EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)Itgb3O548901
Integrin beta-like protein 1Itgbl1Q8VDV01
Integrin-alpha FG-GAP repeat-containing protein 2Itfg2Q91WI71
Intelectin-1a (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor)Itln1 Intl Itln Itln1a ItlnaO883101
Intelectin-1b (Intelectin-2)Itln1b Itln2 ItlnbQ80ZA01
Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2)Itih2Q617031
Interactor protein for cytohesin exchange factors 1Ipcef1 Kiaa0403Q5DU311
Interferon alpha 11 (Interferon alpha-11)Ifna11 Ifna6Q810G41
Interferon alpha-2 (MCG123693)Ifna2 mCG_123693B1AYH71
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1)Ifnar1 Ifar IfnarP338961
Interferon gamma (IFN-gamma)IfngP015801
Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 6.3.2.-)Irf2bp1Q8R3Y81
Interferon regulatory factor 7 (IRF-7)Irf7P704341
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (Glucocorticoid-attenuated response gene 49 protein) (GARG-49) (P49) (IRG2)Ifit3 Garg49 Ifi49 Isg49Q643451
Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)Ifitm3Q9CQW91
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (RAX) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)Prkra RaxQ9WTX21
Interferon-related developmental regulator 1 (Nerve growth factor-inducible protein PC4) (TPA-induced sequence 7) (TIS7 protein)Ifrd1 Tis7P191821
Interferon-related developmental regulator 2 (Protein Ifrd2)Ifrd2 mCG_18874Q9D8U01
Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-)Isg20l2Q3U1G51
Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Promyelocytic leukemia nuclear body-associated protein ISG20) (Protein DnaQL)Isg20Q9JL161
Interleukin 10 receptor 2 (Interleukin 10 receptor, beta) (Interleukin 10 receptor, beta, isoform CRA_a) (Interleukin-10 receptor subunit beta)Il10rb Il10r2 mCG_11439Q8VHM71
Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)Ilf2 Nf45Q9CXY61
Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (IL1 inhibitor)Il1rn Il-1raP250851
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1)Irak4Q8R4K21
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) (mu-IRAK-2)Irak2Q8CFA11
Interleukin-1 receptor-like 2 (IL-36 receptor) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2)Il1rl2Q9ERS71
Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)Il17a Ctla8 Il17Q623861
Interleukin-17B (IL-17B) (Cytokine CX1) (Cytokine-like protein ZCYTO7) (Neuronal interleukin-17-related factor)Il17b Nirf Zcyto7Q9QXT61
Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (IL-20R1)Il20raQ6PHB01
Interleukin-22b (IL-22b) (IL-10-related T-cell-derived-inducible factor beta) (IL-TIF beta) (IL-TIFb)Il22b IltifbQ9JJY81
Interleukin-23 receptor (IL-23 receptor) (IL-23R)Il23rQ8K4B41
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CD antigen CD125)Il5ra Il5rP211831
Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4)Habp4Q9JKS51
Intraflagellar transport protein 46 homologIft46Q9DB071
Intron-binding protein aquariusAqr Kiaa0560Q8CFQ31
Inversin (Inversion of embryo turning protein) (Nephrocystin-2)Invs Inv Nphp2O890191
Inverted formin-2Inf2Q0GNC11
IQ and AAA domain-containing protein 1-like (Protein IQCA1P1)Iqca1p1 Iqca1lA6H6901
IQ domain-containing protein DIqcdQ9D3V11
IQ domain-containing protein EIqceQ6PCQ01
IQ motif and SEC7 domain-containing protein 2Iqsec2 Kiaa0522Q5DU251
Iron-sulfur protein NUBPL (Nucleotide-binding protein-like)NubplQ9CWD81
Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1)Irx1 Irxa1P810681
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)Idh3gP704041
Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)Iars2Q8BIJ61
Izumo sperm-egg fusion protein 4Izumo4D3Z6901
JmjC domain-containing protein 8 (Jumonji domain-containing protein 8)Jmjd8Q3TA591
Junction-mediating and -regulatory proteinJmyQ9QXM11
Juxtaposed with another zinc finger protein 1Jazf1Q80ZQ51
Kallikrein 1-related peptidase b21 (EC 3.4.21.35) (Glandular kallikrein K21) (mGK-21) (Tissue kallikrein 21)Klk1b21 Klk-21 Klk21Q617591
Kallikrein 1-related peptidase-like b4 (7S nerve growth factor alpha chain) (Alpha-NGF)Klk1b4 Klk-4 Klk4 NgfaP007571
Kallikrein-7 (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (Thymopsin)Klk7 Prss6 ScceQ91VE31
Kappa-type opioid receptor (K-OR-1) (KOR-1) (MSL-1)Oprk1P335341
KAT8 regulatory NSL complex subunit 1 (NSL complex protein NSL1) (Non-specific lethal 1 homolog)Kansl1 Kiaa1267 Nsl1Q80TG11
Katanin p60 ATPase-containing subunit A1Katna1E9PZI61
KDEL motif-containing protein 1 (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58)Kdelc1 Ep58Q9JHP71
Kelch domain containing 4, isoform CRA_a (Kelch domain-containing protein 4)Klhdc4 mCG_14165G3X9611
Kelch repeat and BTB domain-containing protein 12 (Kelch domain-containing protein 6)Kbtbd12 Klhdc6Q9D6181
Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4)Kbtbd4 Bklhd4Q8R1791
Kelch-like 5 (Drosophila), isoform CRA_a (Klhl5 protein) (Protein Klhl5)Klhl5 mCG_10265Q6PFE11
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2)Keap1 Inrf2 Kiaa0132Q9Z2X81
Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)Klhl42 Kiaa1340 Klhdc5Q8BFQ91
Kelch-like protein 7Klhl7Q8BUL51
Keratin associated protein 1-5 (Protein Krtap1-5)Krtap1-5A2A5901
Keratin associated protein 4-7 (Protein Krtap4-7)Krtap4-7Q9D7321
Keratin, type I cytoskeletal 24 (Cytokeratin-24) (CK-24) (Keratin-24) (K24) (Type I keratin-24)Krt24 Ka24A1L3171
Keratin, type I cytoskeletal 28 (Cytokeratin-28) (CK-28) (Keratin-25D) (K25D) (Keratin-28) (K28) (Type I inner root sheath-specific keratin-K25irs4)Krt28 Krt25dA6BLY71
Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Cytoskeletal 57 kDa keratin) (Keratin-4) (K4) (Type-II keratin Kb4)Krt4 Krt2-4P077441
Keratin-associated protein 5-2Krtap5-2Q9D5Z71
Keratinocyte-associated transmembrane protein 2Kct2Q8K2011
Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein)Fn3krpQ8K2741
Killer cell lectin-like receptor 7 (Lymphocyte antigen 49g) (Ly-49g) (T-cell surface glycoprotein Ly-49G)Klra7 Ly-49g Ly49-g Ly49g Ly49g4Q606541
Killer cell lectin-like receptor subfamily B member 1A (NKR-P1A) (CD161 antigen-like family member A) (Lymphocyte antigen 55A) (Ly-55A) (NKR-P1.7) (Natural killer cell surface protein P1-2) (NKR-P1 2) (CD antigen CD161a)Klrb1a Ly55 Ly55a Nkrp1aP278111
Killer cell lectin-like receptor subfamily B member 1B allele B (CD161 antigen-like family member B) (Inhibitory receptor NKR-P1B) (Lymphocyte antigen 55d) (Ly-55d) (NKR-P1D) (Natural killer cell surface protein NKR-P1B allele B6) (CD antigen CD161b)Klrb1b Klrb1d Ly55d Nkrp1b Nkrp1dQ99JB41
Killer cell lectin-like receptor subfamily B member 1F (CD161 antigen-like family member F) (Natural killer cell surface protein NKR-P1F) (CD antigen CD161f)Klrb1f Nkrp1fQ8VD981
Killer cell lectin-like receptor, subfamily A, member 15 (Lectin-related NK cell receptor Ly49) (Lectin-related NK cell receptor Ly49O)Klra15Q9JHH81
Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5)Kif11Q6P9P61
Kinesin-like protein KIF2A (Kinesin-2)Kif2a Kif2 Kns2P287401
Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK)Kif2cQ922S81
Kinesin-like protein KIF3CKif3cO350661
Kinesin-like protein KIFC3Kifc3O352311
Kinetochore protein Spc25Spc25 Spbc25Q3UA161
Kinetochore-associated protein DSN1 homologDsn1Q9CYC51
KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25)Kank2 Ankrd25Q8BX021
KRAB-containing zinc-finger protein KRAZ1 (Protein Zfp53) (Zinc finger protein 53) (Zinc finger protein 53, isoform CRA_b)Zfp53 KRAZ1 Zfp118 mCG_67976Q9Z1171
Krueppel-like factor 15 (Cardiovascular Krueppel-like factor)Klf15 CklfQ9EPW21
Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)Klf5 Bteb2 IklfQ9Z0Z71
Krueppel-like factor 7Klf7Q99JB01
Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)Kcnip4 Calp Kchip4Q6PHZ81
L-threonine aldolase (Protein Tha1)Tha1 Gly1Q6XPS71
L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase)DcxrQ91X521
Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)Lctl KlphQ8K1F91
Lamina-associated polypeptide 2, isoforms alpha/zeta (Thymopoietin isoforms alpha/zeta) (TP alpha/zeta)Tmpo Lap2Q610331
Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha)Lama1 Lama Lama-1P191371
Laminin subunit beta-1Lamb1E9QN701
Laminin subunit gamma-1Lamc1F8VQJ31
Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Solute carrier family 43 member 1)Slc43a1 Lat3Q8BSM71
Large subunit GTPase 1 homolog (EC 3.6.1.-)Lsg1 D16Bwg1547eQ3UM181
Late cornified envelope 1B (Protein Lce1b) (Small proline rich-like 5)Lce1b Sprrl5 mCG_119399Q9D1491
Late cornified envelope 1M (Late cornified envelope 5A) (Protein Lce1m)Lce1m Lce5a mCG_141032Q9CR911
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