EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]EIF4A3 DDX48 KIAA0111P38919164
Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)KRT16 KRT16AP08779164
Prothrombin (EC (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]F2P00734164
Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3)SCAMP3 C1orf3 PROPIN1O14828164
Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (S31III125) (S31I125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta)TMED10 TMP21P49755164
Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1)VTA1 C6orf55 HSPC228 My012Q9NP79164
26S protease regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)PSMC4 MIP224 TBP7P43686163
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1)CHMP2A BC2 CHMP2O43633163
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)EIF2S1 EIF2AP05198163
Fibulin-1 (FIBL-1)FBLN1 PP213P23142163
Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B')HSPA6 HSP70B'P17066163
Peroxiredoxin-4 (EC (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372)PRDX4Q13162163
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)PTBP1 PTBP26599163
Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]PSAP GLBA SAP1P07602163
Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4)GDI1 GDIL OPHN2 RABGDIA XAP4P31150163
Tubulin beta-2A chain (Tubulin beta class IIa)TUBB2A TUBB2Q13885163
Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)TUBB4A TUBB4 TUBB5P04350163
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]SERPINA1 AAT PI PRO0684 PRO2209P01009162
Cytoplasmic aconitate hydratase (Aconitase) (EC (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)ACO1 IREB1P21399162
Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)HIST1H1C H1F2P16403162
Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)CD47 MER6Q08722162
Prostaglandin E synthase 3 (EC (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23)PTGES3 P23 TEBPQ15185162
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)RHOC ARH9 ARHCP08134162
Serine--tRNA ligase, cytoplasmic (EC (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)SARS SERSP49591162
Toll-interacting proteinTOLLIPQ9H0E2162
Tripeptidyl-peptidase 2 (TPP-2) (EC (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II)TPP2P29144162
Tyrosine-protein kinase Lyn (EC (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)LYN JTK8P07948162
ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]SLC25A5 ANT2P05141161
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)AP2A2 ADTAB CLAPA2 HIP9 HYPJ KIAA0899O94973161
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC (DNPK1) (p460)PRKDC HYRC HYRC1P78527161
Histone H3.2 (Histone H3/m) (Histone H3/o)HIST2H3A; HIST2H3C H3F2 H3FM; HIST2H3DQ71DI3161
Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)NCKAP1 HEM2 KIAA0587 NAP1Q9Y2A7161
Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)PAFAH1B1 LIS1 MDCR MDS PAFAHAP43034161
S-formylglutathione hydrolase (FGH) (EC (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC
60S ribosomal protein L22 (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) (Large ribosomal subunit protein eL22)RPL22P35268160
60S ribosomal protein L23 (60S ribosomal protein L17) (Large ribosomal subunit protein uL14)RPL23P62829160
Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005Q9Y262160
Histone H2A.V (H2A.F/Z)H2AFV H2AVQ71UI9160
Protein XRP2RP2O75695160
Syntaxin-4 (Renal carcinoma antigen NY-REN-31)STX4 STX4AQ12846160
60S acidic ribosomal protein P1 (Large ribosomal subunit protein P1)RPLP1 RRP1P05386159
Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)CHMP5 C9orf83 SNF7DC2 CGI-34 HSPC177 PNAS-114 PNAS-2Q9NZZ3159
Citrate synthase, mitochondrial (EC (Citrate (Si)-synthase)CSO75390159
Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta)LAMB1P07942159
Ras-related protein Rap-2cRAP2CQ9Y3L5159
Serpin H1 (47 kDa heat shock protein) (Arsenic-transactivated protein 3) (AsTP3) (Cell proliferation-inducing gene 14 protein) (Collagen-binding protein) (Colligin) (Rheumatoid arthritis-related antigen RA-A47)SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14P50454159
Sorbitol dehydrogenase (EC (L-iditol 2-dehydrogenase)SORDQ00796159
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)ARPC5 ARC16O15511158
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin]COL18A1P39060158
Deoxyribose-phosphate aldolase (DERA) (EC (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)DERA CGI-26Q9Y315158
Dipeptidyl peptidase 4 (EC (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]DPP4 ADCP2 CD26P27487158
Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP))EIF6 EIF3A ITGB4BP OK/SW-cl.27P56537158
Isoleucine--tRNA ligase, cytoplasmic (EC (Isoleucyl-tRNA synthetase) (IRS) (IleRS)IARSP41252158
Nidogen-1 (NID-1) (Entactin)NID1 NIDP14543158
Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)TSPAN14 TM4SF14Q8NG11158
40S ribosomal protein S23 (Small ribosomal subunit protein uS12)RPS23P62266157
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)IGF2R MPRIP11717157
Cofilin-2 (Cofilin, muscle isoform)CFL2Q9Y281157
Glycogen phosphorylase, liver form (EC
Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2)HSPA2P54652157
Ras-related protein Rab-11A (Rab-11) (YL8)RAB11A RAB11P62491157
Asparagine--tRNA ligase, cytoplasmic (EC (Asparaginyl-tRNA synthetase) (AsnRS)NARSO43776156
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC; Aspartate carbamoyltransferase (EC; Dihydroorotase (EC]CADP27708156
Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]C9P02748156
Elongation factor Tu, mitochondrial (EF-Tu) (P43)TUFMP49411156
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)EIF3C EIF3S8Q99613156
Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)HSPA1A HSP72 HSPA1 HSX70P0DMV8156
Heterogeneous nuclear ribonucleoprotein M (hnRNP M)HNRNPM HNRPM NAGR1P52272156
Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)S100A10 ANX2LG CAL1L CLP11P60903156
Protein-glutamine gamma-glutamyltransferase 2 (EC (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase-2) (TGase-2)TGM2P21980156
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC (EC
Ubiquitin thioesterase OTUB1 (EC (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)OTUB1 OTB1 OTU1 HSPC263Q96FW1156
Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)VDAC2P45880156
ADP-ribosylation factor 5ARF5P84085155
CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)CD82 KAI1 SAR2 ST6 TSPAN27P27701155
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)RPN1P04843155
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]FGAP02671155
Fibrinogen gamma chainFGG PRO2061P02679155
Flavin reductase (NADPH) (FR) (EC (Biliverdin reductase B) (BVR-B) (EC (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)BLVRB FLRP30043155
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]ITGA5 FNRAP08648155
Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP)ITIH2 IGHEP2P19823155
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)ICAM1P05362155
Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)ILF2 NF45 PRO3063Q12905155
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)LASP1 MLN50Q14847155
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC (Lysyl hydroxylase 1) (LH1)PLOD1 LLH PLODQ02809155
Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15)PDCD10 CCM3 TFAR15Q9BUL8155
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)SF3B3 KIAA0017 SAP130Q15393155
Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23)TPT1P13693155
60S ribosomal protein L27a (Large ribosomal subunit protein uL15)RPL27AP46776154
60S ribosomal protein L35a (Cell growth-inhibiting gene 33 protein) (Large ribosomal subunit protein eL33)RPL35A GIG33P18077154
Long-chain-fatty-acid--CoA ligase 4 (EC (Long-chain acyl-CoA synthetase 4) (LACS 4)ACSL4 ACS4 FACL4 LACS4O60488154
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)MAPK1 ERK2 PRKM1 PRKM2P28482154
Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)MVB12A CFBP FAM125AQ96EY5154
Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (SATT) (Solute carrier family 1 member 4)SLC1A4 ASCT1 SATTP43007154
60S ribosomal protein L31 (Large ribosomal subunit protein eL31)RPL31P62899153
Acetyl-CoA acetyltransferase, cytosolic (EC (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)ACAT2 ACTLQ9BWD1153
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)AP1B1 ADTB1 BAM22 CLAPB2Q10567153
Clathrin light chain A (Lca)CLTAP09496153
Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]F5P12259153
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