EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ras-related protein Ral-ARala Ral Ral-aP633211
Ras-related protein Rap-1b (GTP-binding protein smg p21B)Rap1bQ99JI61
Ras-related protein Rap-2aRap2aQ80ZJ11
Ras-related protein Rap-2cRap2cQ8BU311
Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)Ralgps2Q9ERD61
RBPJ-interacting and tubulin-associated proteinRitaQ9D1H01
RCC1 domain-containing protein 1Rccd1Q8BTU71
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP)Ripk1 Rinp RipQ608551
Receptor-transporting protein 3 (Transmembrane protein 7)Rtp3 Tmem7Q5QGU61
Receptor-transporting protein 4 (28 kDa interferon-responsive protein)Rtp4 Ifrg28Q9ER801
Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)PtprdQ644871
Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)Ptprm Kiaa4044P288281
Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Islet of Langerhans regenerating protein 3) (Lithostathine 3) (Pancreatitis-associated protein 2) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form]Reg3a Pap2O090371
Regenerating islet-derived protein 3-beta (REG-3-beta) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-beta) (Reg III-beta) [Cleaved into: Regenerating islet-derived protein 3-beta 16.5 kDa form; Regenerating islet-derived protein 3-beta 15 kDa form]Reg3b Pap Pap1P352301
Regulator of G-protein signaling 19 (RGS19)Rgs19Q9CX841
Regulator of G-protein signaling 9 (RGS9)Rgs9O548281
Regulatory-associated protein of mTORRptor 4932417H02Rik mCG_15044A2ACM01
REM2- and Rab-like small GTPase 1Rsg1 Gm723A2A8251
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)Rfc5Q9D0F61
Repressor of RNA polymerase III transcription MAF1 homologMaf1Q9D0U61
Reprimo-like proteinRprmlQ3URD21
RetbindinRtbdnQ8QZY41
Reticulocalbin-1Rcn1 Rca1 RcnQ051861
Reticulon-4-interacting protein 1, mitochondrial (NOGO-interacting mitochondrial protein)Rtn4ip1 NimpQ924D01
Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP)Abca4 AbcrO356001
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)Rbl1Q647011
Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)Rxrg Nr2b3P287051
Retrograde Golgi transport protein RGP1 homologRgp1 Kiaa0258Q8BHT71
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (GDI-1) (Rho-GDI alpha)Arhgdia C87222 Gdi1Q99PT11
Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)Arhgap15Q811M11
Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)Arhgap21 Arhgap10 Kiaa1424Q6DFV31
Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)Arhgap23 Kiaa1501 MNCb-1301Q69ZH91
Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24)Arhgap24Q8C4V11
Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)Arhgap31 Cdgap Kiaa1204A6X8Z51
Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1)Arhgap35 Grlf1,Kiaa1722Q91YM21
Rho GTPase-activating protein 39Arhgap39 D15Wsu169e Kiaa1688P592811
Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF)Arhgef10l Kiaa1626A2AWP81
Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5)Arhgef15 Kiaa0915Q5FWH61
Rho guanine nucleotide exchange factor 17Arhgef17 Kiaa0337Q80U351
Rho guanine nucleotide exchange factor 18Arhgef18 Kiaa0521Q6P9R41
Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF)Arhgef25 D10Ertd610e GeftQ9CWR01
Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1)Rnd1 Rho6Q8BLR71
Rho-related GTP-binding protein RhoBRhob ArhbP627461
Rho-related GTP-binding protein RhoC (Silica-induced gene 61 protein) (SIG-61)Rhoc ArhcQ621591
Rho-related GTP-binding protein RhoE (Rho family GTPase 3) (Rnd3)Rnd3 Arhe RhoeP615881
Rho-related GTP-binding protein RhoU (Rho GTPase-like protein ARHU) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)Rhou Arhu G28k Wrch1Q9EQT31
Rhomboid domain-containing protein 3Rhbdd3Q8BP971
Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1)Rnh1 RnhQ91VI71
Ribonuclease P protein subunit p20 (RNaseP protein p20) (EC 3.1.26.5)Pop7 Rpp20Q9DCH21
Ribonuclease P protein subunit p38 (Ribonuclease P/MRP 38 subunit (Human))Rpp38 mCG_17284A2AJG01
Ribonuclease P/MRP protein subunit POP5 (EC 3.1.26.5)Pop5Q9DB281
Ribonuclease ZC3H12A (EC 3.1.-.-) (MCP-induced protein 1) (Zinc finger CCCH domain-containing protein 12A)Zc3h12a Mcpip Mcpip1Q5D1E71
Ribosomal protein S6 kinase (EC 2.7.11.1)Rps6ka1Q505N61
Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase)Rps6kc1Q8BLK91
Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)Rrp1bQ91YK21
Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine-N1-)-methyltransferase NEP1) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1)Emg1 C2f Grcc2fO351301
Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14 homolog)Rrp7aQ9D1C91
Ribosome maturation protein SBDS (Protein 22A3) (Shwachman-Bodian-Diamond syndrome protein homolog)SbdsP701221
RIKEN cDNA 1700045I19Rnf138rt1 1700045I19Rik mCG_115698Q9D9M91
RING finger and transmembrane domain-containing protein 1Rnft1Q9DCN71
RING finger protein 145Rnf145Q5SWK71
RING finger protein 157Rnf157A2AAN91
RING finger protein 166Rnf166Q3U9F61
RING finger protein 17 (Mad member-interacting protein 2) (Mmip-2)Rnf17Q99MV71
RING finger protein 24Rnf24Q8BGI11
RING finger protein 37 (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)Ubox5 Rnf37 Ubce7ip5 Uip5Q925F41
RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1)RtcA Rpc1 Rtcd1Q9D7H31
RNA polymerase I-specific transcription initiation factor RRN3Rrn3B2RS911
RNA polymerase II-associated protein 3Rpap3 D15Ertd682eQ9D7061
RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)Rbm12Q8R4X31
RNA-binding protein 20 (RNA-binding motif protein 20)Rbm20Q3UQS81
RNA-binding protein 26 (Protein expressed in male leptotene and zygotene spermatocytes 393) (MLZ-393) (RNA-binding motif protein 26)Rbm26Q6NZN01
RNA-binding protein 27 (Peri-implantation stem cell protein 1) (RNA-binding motif protein 27)Rbm27 Kiaa1311Q5SFM81
RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33)Rbm33 Prr8Q9CXK91
RNA-binding protein 40 (RNA-binding motif protein 40) (RNA-binding region-containing protein 3)Rnpc3 Kiaa1839 Rbm40Q3UZ011
RNA-binding protein 47 (RNA-binding motif protein 47)Rbm47Q91WT81
RNA-binding protein with multiple splicing 2Rbpms2Q8VC521
Ropporin-1 (Rhophilin-associated 'oppo' protein) (Rhophilin-associated protein 1)Ropn1Q9ESG21
rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial large ribosomal RNA ribose methylase)Mrm1Q99J251
rRNA-processing protein FCF1 homologFcf1Q9CTH61
RUN and FYVE domain-containing protein 1 (Rab4-interacting protein)Rufy1 Rabip4Q8BIJ71
RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8)Rundc3a Rap2ip Rpip8O085761
S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)Bhmt2Q91WS41
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)Skp1 Skp1aQ9WTX51
S100P-binding proteinS100pbpQ9D5K41
SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1)Sac3d1 Shd1A6H6871
SAM and SH3 domain-containing protein 1Sash1P598081
SAP30-binding protein (Transcriptional regulator protein HCNGP)Sap30bp HcngpQ026141
Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein)Slmap Kiaa1601 SlapQ3URD31
SAYSvFN domain-containing protein 1Saysd1Q8K1901
Scaffold attachment factor B1 (SAF-B1)Safb Safb1D3YXK21
Scaffold attachment factor B2 (SAF-B2)Safb2Q80YR51
Scavenger receptor class A member 3Scara3Q8C8501
Scavenger receptor class A member 5Scara5Q8K2991
Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1-like 2)Scfd1 Stxbp1l2Q8BRF71
SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein)Sestd1Q80UK01
Secernin-2Scrn2Q8VCA81
Secreted frizzled-related protein 5 (sFRP-5)Sfrp5Q9WU661
Secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)Sslp1 Gm191Q3UN541
Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)]Pla2r1 Pla2g1brQ620281
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