| Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein) | Shpk Carkl | Q9D5J6 | 1 |
| Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Dvl1 Dvl | P51141 | 1 |
| Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog) | Bscl2 Gng3lg MNCb-2630 | Q9Z2E9 | 1 |
| Selection and upkeep of intraepithelial T-cells protein 2 (Skint 2 isoform d) | Skint2 OTTMUSG00000008540 | B2ZEZ5 | 1 |
| Selenium-binding protein 2 (56 kDa acetaminophen-binding protein) (AP56) | Selenbp2 Lpsb2 | Q63836 | 1 |
| Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) (mSelB) | Eefsec Selb | Q9JHW4 | 1 |
| Selenoprotein M (SelM) | Selm Sepm | Q8VHC3 | 1 |
| Selenoprotein P (SeP) (Plasma selenoprotein P) | Sepp1 Selp | P70274 | 1 |
| Selenoprotein T (SelT) | Selt | P62342 | 1 |
| Semaphorin-3A (Semaphorin III) (Sema III) (Semaphorin-D) (Sema D) | Sema3a Semad SemD | O08665 | 1 |
| Semaphorin-3E (Semaphorin-H) (Sema H) | Sema3e Semah Semh | P70275 | 1 |
| Semaphorin-3F (Semaphorin IV) (Sema IV) | Sema3f | O88632 | 1 |
| Semaphorin-3G | Sema3g | Q4LFA9 | 1 |
| Semaphorin-4A (Semaphorin-B) (Sema B) | Sema4a Semab SemB | Q62178 | 1 |
| Semaphorin-4G | Sema4g | Q9WUH7 | 1 |
| Semaphorin-6D | Sema6d Kiaa1479 | Q76KF0 | 1 |
| Sentan (Protein S100-A1-like) (S100 calcium-binding protein A1-like) | Sntn S100a1l | Q8C9X1 | 1 |
| Sentrin-specific protease 6 (EC 3.4.22.68) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Senp6 Kiaa0797 Susp1 | Q6P7W0 | 1 |
| Sentrin-specific protease 8 (EC 3.4.22.68) (Deneddylase-1) (NEDD8-specific protease 1) (Sentrin/SUMO-specific protease SENP8) | Senp8 Den1 Nedp1 | Q9D2Z4 | 1 |
| Septin-4 (Brain protein H5) (Peanut-like protein 2) | Sept4 Pnutl2 | P28661 | 1 |
| Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1) | Sept5 Pnutl1 | Q9Z2Q6 | 1 |
| Septin-6 | Sept6 Kiaa0128 | Q9R1T4 | 1 |
| Septin-8 | Sept8 Kiaa0202 | Q8CHH9 | 1 |
| Serine hydrolase-like protein (SHL) (EC 3.1.-.-) | Serhl | Q9EPB5 | 1 |
| Serine incorporator 1 (Axotomy-induced glyco/Golgi protein 2) (Membrane protein TMS-2) (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) | Serinc1 Aigp2 Tde1l Tde2 Tms2 | Q9QZI8 | 1 |
| Serine incorporator 2 (Tumor differentially expressed protein 2-like) | Serinc2 Tde2l | Q8K0E7 | 1 |
| Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3) | Sptlc3 Sptlc2l | Q8BG54 | 1 |
| Serine palmitoyltransferase small subunit A (Small subunit of serine palmitoyltransferase A) (ssSPTa) | Sptssa Ssspta | Q8R207 | 1 |
| Serine protease 23 (EC 3.4.21.-) | Prss23 | Q9D6X6 | 1 |
| Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease) | Htra3 Prsp Tasp | Q9D236 | 1 |
| Serine protease inhibitor A3C (Serpin A3C) (Kallikrein-binding protein) (KBP) | Serpina3c Klkbp | P29621 | 1 |
| Serine protease inhibitor kazal-like protein, minor form (SPINKL, minor form) [Cleaved into: Serine protease inhibitor kazal-like protein, major form (SPINKL, major form)] | Spinkl | Q8CEK3 | 1 |
| Serine-rich and transmembrane domain-containing protein 1 | Sertm1 | Q8CD78 | 1 |
| Serine/arginine-rich splicing factor 9 (Splicing factor, arginine/serine-rich 9) | Srsf9 Sfrs9 | Q9D0B0 | 1 |
| Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Stk10 Lok | O55098 | 1 |
| Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1) | Stk11ip Lip1 Lkb1ip | Q3TAA7 | 1 |
| Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Embryo-derived protein kinase) (Edpk) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase Krct) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) | Stk16 Edpk Krct Mpsk1 Pkl12 Tsf1 | O88697 | 1 |
| Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Stk25 Sok1 | Q9Z2W1 | 1 |
| Serine/threonine-protein kinase 35 (Serine/threonine-protein kinase 35 L1) (EC 2.7.11.1) | Stk35 Stk35l1 | Q80ZW0 | 1 |
| Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Stk38 Ndr1 | Q91VJ4 | 1 |
| Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine-protein kinase lyk4) | Stk40 Lyk4 | Q7TNL3 | 1 |
| Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Checkpoint kinase 2) | Chek2 Chk2 Rad53 | Q9Z265 | 1 |
| Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Prkd1 Pkcm Pkd Prkcm | Q62101 | 1 |
| Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Dclk1 Dcamkl1 Dclk | Q9JLM8 | 1 |
| Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Mastl Gw Gwl | Q8C0P0 | 1 |
| Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1) | Uhmk1 Kis Kist | P97343 | 1 |
| Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 3) (Lemur tyrosine kinase 3) | Lmtk3 Aatyk3 | Q5XJV6 | 1 |
| Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Cdc42bpb Kiaa1124 | Q7TT50 | 1 |
| Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | Pkn2 Prk2 Prkcl2 | Q8BWW9 | 1 |
| Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) | Nek1 | P51954 | 1 |
| Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) | Nek2 | O35942 | 1 |
| Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) | Nek4 Stk2 | Q9Z1J2 | 1 |
| Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) | Nek5 | Q7TSC3 | 1 |
| Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) | Plk2 Snk | P53351 | 1 |
| Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1) | Riok1 | Q922Q2 | 1 |
| Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) | Sgk1 Sgk | Q9WVC6 | 1 |
| Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (HRT-20) (Myocardial SNF1-like kinase) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Sik1 Msk Sik Snf1lk | Q60670 | 1 |
| Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) | Taok2 Kiaa0881 | Q6ZQ29 | 1 |
| Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Ulk3 | Q3U3Q1 | 1 |
| Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) | Wnk1 Hsn2 Prkwnk1 | P83741 | 1 |
| Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) | Wnk2 Kiaa1760 | Q3UH66 | 1 |
| Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) | Ppp2r2b | Q6ZWR4 | 1 |
| Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | Ppp2r2d D7Ertd753e Kiaa1541 | Q925E7 | 1 |
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform) | Ppp3ca Calna | P63328 | 1 |
| Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) | Ppp3cc Calnc | P48455 | 1 |
| Serine/threonine-protein phosphatase 4 regulatory subunit 4 | Ppp4r4 Kiaa1622 Pp4r4 | Q8C0Y0 | 1 |
| Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) | Ankrd44 | B2RXR6 | 1 |
| Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | Ppp6r1 Kiaa1115 Pp6r1 Saps1 | Q7TSI3 | 1 |
| Serine/threonine-protein phosphatase with EF-hands 2 (PPEF-2) (EC 3.1.3.16) | Ppef2 | O35385 | 1 |
| Serologically defined colon cancer antigen 3 homolog | Sdccag3 | A2AIW0 | 1 |
| Serpin B6 (Placental thrombin inhibitor) (Proteinase inhibitor 6) (PI-6) | Serpinb6 Serpinb6a Spi3 | Q60854 | 1 |
| SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator) | Sertad3 Rbt1 | Q9ERC3 | 1 |
| Serum amyloid A-3 protein | Saa3 | P04918 | 1 |
| Serum amyloid A-4 protein (Amyloid A-5 protein) | Saa4 Saa5 | P31532 | 1 |
| Serum amyloid P-component (SAP) | Apcs Ptx2 Sap | P12246 | 1 |
| Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | Srfbp1 | Q9CZ91 | 1 |
| Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase interacting protein A) (IPIP27A) | Fam109a | Q8BH49 | 1 |
| SH2 domain-containing protein 5 (Vascular SH2 domain-containing protein) | Sh2d5 | A2AM67 | 1 |
| SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1) | Sh2b1 Sh2bpsm1 | Q91ZM2 | 1 |
| SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Sh2b3 Lnk | O09039 | 1 |
| SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) | Shank2 Cortbp1 Kiaa1022 | Q80Z38 | 1 |
| SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Sh3pxd2b Fad49 Tks4 | A2AAY5 | 1 |
| SH3 domain-binding glutamic acid-rich-like protein 3 | Sh3bgrl3 | Q91VW3 | 1 |
| SH3 domain-binding protein 1 | Sh3bp1 | A2A5V3 | 1 |
| SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Sh3bp5 Sab | Q9Z131 | 1 |
| SH3 domain-containing protein 19 (Kryn) | Sh3d19 | Q91X43 | 1 |
| SHC SH2 domain-binding protein 1-like protein | Shcbp1l | Q3TTP0 | 1 |
| SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Shc1 Shc ShcA | P98083 | 1 |
| SHC-transforming protein 2 (Protein Sck) (Protein Sli) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) | Shc2 Sck ShcB | Q8BMC3 | 1 |
| Short stature homeobox protein 2 (Homeobox protein Og12X) (OG-12) (Paired family homeodomain protein Prx3) | Shox2 Og12x Prx3 | P70390 | 1 |
| Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase) | Acads | Q07417 | 1 |
| Sialic acid-binding Ig-like lectin 12 (Siglec-12) (Myeloid inhibitory siglec) (MIS) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (Sialic acid-binding Ig-like lectin E) (Siglec-E) (mSiglec-E) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) | Siglec12 Siglec5 Siglece Siglecl1 | Q91Y57 | 1 |
| Sialic acid-binding Ig-like lectin 5 (Siglec-5) (Sialic acid-binding Ig-like lectin F) (Siglec-F) (mSiglec-F) (CD antigen CD170) | Siglec5 Siglecf | Q920G3 | 1 |
| Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (Mouse skeletal muscle sialidase) (MSS) (Murine thymic sialidase) (MTS) (N-acetyl-alpha-neuraminidase 2) | Neu2 | Q9JMH3 | 1 |
| Sideroflexin-2 | Sfxn2 | Q925N2 | 1 |
| Sideroflexin-4 | Sfxn4 | Q925N1 | 1 |
| Sideroflexin-5 | Sfxn5 | Q925N0 | 1 |
| Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21) | Sec11c Sec11l3 Spc21 | Q9D8V7 | 1 |
| Signal recognition particle 54 kDa protein (SRP54) | Srp54 | P14576 | 1 |
| Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) | Srp68 | Q8BMA6 | 1 |