EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)Ppm1b Pp2c2 Pppm1bP369933
Protein Pira2Pira2F8VQ943
Protein Rabl2Rabl2E9Q9D53
Protein RCC2Rcc2 Kiaa1470Q8BK673
Protein RMD5 homolog ARmnd5aQ80YQ83
Protein Rsl1d1Rsl1d1Q8BVY03
Protein RTF2 homolog (Replication termination factor 2 domain-containing protein 1)Rtfdc1Q99K953
Protein S100-A4 (Metastasin) (Metastatic cell protein) (PEL98) (Placental calcium-binding protein) (Protein 18A2) (Protein Mts1) (S100 calcium-binding protein A4)S100a4 Capl Mts1P070913
Protein salvador homolog 1 (45 kDa WW domain protein) (mWW45)Sav1 Ww45 Wwp3Q8VEB23
Protein Samt3Samt3 1700072E05RikA2ARK73
Protein Sbf2Sbf2E9PXF83
Protein Scaf4 (Splicing factor, arginine/serine-rich 15)Scaf4 Sfrs15 Srsf15Q6PFF03
Protein Sf3b2 (Splicing factor 3b, subunit 2)Sf3b2 mCG_19856Q3UJB03
Protein Slc2a6 (Slc2a6 protein)Slc2a6A2AR263
Protein Speer2Speer2E9Q9U23
Protein Speer4dSpeer4dL7N2163
Protein SSUH2 homolog (Protein ssu-2 homolog)Ssuh2 Ssu2Q8C3L13
Protein syndesmos (NUDT16-like protein 1)Nudt16l1 SdosQ8VHN83
Protein TBRG4 (Transforming growth factor beta regulator 4)Tbrg4 Kiaa0948Q91YM43
Protein TCL1B5Tcl1b5P568453
Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)Tespa1Q3U1323
Protein TEX261 (Testis-expressed protein 261) (Testis-expressed sequence 261 protein)Tex261Q623023
Protein THEM6Them6Q80ZW23
Protein THEMIS (Grb2-associating protein) (Gasp) (Protein thylex) (Thymocyte-expressed molecule involved in selection)ThemisQ8BGW03
Protein Tpbpb (Trophoblast specific protein beta)TpbpbQ9CQC03
Protein transport protein Sec61 subunit gammaSec61gP600603
Protein Trim30dTrim30dE9PWL03
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)Ptp4a3 Prl3Q9D6583
Protein unc-45 homolog A (Unc-45A) (Stromal membrane-associated protein 1) (SMAP-1)Unc45a Smap1Q99KD53
Protein Vmn1r58 (Vomeronasal 1 receptor, D4)Vmn1r58 V1rd4 mCG_113912G3X9U33
Protein Wdfy1Wdfy1E9Q4P13
Protein YIPF2 (YIP1 family member 2)Yipf2Q99LP83
Protein Zfp655 (Zfp655 protein)Zfp655Q6P8W73
Protein Zfp658 (cDNA sequence BC043301)Zfp658 BC043301Q5PPQ43
Protein Zfp764Zfp764E9QAP13
Protein Zfp941 (cDNA sequence BC066028) (cDNA sequence BC066028, isoform CRA_b)Zfp941 BC066028 mCG_22593Q6NV923
Protein Zfp955a (Zinc finger protein 422, related sequence 1)Zfp955a Zfp422-rs1 Zfp955bQ80XR73
Protein-arginine deiminase type-2 (EC 3.5.3.15) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II)Padi2 Pdi Pdi2Q086423
Protein-cysteine N-palmitoyltransferase porcupine (mPORC) (EC 2.3.1.-)Porcn Porc PpnQ9JJJ73
Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase-2) (TGase-2)Tgm2P219813
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1Pcmtd1P599133
Protocadherin gamma B5Pcdhgb5Q91XX53
Protrudin (Zinc finger FYVE domain-containing protein 27)Zfyve27Q3TXX33
Proviral integration site 1Pim1Q8CFN83
Psychosine receptor (G-protein coupled receptor 65) (T-cell death-associated gene 8 protein)Gpr65 Gpcr25 Tdag8Q610383
Pumilio domain-containing protein KIAA0020Kiaa0020 D19Bwg1357eQ8BKS93
Pumilio homolog 1Pum1 Kiaa0099Q80U783
Putative deoxyribonuclease TATDN1 (EC 3.1.21.-)Tatdn1Q6P8M13
Putative GTP cyclohydrolase 1 type 2 Nif3l1 (EC 3.5.4.16) (GTP cyclohydrolase I) (NIF3-like protein 1)Nif3l1Q9EQ803
Putative helicase Mov10l1 (EC 3.6.4.13) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1)Mov10l1 ChampQ99MV53
Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1)Hkdc1Q91W973
Putative homeodomain transcription factor 2Phtf2Q8CB193
Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)Asxl2 Kiaa1685Q8BZ323
Putative ribosome-binding factor A, mitochondrialRbfaQ6P3B93
Putative uncharacterized proteinGbp7 Gbp6Q78UK83
Putative uncharacterized proteinFen1Q8C9523
Putative uncharacterized proteinTbc1d1Q3TGE93
Putative uncharacterized proteinZbtb4Q3UHT83
Putative uncharacterized proteinGfra2Q3UET63
Putative uncharacterized protein1520401A03RikQ8BXD23
Putative uncharacterized proteinCapgQ3TNN63
Putative uncharacterized proteinSiglechA0A4W83
Putative uncharacterized proteinSorcs1Q8BSV03
Putative uncharacterized protein (Fragment)Cald1Q3TUS13
Putative uncharacterized protein (Fragment)Nfs1Q9CTB23
Putative uncharacterized protein (Fragment)Oas1dQ3UXA23
Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74)Phospho2Q9D9M53
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)Pycr1Q922W53
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)Pdha1 Pdha-1P354863
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)Pdpr Kiaa1990Q7TSQ83
Pyruvate kinase (EC 2.7.1.40)PklrE9Q5093
Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog)Cryzl1Q921W43
Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein)Rph3al Gm1753 Noc2Q768S43
Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1)Gdi1 RabgdiaP503963
RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1)Gorab Ntklbp1 Scyl1bp1Q8BRM23
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta)Akt2Q608233
RAD52 motif-containing protein 1Rdm1Q9CQK33
Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)Rgl2 Rab2l RlfQ611933
Ran-binding protein 10 (RanBP10)Ranbp10 Kiaa1464Q6VN193
Rap guanine nucleotide exchange factor-like 1Rapgefl1Q68EF83
Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4)Rap1gap2 Garnl4 Kiaa1039 Rap1ga2Q5SVL63
Ras-like protein family member 11BRasl11bQ922H73
Ras-related and estrogen-regulated growth inhibitorRergQ8R3673
Ras-related GTP-binding protein B (Rag B) (RagB)RragbQ6NTA43
Ras-related protein Rab-24 (Rab-16)Rab24P352903
Ras-related protein Rab-25Rab25Q9WTL23
Ras-related protein Rab-27ARab27aQ9ERI23
Ras-related protein Rab-35Rab35Q6PHN93
Ras-related protein Rab-38Rab38Q8QZZ83
Ras-related protein Rab-43Rab43Q8CG503
Ras-related protein Rab-44Rab44Q8CB873
Ras-related protein Rab-6BRab6b D9Bwg0185eP612943
Ras-related protein Rab-7aRab7a Rab7P511503
RCC1 and BTB domain-containing protein 2 (Chromosome condensation 1-like) (Regulator of chromosome condensation and BTB domain-containing protein 2)Rcbtb2 Chc1lQ99LJ73
RE1-silencing transcription factor (Neural-restrictive silencer factor)Rest NrsfQ8VIG13
Receptor accessory protein 5, isoform CRA_a (Receptor expression-enhancing protein 5)Reep5 mCG_121499G3X8R03
Receptor activity-modifying protein 3Ramp3Q9WUP13
Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1) (TB2 protein-like 1)Reep6 Dp1l1 Tb2l1Q9JM623
Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)PtprgQ059093
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)Ptprk PtpkP358223
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