EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Protein MUM) (Tissue carboxypeptidase inhibitor) (TCI)LXNQ9BS402
Lathosterol oxidase (EC 1.14.21.6) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase)SC5D SC5DLO758452
Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26)MIP AQP0P303012
Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1)L3MBTL1 KIAA0681 L3MBT L3MBTLQ9Y4682
Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A)LURAP1 C1orf190 LRAP35A LRP35AQ96LR22
Leucine rich repeat neuronal 3 (Leucine rich repeat neuronal 3, isoform CRA_a)LRRN3 hCG_1643830 tcag7.22A4D0T12
Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1)LZTS3 KIAA0552 PROSAPIP1O602992
Leucine-rich repeat and fibronectin type-III domain-containing protein 4LRFN4 SALM3Q6PJG92
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)LINGO1 LERN1 LRRN6A UNQ201/PRO227Q96FE52
Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA)LRWD1 CENP33 ORCAQ9UFC02
Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5)LRRN2 GAC1 LRRN5 UNQ256/PRO293O753252
Leucine-rich repeat neuronal protein 4 (Neuronal leucine-rich repeat protein 4) (NLRR-4)LRRN4 C20orf75Q8WUT42
Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)LRR1 PPIL5Q96L502
Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)SHOC2 KIAA0862Q9UQ132
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)LRRK1 KIAA1790Q38SD22
Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1)FLRT1 UNQ752/PRO1483Q9NZU12
Leucine-rich repeat-containing protein 14BLRRC14BA6NHZ52
Leucine-rich repeat-containing protein 16BLRRC16B C14orf121Q8ND232
Leucine-rich repeat-containing protein 25 (Monocyte and plasmacytoid-activated protein)LRRC25 MAPA UNQ6169/PRO20174Q8N3862
Leucine-rich repeat-containing protein 32 (Garpin) (Glycoprotein A repetitions predominant) (GARP)LRRC32 D11S833E GARPQ143922
Leucine-rich repeat-containing protein 37A2LRRC37A2A6NM112
Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2)LRRC4 BAG NAG14 UNQ554/PRO1111Q9HBW12
Leucine-rich repeat-containing protein 47LRRC47 KIAA1185Q8N1G42
Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4)LRRC49Q8IUZ02
Leucine-rich repeat-containing protein 57LRRC57Q8N9N72
Leucine-rich repeat-containing protein 58LRRC58Q96CX62
Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)LRIG3 LIG3 UNQ287/PRO326/PRO335Q6UXM12
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)CD37 TSPAN26P110492
Leukocyte cell-derived chemotaxin 1 [Cleaved into: Chondrosurfactant protein (CH-SP); Chondromodulin-1 (Chondromodulin-I) (ChM-I)]LECT1 CHMIO758292
Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g)LILRA4 ILT7P599012
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)LILRB2 ILT4 LIR2 MIR10Q8N4232
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)LTK TYK1P293762
Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (LTB4 receptor JULF2) (Leukotriene B4 receptor BLT2) (Seven transmembrane receptor BLTR2)LTB4R2 BLT2R BLTR2Q9NPC12
Leukotriene-B(4) omega-hydroxylase 1 (EC 1.14.13.30) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1)CYP4F2P783292
Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1)LNX2 PDZRN1Q8N4482
LIM domain-containing protein ajubaAJUBA JUBQ96IF12
LIM homeobox transcription factor 1-alpha (LIM/homeobox protein 1.1) (LMX-1.1) (LIM/homeobox protein LMX1A)LMX1AQ8TE122
Limb region 1 protein homolog (Differentiation-related gene 14 protein)LMBR1 C7orf2 DIF14Q8WVP72
Lipid phosphate phosphatase-related protein type 2 (EC 3.1.3.4) (Plasticity-related gene 4 protein) (PRG-4)LPPR2 PRG4Q96GM12
Lipid phosphate phosphatase-related protein type 3 (EC 3.1.3.4) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2)LPPR3 PHP2 PRG2Q6T4P52
Lipocalin-like 1 proteinLCNL1Q6ZST42
Lipoma HMGIC fusion partner-like 4 proteinLHFPL4Q7Z7J72
Liver-expressed antimicrobial peptide 2 (LEAP-2)LEAP2Q969E12
Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2)SLC7A2 ATRC2 CAT2P525692
Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)FCGR2A CD32 FCG2 FCGR2A1 IGFR2P123182
Low-density lipoprotein receptor-related protein 5 (LRP-5)LRP5 LR3 LRP7O751972
LRRC8D proteinLRRC8DQ96GG52
Lung adenoma susceptibility protein 2LAS2 C18orf54Q8IYD92
LY6/PLAUR domain containing 4, isoform CRA_b (Sperm membrane receptor) (cDNA FLJ77180, highly similar to Homo sapiens LY6/PLAUR domain containing 4 (LYPD4), mRNA)SMR LYPD4 hCG_22329A8K8E02
Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)LY96 ESOP1 MD2Q9Y6Y92
LYR motif-containing protein 9LYRM9 C17orf108 HSD24A8MSI82
Lysine-specific demethylase 5C (EC 1.14.11.-) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169)KDM5C DXS1272E JARID1C SMCX XE169P412292
Lysine-specific demethylase 6A (EC 1.14.11.-) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein)KDM6A UTXO155502
Lysine-specific demethylase 6B (EC 1.14.11.-) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B)KDM6B JMJD3 KIAA0346O150542
LysM and putative peptidoglycan-binding domain-containing protein 2LYSMD2Q8IV502
LysM and putative peptidoglycan-binding domain-containing protein 4LYSMD4Q5XG992
Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1.-) (1-acylglycerophosphate O-acyltransferase) (EC 2.3.1.51) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (Lysophosphatidic acid acyltransferase) (LPAAT) (Lyso-PA acyltransferase) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 2) (O-acyltransferase domain-containing protein 2)MBOAT2 OACT2Q6ZWT72
Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5)LPCAT3 MBOAT5 OACT5Q6P1A22
Lysosomal acid phosphatase (LAP) (EC 3.1.3.2)ACP2P111172
Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide]MAN2B1 LAMAN MANBO007542
Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14)PPT2Q9UMR52
M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)CDC25AP303042
M96A-20Q7Z5342
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)MMP12 HMEP399002
Maestro heat-like repeat-containing protein family member 2B (HEAT repeat-containing protein 7B2)MROH2B HEATR7B2Q7Z7452
MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1)MPP6 VAM1Q9NZW52
Major facilitator superfamily domain-containing protein 5MFSD5 UNQ832/PRO1759Q6N0752
Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog)MFSD6 MMR2Q6ZSS72
Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)MR1Q954602
Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)PRNP ALTPRP PRIP PRPP041562
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)MCAT MTQ8IVS22
Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein)EPDR1 MERP1 UCC1Q9UM222
Mannan-binding lectin (Mannose-binding lectin (Protein C) 2, soluble (Opsonic defect)) (Mannose-binding lectin (Protein C) 2, soluble (Opsonic defect), isoform CRA_a) (Mannose-binding protein C)MBL2 hCG_27269Q5SQS32
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]MASP1 CRARF CRARF1 PRSS5P487402
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC)MAN1C1 MAN1A3 MAN1CQ9NR342
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)MARK4 KIAA1860 MARKL1Q96L342
MAP3K7 C-terminal-like protein (TAK1-like protein)MAP3K7CL C21orf7 TAK1LP570772
MARVEL domain-containing protein 1MARVELD1 MRVLDC1Q9BSK02
Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7)MRGPRD MRGDQ8TDS72
Mas-related G-protein coupled receptor member X1 (Sensory neuron-specific G-protein coupled receptor 3/4)MRGPRX1 MRGX1 SNSR3 SNSR4Q96LB22
Mas-related G-protein coupled receptor member X4 (Sensory neuron-specific G-protein coupled receptor 5/6)MRGPRX4 MRGX4 SNSR5 SNSR6Q96LA92
Mas-related G-protein coupled receptor MRG (MAS-R) (MAS1-like)MAS1L MRGP354102
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)KIT SCFRP107212
Mastermind-like domain-containing protein 1 (F18) (Protein CG1)MAMLD1 CG1 CXorf6Q134952
Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)MMP17 MT4MMPQ9ULZ92
Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18)MMP19 MMP18 RASIQ995422
Matrix metalloproteinase-23 (MMP-23) (EC 3.4.24.-) (Femalysin) (MIFR-1) (Matrix metalloproteinase-21) (MMP-21) (Matrix metalloproteinase-22) (MMP-22) [Cleaved into: Matrix metalloproteinase-23, soluble form]MMP23A MMP21; MMP23B MMP21 MMP22O759002
Matrix metalloproteinase-27 (MMP-27) (EC 3.4.24.-)MMP27 UNQ2503/PRO5992Q9H3062
MAX gene-associated protein (MAX dimerization protein 5)MGA KIAA0518 MAD5Q8IWI92
MDS1 and EVI1 complex locus protein MDS1 (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)MECOM MDS1Q134652
Meckel syndrome type 1 proteinMKS1Q9NXB02
Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67)TMEM67 MKS3Q5HYA82
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)MED15 ARC105 CTG7A PCQAP TIG1 TNRC7Q96RN52
Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29)MED29 IXLQ9NX702
Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP)OPN1MW GCP; OPN1MW2P040012
Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)MATK CTK HYLP426792
Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)MCHR1 GPR24 SLC1Q997052
Melanoma-associated antigen 10 (Cancer/testis antigen 1.10) (CT1.10) (MAGE-10 antigen)MAGEA10 MAGE10P433632
Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)MAGEA3 MAGE3P433572
Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen)MAGEA4 MAGE4P433582
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