JSL32
Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)DOCK3 KIAA0299 MOCAQ8IZD92
Dedicator of cytokinesis protein 4DOCK4 KIAA0716Q8N1I02
Dedicator of cytokinesis protein 5DOCK5Q9H7D02
Dedicator of cytokinesis protein 6DOCK6 KIAA1395Q96HP02
Dedicator of cytokinesis protein 8DOCK8Q8NF502
Defensin, alpha 3, neutrophil-specificDEFA3Q6EZE92
Defensin, alpha 6, Paneth cell-specific (Defensin, alpha 6, preproprotein)DEFA6 hCG_22280Q6EZF92
Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4)DHRS7 DHRS7A RETSDR4 CGI-86 UNQ285/PRO3448Q9Y3942
Deleted in azoospermia protein 2DAZ2Q131172
Delta-type opioid receptor (D-OR-1) (DOR-1)OPRD1 OPRDP411432
Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9)DMTN DMT EPB49Q084952
DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B)DENND1B C1orf218 FAM31BQ6P3S12
DENN domain-containing protein 2CDENND2CQ68D512
DENN domain-containing protein 3DENND3 KIAA0870A2RUS22
Deoxycytidine kinase (dCK) (EC 2.7.1.74)DCKP277072
Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa)DNASE1 DNL1 DRNIP248552
Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)DNASE2 DNASE2A DNL2O001152
DEP domain-containing protein 1ADEPDC1 DEPDC1AQ5TB302
DEP domain-containing protein 7 (Protein TR2/D15)DEPDC7Q96QD52
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)DSC3 CDHF3 DSC4Q145742
Desmoglein-2 (Cadherin family member 5) (HDGC)DSG2 CDHF5Q141262
Developmental pluripotency-associated protein 2 (Pluripotent embryonic stem cell-related gene 1 protein)DPPA2 PESCRG1Q7Z7J52
Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1)RASD1 AGS1 DEXRAS1Q9Y2722
Di-N-acetylchitobiase (EC 3.2.1.-)CTBS CTBQ014592
Dickkopf-like protein 1 (Cancer/testis antigen 34) (CT34) (Protein soggy-1) (SGY-1)DKKL1 SGY1 UNQ735/PRO1429Q9UK852
Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)DKK2 UNQ682/PRO1316Q9UBU22
Diencephalon/mesencephalon homeobox protein 1 (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1)DMBX1 MBX OTX3 PAXBQ8NFW52
Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein)DEF6 IBPQ9H4E72
Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase)DPYSQ141172
Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (h-mtTFB) (h-mtTFB1) (hTFB1M) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)TFB1M CGI-75Q8WVM02
Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4)FMO4 FMO2P315122
Dipeptidyl aminopeptidase-like protein 6 (DPPX) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI)DPP6P426582
Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]DPP4 ADCP2 CD26P274872
Disabled homolog 1DAB1O755532
Disheveled-associated activator of morphogenesis 2DAAM2 KIAA0381Q86T652
Disintegrin and metalloproteinase domain-containing protein 30 (ADAM 30) (EC 3.4.24.-)ADAM30 UNQ2509/PRO5997Q9UKF22
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a)ADAM8 MS2P783252
Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1)DIXDC1 CCD1 KIAA1735Q155Q32
DmX-like protein 1 (X-like 1 protein)DMXL1 XL1Q9Y4852
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)DNMT3AQ9Y6K12
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)DNMT3BQ9UBC32
DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)DDIT4L REDD2 RTP801LQ96D032
DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator)DRAM1 DRAMQ8N6822
DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)ERCC6L PICHQ2NKX82
DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)LIG4P499172
DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)REV3L POLZ REV3O606732
DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)ERCC4 ERCC11 XPFQ928892
DNA repair protein RAD52 homologRAD52P433512
DNA repair protein SWI5 homolog (HBV DNAPTP1-transactivated protein A) (Protein SAE3 homolog)SWI5 C9orf119 SAE3Q1ZZU32
DNA replication complex GINS protein PSF3 (GINS complex subunit 3)GINS3 PSF3Q9BRX52
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)TOPBP1 KIAA0259Q925472
DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta-1)TOP3B TOP3B1O959852
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