EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Vang-like protein 1 (Loop-tail protein 2) (Van Gogh-like protein 1)Vangl1 Lpp2Q80Z963
Vesicle transport protein USE1 (Protein D12) (USE1-like protein)Use1 Use1lQ9CQ563
Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)Vti1a Vti1 Vti1l2O891163
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)Vamp3 Syb3P630243
Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2)Sec22a Sec22l2Q8BH473
Vesicular, overexpressed in cancer, prosurvival protein 1 (EGFR-coamplified and overexpressed protein) (ECop)Vopp1 EcopQ8R1C33
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (mVDAC3) (Outer mitochondrial membrane protein porin 3)Vdac3Q609313
Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Stargazin) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2)Cacng2 StgO886023
Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5)Cacng5Q8VHW43
Voltage-dependent calcium channel subunit alpha-2/delta-2 (Protein ducky) (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]Cacna2d2 Kiaa0558Q6PHS93
Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1) (Kv-beta-1)Kcnab1 Kvb1P631433
von Willebrand factor A domain-containing protein 5B2Vwa5b2Q3UR503
von Willebrand factor A domain-containing protein 8Vwa8 Kiaa0564Q8CC883
WASH complex subunit FAM21Fam21 D6Wsu116e Kiaa0592Q6PGL73
WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B)Wdr45b Wdr45l Wipi3Q9CR393
WW domain-binding protein 11 (WBP-11) (Splicing factor that interacts with PQBP-1 and PP1)Wbp11 Sipp1Q923D53
X-linked lymphocyte-regulated protein PM1XlrP055313
X-linked retinitis pigmentosa GTPase regulator (mRpgr)RpgrQ9R0X53
YTH domain family protein 3Ythdf3Q8BYK63
YY1-associated factor 2Yaf2Q99LW63
Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Zinc finger protein 238) (Zfp-238)Zbtb18 Rp58 Zfp238 Znf238Q9WUK63
Zinc finger and BTB domain-containing protein 3Zbtb3Q91X453
Zinc finger and BTB domain-containing protein 5 (Transcription factor ZNF-POZ)Zbtb5 Kiaa0354Q7TQG03
Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon)Zbtb7a Lrf Zbtb7O889393
Zinc finger and SCAN domain-containing protein 21 (CtFIN51) (Transcription factor RU49) (Zinc finger protein 38) (Zfp-38)Zscan21 Zfp-38 Zfp38 Zipro1 Znf38Q072313
Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)Zc3h18 Nhn1Q0P6783
Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13)Zc3hav1Q3UPF53
Zinc finger CCHC domain-containing protein 24Zcchc24B2RVL63
Zinc finger protein 131Znf131 Zfp131Q8K3J53
Zinc finger protein 143 (Zfp-143) (Selenocysteine tRNA gene transcription-activating factor) (mStaf)Znf143 Staf Zfp143O702303
Zinc finger protein 318 (Testicular zinc finger protein) (Fragment)Znf318 Tzf Zfp318Q99PP23
Zinc finger protein 394 (Zinc finger protein 94) (Zfp-94) (Zinc finger protein with KRAB and SCAN domains 14)Znf394 Zfp94 Zfp99 Zkscan14Q9Z1D93
Zinc finger protein 503 (Zinc finger protein Nolz-1)Znf503 Nolz1 Zfp503Q7TMA23
Zinc finger protein 59Zfp59F8VPX43
Zinc finger protein 593 (Zinc finger protein T86)Znf593 Zfp593Q9DB423
Zinc finger protein 654Znf654 Zfp654Q9DAU93
Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog)Dzip1 Kiaa0996Q8BMD23
Zinc finger protein Pegasus (Ikaros family zinc finger protein 5)Ikzf5 Zfpn1a5 Znfn1a5Q8BU003
Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein)Plag1Q9QYE03
Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5)Zic5 OprQ7TQ403
Zinc finger RNA-binding proteinZfrO885323
Zinc finger ZZ-type and EF-hand domain-containing protein 1Zzef1 Kiaa0399Q5SSH73
Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (mZIP1)Slc39a1 Zip1 ZirtlQ9QZ033
Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11)Slc39a11 Zip11Q8BWY73
Zymogen granule membrane protein 16 (Zymogen granule protein 16) (Secretory lectin ZG16)Zg16Q8K0C53
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)Pdk1Q8BFP93
1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member E1) (Aldo-keto reductase family 1 member E2)Akr1e2 Akr1cl2 Akr1e1Q9DCT12
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 3) (1-AGP acyltransferase 3) (1-AGPAT 3) (Lysophosphatidic acid acyltransferase gamma) (LPAAT-gamma)Agpat3Q9D5172
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)Eftud2 Snrp116O088102
14-3-3 protein theta (14-3-3 protein tau)YwhaqP682542
2'-5' oligoadenylate synthetase 1E (MCG142506, isoform CRA_a) (Protein Oas1e)Oas1e mCG_142506Q8C2W32
2'-5'-oligoadenylate synthase-like protein 2 (EC 2.7.7.84) (54 kDa 2'-5'-oligoadenylate synthase-like protein) (p54 OASL) (M1204)Oasl2Q9Z2F22
2-acylglycerol O-acyltransferase 2 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 1-like) (Monoacylglycerol O-acyltransferase 2)Mogat2 Dgat2l5 Mgat1lQ80W942
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-)Ogfod2Q9CQ042
2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)Ogdh Kiaa4192Q605972
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (Branched chain ketoacid dehydrogenase E1, alpha polypeptide)Bckdha mCG_7651Q3U3J12
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)BckdhbQ6P3A82
26S protease regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (CIP21) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)Psmc4 Tbp7P547752
26S protease regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1)Psmc5 Sug1P621962
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97)Psmd2Q8VDM42
26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B)Psmd5 Kiaa0072Q8BJY12
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (p42A)Psmd6Q99JI42
28S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (28S ribosomal protein S18-3, mitochondrial) (MRP-S18-3)Mrps18aQ99N852
28S ribosomal protein S2, mitochondrial (MRP-S2) (S2mt)Mrps2Q924T22
28S ribosomal protein S21, mitochondrial (MRP-S21) (S21mt)Mrps21 Rpms21P580592
28S ribosomal protein S26, mitochondrial (MRP-S26) (S26mt)Mrps26Q80ZS32
28S ribosomal protein S34, mitochondrial (MRP-S34) (S34mt) (T-complex expressed gene 2 protein)Mrps34 Tce2Q9JIK92
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)HmgcrQ012372
3-keto-steroid reductase (EC 1.1.1.270) (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62)Hsd17b7O887362
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase)OxsmQ9D4042
39S ribosomal protein L38, mitochondrial (L38mt) (MRP-L38)Mrpl38Q8K2M02
39S ribosomal protein L43, mitochondrial (Mitochondrial ribosomal protein L43)Mrpl43 mCG_16934Q5RL202
39S ribosomal protein L52, mitochondrial (L52mt) (MRP-L52)Mrpl52Q9D0Y82
4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC 1.2.1.47) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3)Aldh9a1Q9JLJ22
40S ribosomal protein S23Rps23P622672
43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein)RapsnP126722
5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)Nt5c Dnt1Q9JM142
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)Prkaa1Q5EG472
5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73)Nt5e Nt5 NteQ615032
5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (5-HT-1E-beta) (Serotonin receptor 1F)Htr1f 5ht1f Htr1ebQ022842
60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2)Trove2 Ssa2O088482
60S ribosomal protein L26 (Silica-induced gene 20 protein) (SIG-20)Rpl26P612552
60S ribosomal protein L30Rpl30P628892
60S ribosomal protein L7-like 1Rpl7l1Q9D8M42
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-)Adamts1P978572
A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)Akap8 Akap95Q9DBR02
A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein)Sphkap Kiaa1678Q6NSW32
A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (mMYH)Mutyh MyhQ99P212
Abhydrolase domain-containing protein 15 (EC 3.1.1.-)Abhd15Q5F2F22
Abhydrolase domain-containing protein 8 (EC 3.-.-.-)Abhd8Q8R0P82
Acetyl-Coenzyme A acetyltransferase 3 (Protein Acat3)Acat3Q80X812
Acetylcholine receptor subunit betaChrnb1 AcrbP096902
Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2)Ablim2Q8BL652
Actin-binding protein anillinAnlnQ8K2982
Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpN-alpha) (ArpNa) (BRG1-associated factor 53B) (BAF53B)Actl6b Actl6 Arpna Baf53bQ99MR02
Actin-like protein 7A (Actin-like-7-alpha) (Testis-specific actin-2) (T-actin-2)Actl7a Tact2Q9QY842
Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Sid 329)Arpc1a Sid329Q9R0Q62
Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4)Trip4Q9QXN32
Active breakpoint cluster region-related proteinAbrQ5SSL42
Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP)Rps19bp1 ArosQ8C6B92
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