EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) (Tyrosine kinase-associated leucine zipper protein LAZip)Crebzf ZfQ91ZR32
CST complex subunit CTC1 (Alpha-accessory factor of 132 kDa) (AAF-132) (AAF132) (Conserved telomere maintenance component 1)Ctc1Q5SUQ92
CST complex subunit STN1 (Alpha-accessory factor of 44 kDa) (AAF-44) (AAF44) (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog)Obfc1 Stn1Q8K2X32
cTAGE family member 5Ctage5E9PY902
CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-)Ctdspl2 D2Ertd485eQ8BG152
CUE domain-containing protein 1Cuedc1Q8R3V62
Cullin-2 (CUL-2)Cul2Q9D4H82
Cullin-3 (CUL-3)Cul3Q9JLV52
Cullin-4B (CUL-4B)Cul4b mKIAA0695A2A4322
CXADR-like membrane protein (Adipocyte adhesion molecule) (Adipocyte-specific protein 5) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein)Clmp Acam Asam Asp5Q8R3732
CXXC-type zinc finger protein 4Cxxc4M0QWU02
CXXC-type zinc finger protein 5Cxxc5Q91WA42
Cyclic AMP-responsive element-binding protein 3Creb3Q3UNH62
Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]Creb3l3 CrebhQ91XE92
Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1)Cdk14 Kiaa0834 Pftk1O354952
Cyclin-dependent kinase 2-interacting proteinCinpQ9D0V82
Cyclin-dependent kinase-like 1 (EC 2.7.11.22)Cdkl1Q8CEQ02
Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine-protein kinase KKIAMRE)Cdkl2 Kkiamre KkmQ9QUK02
Cyclin-L2 (Cyclin Ania-6b) (Paneth cell-enhanced expression protein) (PCEE)Ccnl2 Ania6b MNCb-5160Q9JJA72
Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase)CthQ8VCN52
Cystatin 10 (Chondrocytes) (DD72 protein) (Protein Cst10)Cst10 DD72Q9JM842
Cysteine and tyrosine-rich protein 1 (Proline-rich domain-containing protein)Cyyr1Q8VIH72
Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagin-1) (Autophagy-related cysteine endopeptidase 1) (Autophagy-related protein 4 homolog B)Atg4b Apg4b Autl1 Kiaa0943Q8BGE62
Cysteine-rich DPF motif domain-containing protein 1Cdpf1Q8R3A22
Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3)CriptO703332
Cytidine and dCMP deaminase domain-containing protein 1Cdadc1Q8BMD52
Cytochrome b reductase 1 (EC 1.-.-.-) (Duodenal cytochrome b)Cybrd1 DcytbQ925G22
Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)CybaQ614622
Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)Uqcrc1Q9CZ132
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrialCox16Q9CR632
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)Cox4i1 Cox4 Cox4aP197832
Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver)Cox6a1 Cox6alP430242
Cytochrome c oxidase subunit 7C, mitochondrial (Cytochrome c oxidase polypeptide VIIc)Cox7c Cox7c1P176652
Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7-alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase)Cyp2a12P565932
Cytochrome P450 2S1 (EC 1.14.14.1) (CYPIIS1)Cyp2s1Q9DBX62
Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3) (CLM3) (SEC7 homolog C) (mSec7-3)Cyth3 Grp1 Pscd3O089672
Cytokine receptor-like factor 1 (Cytokine receptor-like molecule 3) (CRLM-3) (Cytokine-like factor 1) (CLF-1) (Novel cytokine receptor 6) (NR6)Crlf1 Crlm3Q9JM582
Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)Aco1 Ireb1 IrebpP282712
Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)Dync1h1 Dhc1 Dnch1 Dnchc1 DyhcQ9JHU42
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)Dync1i2 Dnci2 Dncic2O884872
Cytoplasmic polyadenylated homeobox (Homeobox protein ESO1) (Protein Cphx1) (Protein Cphx3)Eso1 Cphx Cphx1 Cphx3Q8BX392
Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (mCPEB-4)Cpeb4 Kiaa1673Q7TN982
Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1)Nck1Q99M512
Cytoskeleton-associated protein 2-likeCkap2lQ7TS742
Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1)Agtpbp1 Ccp1 Nna1Q641K12
Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3)Agbl3 Ccp3Q8CDP02
Cytosolic Fe-S cluster assembly factor NUBP1 (Nucleotide-binding protein 1) (NBP 1)Nubp1Q9R0602
DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs) (Zinc finger protein-associated with nuclear matrix of 75 kDa)Znf326 Zan75 Zfp326 ZirdO882912
DCN1-like protein 2 (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)Dcun1d2 Dcun1l2Q8BZJ72
DCN1-like protein 4 (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)Dcun1d4Q8CCA02
DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)Dcaf10 Wdr32A2AKB92
DDB1- and CUL4-associated factor 17Dcaf17Q3TUL72
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)Dcaf8 D1Ucla4 H326 Wdr42aQ8N7N52
DEAH (Asp-Glu-Ala-His) box polypeptide 16, isoform CRA_a (Protein Dhx16)Dhx16 mCG_141148G3X8X02
DEAH (Asp-Glu-Ala-His) box polypeptide 35 (DEAH (Asp-Glu-Ala-His) box polypeptide 35, isoform CRA_a) (Protein Dhx35)Dhx35 mCG_114772Q8K1G92
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)Dock1Q8BUR42
Dedicator of cytokinesis protein 4Dock4 Kiaa0716P597642
Dedicator of cytokinesis protein 9Dock9E9QMR22
Dehydrodolichyl diphosphate synthase (Dedol-PP synthase) (EC 2.5.1.-) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase)DhddsQ99KU12
Deleted in azoospermia-like (DAZ-like autosomal) (Deleted in azoospermia-like 1)Dazl Dazl1 DazlaQ643682
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)Aldh4a1Q8CHT02
Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]Aldh18a1 P5cs PycsQ9Z1102
DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn)Dennd1aQ8K3822
DENN domain-containing protein 2ADennd2aQ8C4S82
Deoxyribonuclease-2-beta (EC 3.1.22.1) (DNase II-like acid DNase) (DNase2-like acid DNase) (Deoxyribonuclease II beta) (DNase II beta) (Endonuclease DLAD)Dnase2b DladQ9QY482
Deoxyuridine triphosphatase, isoform CRA_b (Dutp protein) (Protein Dut)Dut Dutp mCG_6136Q8VCG12
Dermokine (Epidermis-specific secreted protein SK30/SK89)DmknQ6P2532
Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Protein FAM152B)Desi1 D15Wsu75e Fam152b Pppde2Q9CQT72
Desumoylating isopeptidase 2 (DeSI-2) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)Desi2 Fam152a Pppde1Q9D2912
DIA3 (Protein diaphanous homolog 2)Diap2Q6W4W72
Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)Diablo SmacQ9JIQ32
Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1)Sat1 SatP480262
Diffuse panbronchiolitis critical region protein 1 homologDpcr1 Gm630Q3TNW52
Dimethylaniline monooxygenase [N-oxide-forming] (EC 1.14.13.8)Fmo9Q8C1162
Dimethylglycine dehydrogenase, mitochondrial (EC 1.5.8.4) (ME2GLYDH)DmgdhQ9DBT92
Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)Dpp9Q8BVG42
DIS3-like exonuclease 1 (EC 3.1.13.-)Dis3l Kiaa1955Q8C0S12
Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Thymic epithelial cell-ADAM) (TECADAM)Adam28Q9JLN62
Disintegrin and metalloproteinase domain-containing protein 29 (MCG61645)Adam29 mCG_61645G3X9B52
Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)Dlgap1 Kiaa4162Q9D4152
Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)Dlgap2 Dap2Q8BJ422
Disrupted in renal carcinoma protein 2 homologDirc2Q8BFQ62
DNA damage-inducible transcript 4 protein (Dexamethasone-induced gene 2 protein) (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)Ddit4 Dig2 Redd1 Rtp801Q9D3F72
DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Soleus muscle atrophied after hindlimb suspension protein 1)Ddit4l Rtp801l Smhs1Q8VHZ52
DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator)Dram1 DramQ9DC582
DNA excision repair protein ERCC-1Ercc1 Ercc-1P079032
DNA helicase B (EC 3.6.4.12)HelbQ6NVF42
DNA ligase (EC 6.5.1.1)Lig3 mCG_8187Q80ZH72
DNA polymerase delta catalytic subunit (EC 2.7.7.7)Pold1P524312
DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase kappa)Poll PolkQ9QXE22
DNA repair protein complementing XP-C cells homolog (Xeroderma pigmentosum group C-complementing protein homolog) (p125)XpcP516122
DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3)Rad51d R51h3 Rad51l3O552302
DNA repair protein RAD52 homologRad52P433522
DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4)Xrcc4Q924T32
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3)Mcm3 Mcmd Mcmd3P252062
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)Top1 Top-1Q047502
DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)Dedd2 Flame3Q8QZV02
DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)Satb1Q606112
DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase)Polm polmuQ9JIW42
DNA-directed RNA polymerase I subunit RPA12 (Zinc ribbon domain-containing protein 1)Znrd1 Rpa12Q791N72
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