EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Membrane progestin receptor alpha (mPR alpha) (Progestin and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member VII)PAQR7 MRPAQ86WK92
Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)PGRMC2 DG6 PMBPO151732
Membrane-spanning 4-domains subfamily A member 15MS4A15Q8N5U12
Membrane-spanning 4-domains subfamily A member 3 (CD20 antigen-like protein) (Hematopoietic-specific transmembrane protein 4) (HTm4)MS4A3 CD20L HTM4Q96HJ52
Membrane-spanning 4-domains subfamily A member 6A (CD20 antigen-like 3) (Four-span transmembrane protein 3)MS4A6A 4SPAN3 CD20L3 MS4A6 CDA01 MSTP090Q9H2W12
Mesoderm induction early response protein 2 (Mi-er2)MIER2 KIAA1193Q8N3442
Mesoderm induction early response protein 3 (Mi-er3)MIER3Q7Z3K62
Mesoderm posterior protein 2 (Class C basic helix-loop-helix protein 6) (bHLHc6)MESP2 BHLHC6 SCDO2Q0VG992
Metabotropic glutamate receptor 5 (mGluR5)GRM5 GPRC1E MGLUR5P415942
Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Metalloprotease-related protein 1) (MPRP-1) (Overlapping with the m-AAA protease 1 homolog)OMA1 MPRP1Q96E522
Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5)MPPE1 PGAP5 PP579Q53F392
Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2)MPPED2 C11orf8 FAM1BQ157772
Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203Q8NFT22
Metallothionein-1B (MT-1B) (Metallothionein-IB) (MT-IB)MT1B MT1QP074382
Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV)MT4P479442
Methenyltetrahydrofolate synthase domain-containing proteinMTHFSDQ2M2962
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)MECP2P516082
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)MGMTP164552
Mevalonate kinase (MK) (EC 2.7.1.36)MVKQ034262
MFSD4 protein (Fragment)MFSD4Q96KX62
MHC class II antigenHLA-DPB1I4EC152
MICAL C-terminal-like protein (ERK2-binding testicular protein 1) (Ebitein-1)MICALCLQ6ZW332
MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)MICALL2 JRABQ8IY332
Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]MAP1A MAP1LP785592
Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP)MAP6 KIAA1878Q96JE92
Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)MAST3 KIAA0561O603072
Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)MTUS2 CAZIP KIAA0774 TIP150Q5JR592
Midasin (MIDAS-containing protein)MDN1 KIAA0301Q9NU222
Mirror-image polydactyly gene 1 proteinMIPOL1Q8TD102
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)MAVS IPS1 KIAA1271 VISAQ7Z4342
Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42)SLC25A42Q86VD72
Mitochondrial dimethyladenosine transferase 1 (Transcription factor B1, mitochondrial)TFB1M hCG_32337E5KTM52
Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1)MTFR2 DUFD1 FAM54AQ6P4442
Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)TIMM21 C18orf55 HSPC154 TIM21Q9BVV72
Mitochondrial inner membrane organizing system protein 1MINOS1 C1orf151Q5TGZ02
Mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit (NADH dehydrogenase (Ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), isoform CRA_b)NDUFS1 hCG_17250E5KRK52
Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1)MTG1 GTPBP7Q9BT172
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)MAPK10 JNK3 JNK3A PRKM10 SAPK1BP537792
Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)MAPK7 BMK1 ERK5 PRKM7Q131642
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)MAPK8 JNK1 PRKM8 SAPK1 SAPK1CP459832
Mitogen-activated protein kinase kinase kinase 19 (EC 2.7.11.1) (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4)MAP3K19 RCK YSK4Q56UN52
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)MAP3K8 COT ESTFP412792
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)MAP4K3 RAB8IPL1Q8IVH82
MLF2 protein (Myeloid leukemia factor 2) (Myeloid leukemia factor 2, isoform CRA_a) (cDNA, FLJ94652, Homo sapiens myeloid leukemia factor 2 (MLF2), mRNA)MLF2 hCG_25928Q5U0N12
MLN64 N-terminal domain homolog (STARD3 N-terminal-like protein)STARD3NL MENTHO UNQ855/PRO1864O957722
MOB kinase activator 2 (HCCA2) (Mob2 homolog) (Mps one binder kinase activator-like 2)MOB2 HCCA2Q70IA62
Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (MOCO1-B) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Molybdopterin-synthase large subunit) (MPT synthase large subunit)MOCS2 MCBPE MOCO1O960072
Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14)SLC16A14 MCT14Q7RTX92
Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)SLC16A9 C10orf36 MCT9Q7RTY12
Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member 10) (Progestin and adipoQ receptor family member X)MMD2 PAQR10Q8IY492
MORN repeat-containing protein 2 (MORN motif protein in testis)MORN2 MOPTQ502X02
Mth938 domain-containing protein (Adipogenesis associated Mth938 domain-containing protein)AAMDC C11orf67 PTD015Q9H7C92
Mucin-2 (MUC-2) (Intestinal mucin-2)MUC2 SMUCQ028172
Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter)ABCC1 MRP MRP1P335272
Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B)ABCC4 MRP4O154392
Multidrug resistance-associated protein 7 (ATP-binding cassette sub-family C member 10)ABCC10 MRP7 SIMRP7Q5T3U52
Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit)MMRN2 EMILIN3Q9H8L62
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)MEGF10 KIAA1780Q96KG72
Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11)MEGF11 KIAA1781 UNQ1949/PRO4432A6BM722
Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)MEGF8 C19orf49 EGFL4 KIAA0817Q7Z7M02
Muscarinic acetylcholine receptor M2CHRM2P081722
Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)MUSKO151462
Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR)MBNL3 CHCR MBLX39 MBXLQ9NUK02
MutS homolog 3 (E. coli)MSH3A1L4802
Myb-related protein B (B-Myb) (Myb-like protein 2)MYBL2 BMYBP102442
Myb/SANT-like DNA-binding domain-containing protein 2MSANTD2 C11orf61Q6P1R32
Myc target protein 1 (Myc target in myeloid cells protein 1)MYCT1 MTLC MTMC1Q8N6992
Myeloid cell nuclear differentiation antigenMNDAP412182
MYO1B variant protein (Myosin IB, isoform CRA_a)MYO1B hCG_25797B0I1S92
Myocyte-specific enhancer factor 2DMEF2DQ148142
Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2)MYF5 BHLHC2P133492
Myogenin (Class C basic helix-loop-helix protein 3) (bHLHc3) (Myogenic factor 4) (Myf-4)MYOG BHLHC3 MYF4P151732
Myopalladin (145 kDa sarcomeric protein)MYPN MYOPQ86TC92
Myosin light chain 5 (Myosin regulatory light chain 5) (Superfast myosin regulatory light chain 2) (MYLC2) (MyLC-2)MYL5Q020452
Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]MYLK MLCK MLCK1 MYLK1Q157462
Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)MYH13Q9UKX32
Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)MYH14 KIAA2034 FP17425Q7Z4062
Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)MYBPC1 MYBPCSQ008722
Myotonin-protein kinase0E5KR062
Myotubularin-related protein 11 (Cisplatin resistance-associated protein) (hCRA)MTMR11A4FU012
Myotubularin-related protein 13 (SET-binding factor 2)SBF2 CMT4B2 KIAA1766 MTMR13Q86WG52
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]AGAP209332
N-acetylated-alpha-linked acidic dipeptidase-like protein (NAALADase L) (EC 3.4.17.21) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase)NAALADL1 NAALADASEL NAALADLQ9UQQ12
N-acetylglutamate synthase, mitochondrial (EC 2.3.1.1) (Amino-acid acetyltransferase) [Cleaved into: N-acetylglutamate synthase long form; N-acetylglutamate synthase short form; N-acetylglutamate synthase conserved domain form]NAGSQ8N1592
N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase)NPL C1orf13Q9BXD52
N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP)RENBPP516062
N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)NAA25 C12orf30 MDM20 NAP1Q14CX72
N-alpha-acetyltransferase 60 (EC 2.3.1.48) (EC 2.3.1.88) (Histone acetyltransferase type B protein 4) (HAT4) (N-acetyltransferase 15) (NatF catalytic subunit)NAA60 HAT4 NAT15 UNQ2771/PRO7155Q9H7X02
N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP)FPR2 FPRH1 FPRL1 LXA4RP250902
N-myc-interactor (Nmi) (N-myc and STAT interactor)NMIQ132872
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)SLC9A3R2 NHERF2Q155992
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)PDZK1 CAP70 NHERF3 PDZD1Q5T2W12
Na+/K+-ATPase alpha 3 subunit variant (Fragment)0Q53ES02
NACHT, LRR and PYD domains-containing protein 1 (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain)NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1Q9C0002
NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)NLRP12 NALP12 PYPAF7 RNOP590462
NACHT, LRR and PYD domains-containing protein 8 (Nucleotide-binding oligomerization domain protein 16) (PYRIN and NACHT-containing protein 4)NLRP8 NALP8 NOD16 PAN4Q86W282
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]SIRT1 SIR2L1Q96EB62
NAD-dependent protein deacetylase sirtuin-6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6)SIRT6 SIR2L6Q8N6T72
NAD-dependent protein deacetylase sirtuin-7 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)SIRT7 SIR2L7Q9NRC82
NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (NADH oxidoreductase subunit MWFE) (ZNF183 protein)ZNF183 NDUFA1 hCG_23184Q6IBB52
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