EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
DTW domain-containing protein 2Dtwd2Q9D0U14
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3)Map2k3 Mkk3 Prkmk3O091104
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1)Map2k4 Jnkk1 Mek4 Mkk4 Prkmk4 Sek1 Serk1 Skk1P478094
Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48)Dusp7Q91Z464
DymeclinDymQ8CHY34
Dynein light chain 4, axonemalDnal4 Dnalc4Q9DCM44
Dyslexia-associated protein KIAA0319-like proteinKiaa0319lQ8K1354
E3 ubiquitin-protein ligase ARIH1 (EC 6.3.2.-) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein 77) (Ubiquitin-conjugating enzyme E2-binding protein 1)Arih1 Ari Ubch7bp Uip77Q9Z1K54
E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog)Dzip3 Kiaa0675Q7TPV24
E3 ubiquitin-protein ligase FANCL (EC 6.3.2.-) (Fanconi anemia group L protein homolog) (Proliferation of germ cells protein)Fancl Phf9 PogQ9CR144
E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1)Hace1 Kiaa1320Q3U0D94
E3 ubiquitin-protein ligase Itchy (EC 6.3.2.-)ItchQ8C8634
E3 ubiquitin-protein ligase makorin-1Mkrn1Q8C5V44
E3 ubiquitin-protein ligase MARCH7 (EC 6.3.2.-) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII)March7 AxotQ9WV664
E3 ubiquitin-protein ligase MARCH8 (EC 6.3.2.-) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII)March8 MirQ9DBD24
E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)Nedd4 Kiaa0093 Nedd-4 Nedd4-1 Nedd4aP469354
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 6.3.2.-)Peli1Q8C6694
E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 6.3.2.-)Pja1O551764
E3 ubiquitin-protein ligase RING2 (EC 6.3.2.-) (RING finger protein 1B) (RING1b) (RING finger protein 2)Rnf2 DinG Ring1bQ9CQJ44
E3 ubiquitin-protein ligase RNF6 (EC 6.3.2.-) (RLIM-like protein)Rnf6Q9DBU54
E3 ubiquitin-protein ligase SMURF1 (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)Smurf1Q9CUN64
E3 ubiquitin-protein ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)ToporsQ80Z374
E3 ubiquitin-protein ligase TRIP12 (EC 6.3.2.-) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)Trip12G5E8704
E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)Ubr2 Kiaa0349Q6WKZ84
Egl nine homolog 2 (EC 1.14.11.29) (Falkor) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)Egln2Q91YE24
Egl nine homolog 3 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3) (SM-20)Egln3Q91UZ44
EIG3 (EIG3 protein) (Late cornified envelope 3C) (Protein Lce3c) (Small proline rich-like 1)Lce3c Eig3 Sprrl1 mCG_120164Q91V054
Elongation factor 1-delta (EF-1-delta)Eef1dP577764
Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)Eef1gQ9D8N04
Elongator complex protein 2 (ELP2) (STAT3-interacting protein 1) (StIP1)Elp2 Statip1Q91WG44
Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)Neil3Q8K2034
Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (VEGF-induced aminopeptidase)Erap1 Appils Arts1Q9EQH24
Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)Erp44 Kiaa0573 Txndc4Q9D1Q64
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84 homolog)Ergic3 Erv46 Sdbcag84Q9CQE74
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)Eps15P425674
Epididymal secretory protein E1 (mE1) (Niemann Pick type C2 protein homolog)Npc2Q9Z0J04
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (Protein-tyrosine kinase MPK-6) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)Ddr1 Cak Eddr1 Mpk6Q031464
ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1)Emc10 Hsm1 Inm02Q3TAS64
ER membrane protein complex subunit 7Emc7 Orf3Q9EP724
ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein)Eri3 Pint1 Prnpip Prnpip1Q8C4604
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)Erlin2 Spfh2Q8BFZ94
Erythroid differentiation regulator 1Erdr1Q8VEL14
Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)Hsd17b8 H2-Ke6 Hke6P501714
ETS domain-containing transcription factor ERFErfP704594
ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor)Etv3 Mets Pe1Q8R4Z44
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)Eif1ax Eif1ayQ8BMJ34
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)Eif2s1 Eif2aQ6ZWX64
Eukaryotic translation initiation factor 2D (eIF2D) (Ligatin)Eif2d LgtnQ612114
Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25)Eif3k Eif3s12Q9DBZ54
Eukaryotic translation initiation factor 3 subunit L (eIF3l) (66 kDa tyrosine-rich heat shock protein) (67 kDa polymerase-associated factor) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) (HSP-66Y) (PAF67)Eif3l Eif3eip Eif3s6ip Paf67Q8QZY14
Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Novel APOBEC-1 target 1) (Translation repressor NAT1) (p97)Eif4g2 Nat1Q624484
Eukaryotic translation initiation factor 6 (eIF-6) (B4 integrin interactor) (CAB) (p27(BBP))Eif6 Itgb4bpO551354
Exocyst complex component 4 (Exocyst complex component Sec8)Exoc4 Sec8 Sec8l1O353824
Exonuclease 3'-5' domain-containing protein 2Exd2F8WID14
Exosome complex component RRP43 (Exosome component 8) (Ribosomal RNA-processing protein 43)Exosc8 Rrp43Q9D7534
Exostoses (Multiple)-like 3 (Exostosin-like 3)Extl3Q6P1H44
Exostosin-like 2 (EC 2.4.1.223) (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase)Extl2 Extr2Q9ES894
F-box only protein 30Fbxo30Q8BJL14
F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13)Fbxl13Q8CDU44
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)Fbxw11 Btrcp2 Fbw1b Fbxw1bQ5SRY74
FAST kinase domain-containing protein 5Fastkd5 Kiaa1792Q7TMV34
Fatty acid 2-hydroxylase (EC 1.-.-.-) (Fatty acid alpha-hydroxylase)Fa2h FaahQ5MPP04
Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) (Mammary-derived growth inhibitor) (MDGI)Fabp3 Fabph1P114044
FERM domain-containing protein 6Frmd6Q8C0V94
Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-5)Fgfrl1 Fgfr5Q91V874
Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell-specific gene 1 protein) (GSG1)Fank1Q9DAM94
Forkhead box protein O6Foxo6Q70KY44
Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form]Fxn FrdaO359434
Fumarylacetoacetate hydrolase domain-containing protein 2A (EC 3.-.-.-)Fahd2 Fahd2aQ3TC724
FYVE and coiled-coil domain-containing protein 1Fyco1Q8VDC14
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (C-JUN leucine zipper interactive protein JZA-3) (Thymine-DNA glycosylase)TdgP565814
Gamma-taxilin (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-responsive gene protein)Txlng LrgQ8BHN14
Gamma-tubulin complex component 4 (GCP-4)Tubgcp4 D2Ertd435e Gcp4Q9D4F84
General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)Gtf2e1Q9D0D54
Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)Ggps1Q9WTN04
Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)Glmn Fap48Q8BZM14
Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)Glud1 GludP264434
Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)Gpx3P464124
Glutathione S-transferase Mu 5 (EC 2.5.1.18) (Fibrous sheath component 2) (Fsc2) (GST class-mu 5)Gstm5 Fsc2 Gstm3P487744
Glutathione S-transferase P 2 (Gst P2) (EC 2.5.1.18) (GST YF-YF) (GST class-pi) (GST-piA)Gstp2 GstpiaP464254
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) (P90)Gpam Gpat1Q615864
Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) (Preimplantation protein 4)Gpcpd1 Gde5 Kiaa1434 Prei4Q8C0L94
Glycosyltransferase 8 domain-containing protein 1 (EC 2.4.1.-)Glt8d1Q6NSU34
Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1)Nmt1O703104
Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55)Gorasp2Q99JX34
Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7)Acbd3 Gcp60 Pap7Q8BMP64
GrancalcinGcaQ8VC884
Granzyme D (EC 3.4.21.-)GzmdP110334
GRB2-associated-binding protein 2 (Growth factor receptor bound protein 2-associated protein 2)Gab2Q3ZB574
Growth factor receptor-bound protein 14 (GRB14 adapter protein)Grb14Q9JLM94
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]GhrP168824
GrpE protein homolog 1, mitochondrial (Mt-GrpE#1)Grpel1Q99LP64
GSK3-beta interaction protein (GSKIP)GskipQ8BGR84
GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)Ran Rasl2-8P628274
Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain)Gngt1 Gng1Q610124
Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)Gna12 Gna-12P276004
H-2 class I histocompatibility antigen, D-37 alpha chainH2-T23P063394
H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)Nop10 Nola3Q9CQS24
HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1)Hax1 Hs1bp1O353874
Heat shock factor-binding protein 1Hsbp1Q9CQZ14
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