EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9)Slc26a9Q8BU913
Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog)Slc35f6Q8VE963
Solute carrier family 45 member 4Slc45a4 Kiaa1126Q0P5V93
Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 2 homolog) (PERV-A receptor 2 homolog) (Protein GPR172B) (Riboflavin transporter 1) (mRFT1)Slc52a2 Gpr172b Rft1Q9D8F33
Solute carrier organic anion transporter family member 1A4 (Sodium-independent organic anion-transporting polypeptide 2) (Solute carrier family 21 member 5)Slco1a4 Oatp1a4 Oatp2 Slc21a5Q9EP963
Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9)Slco2b1 Oatp2b1 Slc21a9Q8BXB63
Sorting nexin-12 (SDP8 protein)Snx12O704933
Sorting nexin-14Snx14Q8BHY83
Sorting nexin-27Snx27 Kiaa0488Q3UHD63
SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1)Inip Ssbip1Q3TXT33
SPARC-like protein 1 (Extracellular matrix protein 2) (Matrix glycoprotein Sc1)Sparcl1 Ecm2 Sc1P706633
Spectrin beta 1 (Spectrin beta 1, isoform CRA_b) (Spectrin beta chain, erythrocytic)Sptb Spnb1 mCG_123942Q3UGX23
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain)Sptbn1 Elf Spnb-2 Spnb2 Sptb2Q622613
Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein)Spatc1lQ9D9W03
Sperm equatorial segment protein 1Spesp1Q9D5A03
Sperm-associated antigen 11Spag11 Bin1b Ep2eQ8K4N23
Spermatid nuclear transition protein 1 (STP-1) (TP-1)Tnp1P108563
Spermatid-specific manchette-related protein 1 (Ciliated bronchial epithelial protein 1)Smrp1 Cbe1Q2MH313
Spermatogenesis-associated protein 16Spata16Q8C6363
Spermatogenesis-associated protein 19, mitochondrial (Spermatogenic cell-specific gene 1 protein) (Spergen-1)Spata19 Spergen1Q9DAQ93
Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase)Smpd1 AsmQ045193
Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Lysophospholipid receptor B4) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)S1pr5 Edg8 Lpb4Q91X563
Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)Sphk2Q9JIA73
Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52)Spice1 Ccdc52 D16Ertd480eQ8C8043
Splicing factor 3B subunit 1 (Splicing factor 3b, subunit 1)Sf3b1 mCG_117542G5E8663
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (Spliceosome-associated protein 130) (SAP 130)Sf3b3 Kiaa0017Q921M33
Splicing factor 3B subunit 4Sf3b4Q8QZY93
Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)Sf3b5 Sf3b10Q923D43
SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein homolog) (CLL deletion region gene 6 protein homolog)Spryd7 Clld6Q3TFQ13
SPRY domain-containing SOCS box protein 3 (SSB-3)Spsb3 Kiaa4204 Ssb3 Tce1Q571F53
Src substrate cortactinCttn Ems1Q605983
Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (mSLAP)Sla Slap Slap1Q608983
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]Srpk2O547813
StAR-related lipid transfer protein 6 (START domain-containing protein 6) (StARD6)Stard6P590963
STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein)Strada Lyk5 StradQ3UUJ43
Sterile alpha motif domain-containing protein 10 (SAM domain-containing protein 10)Samd10Q7TST33
Sterile alpha motif domain-containing protein 3 (SAM domain-containing protein 3)Samd3 Gm623Q8C4H23
Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (Transmembrane protein 66)Tmem66 SarafQ8R3Q03
Striatin-interacting protein 1 (Protein FAM40A)Strip1 Fam40a Kiaa1761Q8C0793
Stromal membrane-associated protein 1Smap1Q91VZ63
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (mSMC5) (Protein expressed in male leptotene and zygotene spermatocytes 453) (MLZ-453)Smc5 Kiaa0594 Smc5l1Q8CG463
Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)Tacr2 Tac2rP305493
Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (Succinate dehydrogenase subunit 5, mitochondrial)Sdhaf2 Pgl2 Sdh5Q8C6I23
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit)SdhdQ9CXV13
SUN domain-containing protein 2 (Protein unc-84 homolog B) (Sad1/unc-84 protein-like 2)Sun2 Unc84bQ8BJS43
Suppressor APC domain-containing protein 2 (Protein Ang)Sapcd2Q9D8183
Suppressor of cytokine signaling 7 (SOCS-7)Socs7 Cish7 Nap4Q8VHQ23
Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog)Ppan Ssf1Q91YU83
Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1)Smndc1 Smnr Spf30Q8BGT73
Synaptobrevin homolog YKT6 (EC 2.3.1.-)Ykt6Q9CQW13
Synaptojanin-2-binding protein (Activin receptor-interacting protein 2) (Activin receptor-interacting protein 4) (Mitochondrial outer membrane protein 25)Synj2bp Arip2 Omp25Q9D6K53
Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)Synrg Ap1gbp1 SyngQ5SV853
Syntaxin-8 (Syntaxin-like protein 3I35)Stx8O889833
T-cell surface glycoprotein CD3 eta chain (T-cell receptor T3 eta chain)Cd247 Cd3z TcrzP290203
T-cell-specific surface glycoprotein CD28 (CD antigen CD28)Cd28P310413
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon)Cct5 Ccte Kiaa0098P803163
T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta)Cct7 CcthP803133
T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta)Cct8 CctqP429323
T-lymphoma invasion and metastasis-inducing protein 1Tiam1E9Q1R73
TBC1 domain family member 20Tbc1d20Q9D9I43
TBC1 domain family member 22ATbc1d22a D15Ertd781eQ8R5A63
TBC1 domain family member 5Tbc1d5Q80XQ23
TBC1 domain family member 9BTbc1d9b Kiaa0676Q5SVR03
TCF3 fusion partner homolog (Protein FB1) (Protein amida)Tfpt AmidaQ3U1J13
Tctex1 domain-containing protein 2Tctex1d2Q9CQ663
Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog)Tshz1 Kiaa4206 Sdccag33 Tsh1Q5DTH53
Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog)Tep1 Tp1P974993
Testis-specific H1 histone (Haploid germ cell-specific nuclear protein 1) (Histone H1t2)H1fnt Hanp1Q8CJI43
Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1)Tsks Stk22s1O548873
Testisin (EC 3.4.21.-) (Serine protease 21) (Tryptase 4)Prss21Q9JHJ73
Tetraspanin-33 (Tspan-33) (Penumbra) (mPen) (Proerythroblast new membrane)Tspan33 PenQ8R3S23
Tetratricopeptide repeat protein 28 (TPR repeat protein 28)Ttc28 Kiaa1043 TprbkQ80XJ33
Tetratricopeptide repeat protein GNN (TPR repeat protein GNN) (Grp94-neighboring nucleotidase)GnnQ692V33
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)Tab1 Map3k7ip1Q8CF893
Thioredoxin (Trx) (ATL-derived factor) (ADF)Txn Txn1P106393
Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD)Txnl4a Dim1 Txnl4P838773
Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13)Tmx4 D2Bwg1356e Kiaa1162 Txndc13Q8C0L03
THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (REF1-I) (RNA and export factor-binding protein 1) (Transcriptional coactivator Aly/REF)Alyref Aly Ref1 Refbp1 THOC4O085833
THUMP domain-containing protein 3 (GtROSA26asSor)Thumpd3P977703
Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)Dtymk TmkP979303
TitinTtnE9Q8N13
Traf2 and NCK-interacting protein kinase (EC 2.7.11.1)Tnik Kiaa0551P835103
Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15)Trappc12 Ttc15Q8K2L83
Trafficking protein particle complex subunit 2 (Sedlin)Trappc2 SedlQ9CQP23
Trans-2-enoyl-CoA reductase, mitochondrial (EC 1.3.1.38)Mecr Nrbf1Q9DCS33
Transcobalamin-2 (TC-2) (Transcobalamin II) (TC II) (TCII)Tcn2O889683
Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog)Eny2Q9JIX03
Transcription cofactor vestigial-like protein 3Vgll3E9Q1Y13
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (mTCF-4)Tcf7l2 Tcf4Q924A03
Transcription factor A, mitochondrial (mtTFA) (Testis-specific high mobility group protein) (TS-HMG)Tfam HmgtsP406303
Transcription factor GATA-5 (GATA-binding factor 5)Gata5P974893
Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3 homolog) (KB-binding and recognition component) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Recombinant component) (Schnurri-3) (Zinc finger protein ZAS3)Hivep3 KBP1 Kiaa1555 Krc Rc shn3 Zas3A2A8843
Transcription factor jun-B (MyD21)Junb Jun-bP094503
Transcription factor SOX-12Sox12 Sox-12Q048903
Transcriptional adapter 1 (Transcriptional adapter 1-like protein)Tada1 Tada1lQ99LM93
Transcriptional enhancer factor TEF-5 (DTEF-1) (ETF-related factor 1) (ETFR-1) (TEA domain family member 3) (TEAD-3)Tead3 Tcf13r2 Tef5P702103
Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein)Ctcfl BorisA2APF33
Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg-1)Tle1 Grg1Q624403
Transformer-2 protein homolog alphaTra2aE9QP003
Transgelin-2 (SM22-beta)Tagln2 Kiaa0120Q9WVA43
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